Gamma-Ray-Induced Permeability Changes in Relation to Early Mortality in the Chick

Early Radiation Lethality: Enzyme Release and the Protective Action of Soybean Trypsin Inhibitor

“…Early decreases in plasma volume and protein concentration indicate increased vascular permeability, ( 1,2 ) and terminal events include hemoconcentration, capillary engorgement and stasis, and degenerative changes in the endothelium (3 ) . Early decreases in plasma volume and protein concentration indicate increased vascular permeability, ( 1,2 ) and terminal events include hemoconcentration, capillary engorgement and stasis, and degenerative changes in the endothelium (3 ) .…”

Acute -lrradiation-lnduced Mortality in Chickens I. Mechanism of Resistance Afforded by Pretreatment with Cyclophosphamide or Sublethal Irradiation

“…This syndrome appears r a p idly after irradiation and includes an increase in vascular permeability, plasma leakage, hemoconcentration, and degenerative changes in the endothelium (2). This drastic increase in vascular permeability may represent an exaggerated form of similar permeability changes seen after irradiation in rabbits, rodents, and dogs (3,4).…”

“…It was considered of interest to deter-mine whether the vascular collapse and loss of circulating plasma described by others (1,2) was associated with enhanced vascular permeability. In view of the rapidity with which hemoconcentration and plasma volume changes occur (1,2), the birds were injected with Evans blue within 2 to 3 hr after irradiation. Enhanced permeability a Injected intravenously 1 to 4 days after the last cyclophosphamide injection and 1 to 2 days prior to irradiation.…”