Gamma radiation increases the risk of radiation-related root dental caries

Velo, Marilia Mattar de Amoêdo Campos; Farha, Ana Laura Herrera; Santos, Paulo Sérgio da Silva; Shiota, A.; Sansavino, Simone Zuquerato; Souza, Ana Tarsila Fonseca; Honório, Heitor Marques; Wang, Linda

doi:10.1016/j.oraloncology.2017.06.007

Cited by 16 publications

(6 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The mechanism of RRC includes two aspects: direct factors and indirect factors [ 25 ]. Concerning direct factors, radiation can lead to changes in the mechanical properties and chemical composition of teeth, directly destroying the enamel, dentin, and the dentinoenamel junction [ 8 , 26 , 27 ]. Although most people believe that direct factors play a significant role in forming radiation-related caries, direct damage to the teeth by radiation is still not negligible.…”

Section: Discussionmentioning

confidence: 99%

“…Most HNC patients have different symptoms and signs of periodontal diseases, such as gingival bleeding, periodontal pocket formation, gingival atrophy, loss of periodontal attachments, and tooth mobility during and after radiotherapy, significantly decreasing patients' quality of life [ 5 – 7 ]. High-dose radiation can directly damage dental structures and then develop into radiation-related caries (RRC) [ 8 , 9 ]. Furthermore, RRC will increase the risk of tooth loss, seriously influencing the patient's quality of life [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Dosimetric Comparison between Volumetric Modulated Arc Therapy (VMAT) and Intensity-Modulated Radiotherapy (IMRT) for Dental Structures of Head and Neck Cancer Patients

Zhou

Wang

2022

Journal of Healthcare Engineering

View full text Add to dashboard Cite

Background. This retrospective study aimed to evaluate the radiation dose delivered to dental structures in intensity-modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) without dental dose constraints, compare the dosimetry differences of dental structures between the two radiation techniques, and determine whether dental structures should be one of the organs at risk for IMRT and VMAT plans according to the dosimetric analysis. Materials and Methods. A total of 138 head and neck cancer patients (nasopharyngeal, oral cavity, pharyngeal, hypopharynx, and larynx), who underwent IMRT (69 patients) or VMAT (69 patients) from March 2016 to March 2021 in our hospital, were included to assess the dosimetry difference between two radiotherapy techniques for dental structures. Results. The radiation dose delivered by IMRT and the mean maximum doses delivered by VMAT to the maxillary teeth of nasopharyngeal cancer patients were significantly higher than the dose received by the mandibular teeth. In contrast, the mandibular teeth of oral cavity cancer, oropharynx cancer, and laryngeal cancer received higher radiation doses than maxillary teeth. Except for mandibular teeth of oral cancer patients, the molars received significantly high-dose radiation than premolars and/or incisors in both radiotherapy techniques. No significant difference was observed between IMRT and VMAT in the dosimetric comparison of dental structures, except that oral cavity cancer patients treated with VMAT received a significantly higher mean average dose than those treated with IMRT. When PTV included level Ib, the radiation doses of the mandibular teeth delivered by both radiotherapy techniques were significantly higher than that in PTV when level Ib was excluded. Conclusion. Without dental dose constraints, no major difference was observed between IMRT and VMAT plans in tooth dose distribution. We suggest that dental structures should be delineated as part of the organ at risk (OAR) when IMRT and VMAT are planned. Meanwhile, attention should be paid to dental structures that might have a high-dose area according to the specific tumor location.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dosimetric Comparison between Volumetric Modulated Arc Therapy (VMAT) and Intensity-Modulated Radiotherapy (IMRT) for Dental Structures of Head and Neck Cancer Patients

Zhou

Wang

2022

Journal of Healthcare Engineering

View full text Add to dashboard Cite

show abstract

“…( 20 ) The dentin can also suffer changes, such as obturation of the dentinal tubules and dehydration, increasing the possibility of caries in this region. ( 21 ) This study evaluated the prevalence of dental caries according to the DMFT index, which does not allow the record of the specific region of dental caries, for example, the cervical area of a tooth. Consequently, despite this area being the most affected, as per the literature, it was not possible to determine which area of the tooth was affected by the caries.…”

