Gamma-delta T-cell phenotype is associated with significantly decreased survival in cutaneous T-cell lymphoma

Toro, Jorge R.; Liewehr, David J.; Pabby, Nina; Sorbara, Lynn; Raffeld, Mark; Steinberg, Seth M.; Jaffe, Elaine S.

doi:10.1182/blood-2002-05-1597

Cited by 282 publications

(269 citation statements)

References 35 publications

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“…Although hepatosplenic gamma delta T-cell lymphoma is the prototypic gamma delta T-cell neoplasm, mucocutaneous gamma delta T-cell lymphoma and gamma delta T-cell LGL leukemia have been described (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). With the exception of gamma delta T-cell LGL leukemia, these malignancies have a poor prognosis and require aggressive chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…The mucocutaneous gamma delta T cell lymphomas have varied clinical presentations, including subcutaneous panniculitis-like gamma delta T-cell lymphoma, mycosis fungoid-like cutaneous gamma delta T-cell lymphoma, nasal NK/T gamma delta T-cell lymphoma, and enteropathy type gamma delta T-cell lymphoma. Mucocutaneous gamma delta T-cell lymphomas differ from their alpha beta T-cell counterparts in that they are more aggressive neoplasms and survival is poor in comparison (6)(7)(8)(9)(10)(11)(12). Hemophagocytic syndrome and significant cytopenias can occur.…”

mentioning

confidence: 99%

“…Mucocutaneous gamma delta T-cell lymphomas also have been described and generally involve mucosa and skin (6)(7)(8)(9)(10)(11)(12). These anatomic locations are normal distribution sites for gamma delta T-cell lymphocytes and as such suggest the possible role of chronic antigen exposure in the pathogenesis of these tissue-restricted gamma delta T-cell lymphomas (6).…”

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confidence: 99%

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Flow cytometric immunophenotypic profiles of mature gamma delta T‐cell malignancies involving peripheral blood and bone marrow

Ahmad

Kingma

Jaffe

et al. 2005

Cytometry Part B Clinical

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Background: In this study we compared clinical findings with flow cytometric immunophenotypic results in a series of patients with aggressive and indolent gamma delta T-cell malignancies with peripheral blood and/or bone marrow involvement.Methods: Gamma delta T-cell malignancies were detected based on flow cytometric demonstration of an abnormal T-cell population staining positive with T-cell receptor gamma delta and confirmed by morphologic and clinical reviews. Clinical data were obtained through chart review and discussion with the patients' physicians.Results: Blood or bone marrow involvement was present in all patients. Hepatosplenic and cutaneous gamma delta T-cell lymphomas had an aggressive clinical course, whereas the gamma delta T-cell large granular lymphocyte (LGL) leukemias had an indolent course. Expressions of CD5, CD8, CD16, and CD57 differed in gamma delta T-cell LGL leukemia compared with hepatosplenic and cutaneous gamma delta T-cell lymphomas.Conclusions: Gamma delta T-cell malignancies have a poor prognosis with the exception of gamma delta T-cell LGL leukemia (indolent process). Because CD57 expression is specific for gamma delta T-cell LGL leukemias, expression of this antigen may be associated with a more indolent clinical course. Because cutaneous gamma delta T-cell lymphoma can present with peripheral blood involvement, flow cytometric evaluation of peripheral blood is important in staging these patients. Published 2005 Wiley-Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Flow cytometric immunophenotypic profiles of mature gamma delta T‐cell malignancies involving peripheral blood and bone marrow

Ahmad

Kingma

Jaffe

et al. 2005

Cytometry Part B Clinical

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“…[3][4][5] It is listed as a provisional entity in the World Health Organization (WHO)-European Organization for Research and Treatment of Cancer (EORTC) classification and represents a distinct lymphoma entity in the WHO classification (fourth edition, 2008). 4,6 Histologically, CGD-TCL presents with epidermotropic, dermal and/or subcutaneous infiltrates, or combinations of these patterns even in the same individual.…”

