Gangliogliomas

Abstract

Ganglioglioma is an uncommon central nervous system tumor. The role of adjuvant postoperative radiation therapy is undefined. The authors retrospectively reviewed the clinicopathologic features and results of therapy for 34 patients with ganglioglioma treated at the University of California at Los Angeles. There were 18 women and 16 men. Median age was 18 years. Twenty-five tumors were low grade. Twenty-one patients underwent gross total resection. Three patients received adjuvant radiotherapy. The 4-year actuarial progression free and overall survival rates were 67% and 75%, respectively. The median time to progression was 14 months and all relapses were local. Factors significantly influencing progression-free or overall survival according to univariate analysis included degree of resection and tumor grade. Survival and relapse were not significantly influenced by any factor according to multivariate analysis. The progression-free survivals after gross total resection of low- and high-grade tumors were 78% and 75%, respectively. Respective rates after subtotal resection were 63% and 25%. Review of the literature demonstrates no role for radiotherapy after total resection of ganglioglioma or after partial removal of low-grade tumor. Radiation therapy appears to reduce the relapse rate after partial removal of high-grade lesions. A dose in excess of 5,000 cGy is necessary for ganglioglioma.

Gliomas in the Sellar Turcica Region: A Retrospective Study Including Adult Cases and Comparison with Craniopharyngioma

“…Ganglioglioma is a less common glioma that belongs to mixed neuronal-glial tumors. It accounts for 1.14% of the general series in the present study and 0.4-4.3% in other reports, and it predominately affects young patients [21]. Pituicytoma is a new entity in the 2007 classification with approximately 50 cases reported worldwide.…”

MRI-characteristics of epileptogenic supratentorial brain tumors in children

“…В некоторых случаях описывается наличие в структуре опухоли микрокист [6]. Ряд авторов отмечают, что кон-трастное усиление может встречаться в 50% случаев, как и наличие петрификатов [6,17]. Излюбленным местом ло-кализации ГГ являются височные и теменные доли мозга [3,6,8,17].…”

“…Ряд авторов отмечают, что кон-трастное усиление может встречаться в 50% случаев, как и наличие петрификатов [6,17]. Излюбленным местом ло-кализации ГГ являются височные и теменные доли мозга [3,6,8,17]. Довольно часто ГГ располагается в конвекси-тальных отделах и вовлекает в процесс корковую пластин-Рис.…”

“…Преобладание кистозного компонента, из-за ко-торого можно не увидеть мелкого узла и отсутствие роста, нивелирует динамическую оценку и затрудняет диффе-ренциальную диагностику [3]. Учитывая, что ГГ наряду с ДНЭО является одной из наиболее частых причин сим-птоматической эпилепсии при наличии неуклонного про-грессирования приступов, рядом авторов рекомендуется исключать прежде всего присутствие ГГ коркового распо-ложения [3,[16][17][18].…”

Pediatric Primary Anaplastic Ganglioglioma: A Case Report and Review of the Literature

“…Since the malignant degeneration has been described both in previously irradiated [14,17] and nonirradiated patients [11,18,19,20], the evidence for a relationship between RT and anaplastic transformation seems to be weak [21]. …”