Gamma Delta T Cell Subset V Gamma 2+ Expansion Associated with Longterm Infliximab Treatment in a Patient with Ankylosing Spondylitis

Gracey, Eric; Qaiyum, Zoya; Kuruvilla, John

doi:10.3899/jrheum.160425

Cited by 4 publications

(1 citation statement)

References 12 publications

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“…Interestingly, in contrast to IL23R + IL-17 + Vδ1 + T cells that are expanded in AS, Vδ2 + γδ T cells were found to be increased in patients with AS who were receiving infliximab (anti TNFα) therapy, relative to those not receiving this drug and HC. Most of these Vδ2 + T cells secreted IFNγ and not IL-17 [84].…”

Section: Ankylosing Spondylitis (As)mentioning

confidence: 94%

The Role of Gamma Delta T Cells in Autoimmune Rheumatic Diseases

Bank

2020

Cells

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Autoimmune rheumatic diseases (ARDs), affecting ~1–1.5% of all humans, are associated with considerable life long morbidity and early mortality. Early studies in the 1990s showed numerical changes of the recently discovered γδ T cells in the peripheral blood and in affected tissues of patients with a variety of ARDs, kindling interest in their role in the immuno-pathogenesis of these chronic inflammatory conditions. Indeed, later studies applied rapid developments in the understanding of γδ T cell biology, including antigens recognized by γδ T cells, their developmental programs, states of activation, and cytokine production profiles, to analyze their contribution to the pathological immune response in these disorders. Here we review the published studies addressing the role of γδ T in the major autoimmune rheumatic diseases, including rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, systemic lupus erythematosus and scleroderma, and animal models thereof. Due to their unique properties spanning adaptive and innate immune functions, the ever deeper understanding of this unique T cell population is shedding new light on the pathogenesis of, while potentially enabling new therapeutic approaches to, these diseases.

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Section: Ankylosing Spondylitis (As)mentioning

confidence: 94%

The Role of Gamma Delta T Cells in Autoimmune Rheumatic Diseases

Bank

2020

Cells

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Illuminating the impact of γδ T cells in man and mice in spondylarthritides

Meyer

2024

Eur J Immunol

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Spondylarthritides (SpA) are a group of autoinflammatory diseases affecting the spine, peripheral joints, and entheses, including axial spondyloarthritis (axSpA) and psoriatic arthritis. AxSpA has a multifactorial etiology that involves genetic predispositions, such as HLA‐B27 and IL‐23R. Although HLA‐B27 is strongly associated with axSpA, its role remains unclear. GWAS studies have demonstrated that genetic polymorphisms related to the IL‐23 pathway occur throughout the spectrum of SpA, including but not limited to axSpA and PsA. IL‐23 promotes the production of IL‐17, which drives inflammation and tissue damage. This pathway contributes not only to peripheral enthesitis but also to spinal inflammation. γδ T cells in axSpA express IL‐23R and RORγt, crucial for their activation, although specific pathogenic cells and factors remain elusive. Despite drug efficacy in PsA, IL‐23R inhibition is ineffective in axSpA. Murine models provide valuable insights into the intricate cellular and molecular interactions that contribute to the development and progression of SpA. Those models are useful tools to elucidate the dynamics of γδ T cell involvement, offering insights into disease mechanisms and potential therapeutic targets. This review aims to illuminate the complex interplay between IL‐23 and γδ T cells in SpA pathogenesis, emphasizing their roles in chronic inflammation, tissue damage, and disease heterogeneity.

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Infliximab

2017

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Gamma Delta T Cell Subset V Gamma 2+ Expansion Associated with Longterm Infliximab Treatment in a Patient with Ankylosing Spondylitis

Cited by 4 publications

References 12 publications

The Role of Gamma Delta T Cells in Autoimmune Rheumatic Diseases

The Role of Gamma Delta T Cells in Autoimmune Rheumatic Diseases

Illuminating the impact of γδ T cells in man and mice in spondylarthritides

Infliximab

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