Section: Introductionmentioning

confidence: 99%

Two Cases of Primary Cutaneous Lymphoma With a γ/δ+ Phenotype and an Indolent Course

Kempf¹,

Kazakov

Scheidegger

et al. 2014

The American Journal of Dermatopathology

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Cutaneous [gamma]/[delta]+ T-cell lymphoma (CGD-TCL) is a rare but aggressive lymphoma associated with a poor prognosis in most patients. The clinicopathological spectrum is variable including predominantly epidermotropic infiltrates manifesting with patches and plaques or tumors with dermal and/or subcutaneous infiltrates. The diagnosis of CGD-TCL requires the demonstration of a [gamma]/[delta]+ phenotype by immunohistochemistry. We report 2 patients with epidermotropic cutaneous T-cell lymphomas displaying a [gamma]/[delta]+ phenotype, but exhibiting an indolent course. In one patient, the clinical presentation was similar to mycosis fungoides in patch and plaque stage, but recurrent blister formation within the lesions was observed accompanied by fever and arthralgias, whereas the second patient presented with 2 localized erosive plaques on the left temple and dense epidermotropic and dermal diffuse and folliculotropic infiltrates of atypical small-to-medium-sized lymphocytes. exhibiting an indolent course. In one patient, the clinical presentation was similar to mycosis fungoides in patch and plaque stage, but recurrent blister formation within the lesions was observed accompanied by fever and arthralgias, whereas the second patient presented with 2 localized erosive plaques on the left temple and dense epidermotropic and dermal diffuse and folliculotropic infiltrates of atypical small-tomedium-sized lymphocytes. These cases corroborate the view that expression of a g/d+ phenotype in cutaneous T-cell lymphomas per se does not portend a worse prognosis and that CGD-TCL may represent a clinically and prognostically heterogeneous group.

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“…Rare Subtypes Primary Cutaneous cd T-Cell Lymphoma.-These lymphoproliferative lesions with a cd phenotype are clinically aggressive 38 (median survival of~15 months) and consist of activated cytotoxic T cells with variable morphology. The variability in morphology is described within 3 major histologic patterns-primarily epidermotropic, dermal, and subcutaneous.…”

Section: Primary Cutaneous Peripheral T-cell Lymphomasmentioning

confidence: 99%

Best Practices in Diagnostic Immunohistochemistry: Workup of Cutaneous Lymphoid Lesions in the Diagnosis of Primary Cutaneous Lymphoma

Dewar¹,

Andea²,

Guitart³

et al. 2015

Archives of Pathology & Laboratory Medicine

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Context.-Primary cutaneous lymphoma is a common extranodal non-Hodgkin lymphoma. These lesions share common features with their nodal counterparts, but also have differences in morphology, unique clinical presentations, and immunohistochemical features.Objective. - Data Sources.-The WHO and EORTC classification publications and the relevant recent literature were used to compile appropriate and practical guidelines in this review.Conclusions.-The practice of dermatopathology and hematopathology varies widely. Thus, while this review provides an overview and guideline for the workup of lymphoid lesions of the skin, the practitioner should understand the importance of clinical correlation as well as appropriate utility of available resources (such as clonality testing) in arriving at a diagnosis in cutaneous lymphoid lesions.

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Gamma-delta T-cell phenotype is associated with significantly decreased survival in cutaneous T-cell lymphoma

Cited by 282 publications

References 35 publications

Flow cytometric immunophenotypic profiles of mature gamma delta T‐cell malignancies involving peripheral blood and bone marrow

Flow cytometric immunophenotypic profiles of mature gamma delta T‐cell malignancies involving peripheral blood and bone marrow

Two Cases of Primary Cutaneous Lymphoma With a γ/δ+ Phenotype and an Indolent Course

Best Practices in Diagnostic Immunohistochemistry: Workup of Cutaneous Lymphoid Lesions in the Diagnosis of Primary Cutaneous Lymphoma

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