Ganglion cell layer segmentation and the two-flash multifocal electroretinogram improve structure function analysis in early glaucoma

Ledolter, Anna A.; Monhart, Matthias; Schötzau, Andreas; Palmowski-Wolfe, Anja

doi:10.1007/s00417-017-3722-x

Cited by 6 publications

(8 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to a standard examination, Brandao et al applied visual field analysis, GCL-IPL complex measurement, and the 2F-mfERG test to the participants in their study and evaluated the relationship of these findings with each other. The authors determined that in patients with early-stage glaucoma, the 2F-mfERG and GCL-IPL tests were the diagnostic tools with the highest probability of detecting glaucomatous dysfunction, and combining functional and structural tests is valuable in terms of early diagnosis [11]. Similarly, Talamini et al [27] showed that although the use of OCT segmentation analysis in glaucoma was beneficial in increasing OCT sensitivity, there were still many patients with normally appearing retinas, but mfERG was able to document retinal dysfunction in these patients and combining these two tests had diagnostic value.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Spectral-Domain Optical Coherence Tomography and Multifocal Electroretinography Results in the Long-Term Follow-Up of Glaucoma Patients

Çetinkaya

İnan

Yiğit³

et al. 2020

View full text Add to dashboard Cite

Objective: To investigate the changes in macular retinal layers and panretinal neuroretinal functions in the long-term follow-up of patients with primary open-angle glaucoma. Materials and Methods: Forty-one patients diagnosed with primary open-angle glaucoma were followed up for 12 months. According to their mean deviation (MD) values), the patients were put into two groups as Group 1 with early stage glaucoma (MD≥-6) and Group 2 with middle-advanced stage glaucoma (MD<-6). Optical coherence tomography (OCT) and multifocal electroretinography (mfERG) were performed at the baseline and at the sixth- and 12th-month evaluations. The OCT, retinal layer and mfERG findings were compared between the two groups. Results: There was no statistically significant difference between the groups in terms of gender and age In Group 2, the mean baseline macula Retina Nerve Fiber Layer, Ganglion Cell Layer and Inner Pleksiform Layer measurements were lower in each quadrant compared to Group 1. Concerning progression in OCT measurements, there was no significant difference between the two groups. However, it was noteworthy that in Group 2, there was a decrease especially in the first and second ring amplitudes of the P1 and N2 waves and prolongation of the implicit time. At the 12-month evaluation, there was prolongation of the implicit time of the N1 wave and a decrease in the P1 wave amplitude in Group 1. Conclusion: Retinal layers are affected in patients with intermediate and advanced stage glaucoma. In the follow-up of early stage glaucoma patients, mfERG measurements can show damage that may occur.

show abstract

Section: Resultsmentioning

confidence: 99%

“…Studies have shown that in glaucoma patients, the inner plexiform layer (IPL), especially the macular ganglion cell layer (GCL) is affected [7,8,9,10]. Strong correlations have been demonstrated between the GCL + IPL complex and multifocal electroretinography (mfERG) measurements [4,11].…”

Section: Introductionmentioning

confidence: 99%

Spectral-Domain Optical Coherence Tomography and Multifocal Electroretinography Results in the Long-Term Follow-Up of Glaucoma Patients

Çetinkaya

İnan

Yiğit³

et al. 2020

View full text Add to dashboard Cite

show abstract

“…However, bipolar cells in the inner retinal layer also contribute to the mf-ERG wave components. Many studies on this issue report that mf-ERG can provide valuable information concerning progression, especially in the early stages of glaucoma (29,30). These studies suggest that during the early stages of glaucoma, electrical activity may be affected before anatomical and morphological changes in the macula.…”

Section: Discussionmentioning

confidence: 99%

Choroidal Thickness and Its Correlations with Ocular Parameters in Primary Open-Angle Glaucoma