Section: Discussionmentioning

confidence: 99%

Case-control study of oral disease indexes in individuals with head and neck cancer after antineoplastic therapy

Quispe

Cremonesi

Gonçalves

et al. 2018

Einstein (São Paulo)

View full text Add to dashboard Cite

Objective To evaluate the oral health of patients with head and neck cancer after antineoplastic treatment, and to compare them with patients with no history of cancer.Methods A total of 75 patients, divided into Study Group, composed of individuals after antineoplastic treatment (n=30), and Control Group, with individuals with no history of cancer (n=45), aged 37 to 79 years. The oral health status was evaluated through the index of decayed, missing or filled permanent teeth (DMFT), community periodontal index and evaluation of the use and need of prosthesis. All of these items were evaluated according to the criteria recommended by the World Health Organization. The statistical analysis was descriptive and used the Pearson’s χ2 test.Results The community periodontal index was higher in the Study Group when compared to the Control Group (p<0.0001). The need for an upper (p<0.001) and lower (p<0.0001) prostheses was higher in the Study Group. Also, the use of upper prosthesis was higher in the Study Group (p<0.002). The missing or filled permanent teeth index between the two groups (p>0.0506) and the use of lower prosthesis (p>0.214) did not present a relevant statistical difference.Conclusion Periodontal disease and edentulism are the most significant changes in individuals who received antineoplastic therapy for head and neck cancer as well as greater need for oral rehabilitation.

show abstract

“…Gamma (γ) radiation was extensively used in both in vitro and in vivo studies to identify extracts/compounds having radioprotective activity and to further study their mechanistic pathways to repair the cell damage. Patients receiving gamma radiation as part of their radiotherapy are at higher risk such as root dental caries (Campos Velo et al 2017 ). Breast cancer imaging such as breast-specific gamma imaging (BSGI) was also reported to increase the risk of breast cancer (Hendrick 2010 ).…”

Section: In Vitro and In Vivo Studies Based On Radiation-induced Damagementioning

confidence: 99%

Advances on marine-derived natural radioprotection compounds: historic development and future perspective

Abraham

Alghazwi

Liang

et al. 2021

Mar Life Sci Technol

View full text Add to dashboard Cite

Natural extracts and compounds from marine resources have gained intensive scientific and industry attention for radioprotective activities in the past ten years. However, the marine-derived radioprotectants have been studied against UV-rays, gamma (γ)-rays and X-rays for more than 30 years. This review aims to identify key marine-derived extracts/compounds and their modes of action studied for radioprotective activities from 1986 to 2019. A comprehensive survey was conducted to establish the trend in terms of the publications each year and the countries of origin. A total of 40 extracts and 34 natural compounds showing radioprotective activities against UV-rays, gamma (γ)-rays and X-rays were identified from a range of marine plants and animals. These extracts and compounds are broadly categorized into polysaccharides, phlorotannins, carotenoids and mycosporine-like amino acids (MAAs). Macroalgae and microalgae were found to be the dominant sources of polysaccharides, phlorotannins and carotenoids. MAAs were mainly identified in algae, sponges, sea cucumber and corals that showed significant UV-absorbing activities. A number of radioprotective mechanisms were shown by these compounds, predominantly free radicals scavenging, inhibition of apoptosis, UV-ray absorption and DNA damage-repair signaling pathways. While these bio-discoveries warrant further investigation and development of radioprotective therapeutics, however, the lack of clinical studies is a major obstacle to be tackled in the future.

show abstract

Gamma radiation increases the risk of radiation-related root dental caries

Cited by 16 publications

References 11 publications

Dosimetric Comparison between Volumetric Modulated Arc Therapy (VMAT) and Intensity-Modulated Radiotherapy (IMRT) for Dental Structures of Head and Neck Cancer Patients

Dosimetric Comparison between Volumetric Modulated Arc Therapy (VMAT) and Intensity-Modulated Radiotherapy (IMRT) for Dental Structures of Head and Neck Cancer Patients

Case-control study of oral disease indexes in individuals with head and neck cancer after antineoplastic therapy

Advances on marine-derived natural radioprotection compounds: historic development and future perspective

Contact Info

Product

Resources

About