2010
DOI: 10.1093/carcin/bgq141
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Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk

Abstract: Background: DNA strand breaks pose the greatest threat to genomic stability. Genetically determined mutagen sensitivity predisposes individuals to a variety of cancers, including glioma. However, polymorphisms in DNA strand break repair genes that may determine mutagen sensitivity are not well studied in cancer risk, especially in gliomas. Methods: We correlated genotype data for tag single-nucleotide polymorphisms (tSNPs) of DNA strand break repair genes with a gamma-radiation-induced mutagen sensitivity phen… Show more

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Cited by 11 publications
(12 citation statements)
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“…Of note, a strong correlation between polymorphysms/haplotypes of the RAD51L1 gene and a g-radiation sensitive phenotype in glioma patients has recently been identified, supporting the notion that inability to repair DSBs by HR increases sensitivity to g-radiation and promotes brain tumorigenesis in humans (Liu et al, 2010).…”
Section: Discussionmentioning
confidence: 67%
“…Of note, a strong correlation between polymorphysms/haplotypes of the RAD51L1 gene and a g-radiation sensitive phenotype in glioma patients has recently been identified, supporting the notion that inability to repair DSBs by HR increases sensitivity to g-radiation and promotes brain tumorigenesis in humans (Liu et al, 2010).…”
Section: Discussionmentioning
confidence: 67%
“…The discrepancy may be attributed to differences in sample size, ethnic populations, and study design, as well as the different roles of HRR genes in diverse cancers. However, the risk implication of RAD51B variants seems to be an exception, which has been robustly replicated in different studies on breast cancer , nasopharyngeal carcinoma , glioma , and cutaneous melanoma , suggesting the significant role of RAD51B variants in cancer risk.…”
Section: Discussionmentioning
confidence: 95%
“…Recent evidence suggests that several single nucleotide polymorphisms (SNPs) in the DSB repair pathway genes may be prognostic biomarkers for GBM survival and modulate gamma-radiation-induced mutagen sensitivity in glioma patients [12,13]. Genetic variants in DSB repair pathway genes have been extensively studied in multiple cancers.…”
Section: Introductionmentioning
confidence: 99%