Kutluksaman¹

2019

Beyoglu Eye J

View full text Add to dashboard Cite

To evaluate the relationships between macular choroidal thickness (mCT) and ocular parameters, such as optic nerve head (ONH) and multifocal electroretinogram (mf-ERG) parameters, in cases with primary open-angle glaucoma (POAG). Methods: This controlled and prospective clinical trial included 49 patients with POAG diagnosed for the fırst time and 47 healthy participants. Macular CTs, ONH and mf-ERG parameters were measured, and the examination findings were recorded at baseline and follow-ups. Results: In the POAG group, the mean mCT was 254.92±37.65 μm at baseline, and it was 235.6±38.48 μm at 3-month and was 237.55±37.27 μm at 6-month. In the glaucoma group, there was a significant decrease in the first three months despite the treatment, but no significant change was observed in the next three months. In the healthy group, the mean mCTs were 287.78±26.77 μm, 285.48±25.58 μm and 285.02±27.44 μm at baseline, at 3-month and at 6-month, respectively. No significant change was observed in the control group throughout the process. However, the mean mCT values in the glaucoma group were significantly thinner in all controls compared to the healthy group (p<0.05). Furthermore, significant correlations were found between CT and some ONH, as well as mf-ERG parameters. Conclusion: The choroid can play an important role in the pathogenesis of glaucoma. Significant correlations in parameters support this relationship. We have observed that the glaucomatous effect initiated first in the inferior quadrant of ONH.

show abstract

“…We calculated the N/T-namely, the ratio of the mfERG P1 amplitudes of the rst slice of the second-order kernel (Figure 2b)-in the nasal hemisphere of the VF (i.e., temporal hemisphere of the retina) and compared with that in the temporal hemisphere of the VF (i.e., nasal hemisphere of the retina) in the central 5°. We also calculated the correlations between the thresholds obtained from the corresponding VF area, OCT parameters, and the N/T [18,19].…”

Section: Nasal To Temporal Amplitude Ratio Analyses Of Mferg Scansmentioning

confidence: 99%

“…To compare the mfPhNR/B with the corresponding VF ndings, we measured the thresholds with the HFA 30-2 and averaged for the same sectors according to the distance from the macula within the central 20° ( Figure 4). We also calculated the correlations between the thresholds of the corresponding VF area, the mfPhNR/B, and OCT parameters [18,19].…”

Section: Mfphnr/b Analysesmentioning

confidence: 99%

Relationship between structural and functional changes in glaucomatous eyes: A multifocal electroretinogram study

Tanaka

Ishida

Ozawa

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: The nasal to temporal amplitudes ratio (N/T) of multifocal electroretinography (mfERG) scans measured within 5° of the macula can be used to detect glaucomatous change. The photopic negative response (PhNR) of mfERG elicited by a circular stimulus centered on the fovea was significantly reduced in eyes with glaucoma. The PhNR to B-wave ratio (PhNR/B) is the optimal measure of the PhNR. However, clinical superiority for evaluating glaucoma patients has not been determined between N/T and PhNR/B yet. Methods: For morphological assessments, ganglion cell complex (GCC) in six regions and the average were measured by optical coherence tomography (OCT). For functional assessment, Humphrey visual fields (VF) with mean sensitivities (MT) and mfERG scans with parameters of N/T and the multifocal photopic negative response to B-wave ratio (mfPhNR/B) were measured. Sixty-nine eyes of forty-four glaucoma patients were included and correlations between mfERG parameters and OCT or VF parameters were evaluated. Results: The mean age of patients was 59.4 years. The mean deviation for all eyes obtained with the VF 30-2 and VF 10-2 was -7.00 and -6.31 dB, respectively. Significant correlations between GCC thickness or VF parameter and the N/T were found, especially in the inferior and inforotemporal retinal areas corresponding to superior and superonasal VF sectors (GCC vs N/T; coefficient = -7.916 and -7.857, and MT vs N/T ; coefficient = -4.302 and -4.437, in the inferior and inforotemporal retinal areas, respectively, all p values < 0.05). However, similar associations were not obtained between mfPhNR/B and OCT or VF parameters. The mfPhNR/B only in the inferotemporal sector was significantly correlated with the average thickness of GCC (coefficient = 4.823, P = 0.012). Conclusions: The N/T is better parameter than PhNR/B for the assessment of glaucomatous eyes in the current study’s measurement conditions. A future study modifying the stimuli and amplitudes to obtain the spatial correspondence to OCT and VF measurement will be required to evaluate the value of mfERG.

show abstract

Ganglion cell layer segmentation and the two-flash multifocal electroretinogram improve structure function analysis in early glaucoma

Cited by 6 publications

References 53 publications

Spectral-Domain Optical Coherence Tomography and Multifocal Electroretinography Results in the Long-Term Follow-Up of Glaucoma Patients

Spectral-Domain Optical Coherence Tomography and Multifocal Electroretinography Results in the Long-Term Follow-Up of Glaucoma Patients

Choroidal Thickness and Its Correlations with Ocular Parameters in Primary Open-Angle Glaucoma

Relationship between structural and functional changes in glaucomatous eyes: A multifocal electroretinogram study

Contact Info

Product

Resources

About