Ganoderic Acid and Lucidenic Acid (Triterpenoid)

Hsu, Chin‐Lin; Yen, Gow‐Chin

doi:10.1016/b978-0-12-802215-3.00003-3

Cited by 32 publications

(19 citation statements)

References 100 publications

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“…Ganoderma lucidum ( G. lucidum ), a well-known Chinese traditional medicine [ 11 ], has been used as a dietary supplement or drug to increase energy, improve immunity, and promote health and longevity for over 2000 years in Asian countries. Numerous bioactive constituents of G. lucidum , including terpenes, proteins, polysaccharides, amino acids, flavonoids, alkaloids, steroids, mannitol, and other compounds, have been revealed [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Ganoderic acid hinders renal fibrosis via suppressing the TGF-β/Smad and MAPK signaling pathways

Geng

et al. 2019

Acta Pharmacol Sin

131

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Renal fibrosis is considered as the pathway of almost all kinds of chronic kidney diseases (CKD) to the end stage of renal diseases (ESRD). Ganoderic acid (GA) is a group of lanostane triterpenes isolated from Ganoderma lucidum , which has shown a variety of pharmacological activities. In this study we investigated whether GA exerted antirenal fibrosis effect in a unilateral ureteral obstruction (UUO) mouse model. After UUO surgery, the mice were treated with GA (3.125, 12.5, and 50 mg· kg −1 ·d − 1 , ip) for 7 or 14 days. Then the mice were sacrificed for collecting blood and kidneys. We showed that GA treatment dose-dependently attenuated UUO-induced tubular injury and renal fibrosis; GA (50 mg· kg −1 ·d − 1 ) significantly ameliorated renal disfunction during fibrosis progression. We further revealed that GA treatment inhibited the extracellular matrix (ECM) deposition in the kidney by suppressing the expression of fibronectin, mainly through hindering the over activation of TGF-β/Smad signaling. On the other hand, GA treatment significantly decreased the expression of mesenchymal cell markers alpha-smooth muscle actin (α-SMA) and vimentin, and upregulated E-cadherin expression in the kidney, suggesting the suppression of tubular epithelial-mesenchymal transition (EMT) partially via inhibiting both TGF-β/Smad and MAPK (ERK, JNK, p38) signaling pathways. The inhibitory effects of GA on TGF-β/Smad and MAPK signaling pathways were confirmed in TGF-β1-stimulated HK-2 cell model. GA-A, a GA monomer, was identified as a potent inhibitor on renal fibrosis in vitro. These data demonstrate that GA or GA-A might be developed as a potential therapeutic agent in the treatment of renal fibrosis.

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Section: Introductionmentioning

confidence: 99%

Ganoderic acid hinders renal fibrosis via suppressing the TGF-β/Smad and MAPK signaling pathways

Geng

et al. 2019

Acta Pharmacol Sin

131

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Section: Ganoderic Acidsmentioning

confidence: 99%

“…Ganoderic acids are the bioactive Triterpenes produced by Ganoderma species [37]. Some of the reported Ganodermic acids are A, AM1, B, β, C1, C2,C6, D, Df, DM, E, F, G, H,J,K, Mc, Me, Nf, Mk, N, P, R, S, Sz,T, TR,TQ, X, and Y [37]. Studies on ganoderic acids revealed that they exhibit various biological activities such as anti-thrombosis [38], anti-tumor [39], and neuroprotective activities [40].…”

Section: Ganoderic Acidsmentioning

confidence: 99%

Antiviral Potential of Mushrooms in the Light of their Biological Active Compounds

2019

ARC Journal of Pharmaceutical Sciences

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Life-threaten diseases, especially those caused by viruses, require searching and investigation in order to find potent compounds and drugs. Mushrooms are promising sources of compounds showing bioactive potency whenever tested. This review highlights extracts and compounds originated from mushrooms fruiting bodies and or mycelia. Further studies are encouraged to discover novel potent antiviral compounds/ extracts or evaluate already known compounds extracted from those edible medicinal mushrooms.

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“…GAs. The main active ingredients of G. lucidum exhibit various biological activities, such as anti-oxidation, anti-virus and anti-tumor activities [3]. The content of GAs is also an important quality index of G. lucidum [4,5].…”

Section: Introductionmentioning

confidence: 99%

Integrated Proteomics and Metabolomics Analysis Provides Insights into Ganoderic Acid Biosynthesis in Response to Methyl Jasmonate in Ganoderma Lucidum

Jiang

Liu

et al. 2019

IJMS

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Ganoderma lucidum is widely recognized as a medicinal basidiomycete. It was previously reported that the plant hormone methyl jasmonate (MeJA) could induce the biosynthesis of ganoderic acids (GAs), which are the main active ingredients of G. lucidum. However, the regulatory mechanism is still unclear. In this study, integrated proteomics and metabolomics were employed on G. lucidum to globally identify differences in proteins and metabolites under MeJA treatment for 15 min (M15) and 24 h (M24). Our study successfully identified 209 differential abundance proteins (DAPs) in M15 and 202 DAPs in M24. We also identified 154 metabolites by GC–MS and 70 metabolites by LC–MS in M24 that are involved in several metabolic pathways. With an in-depth analysis, we found some DAPs and metabolites that are involved in the oxidoreduction process, secondary metabolism, energy metabolism, transcriptional and translational regulation, and protein synthesis. In particular, our results reveal that MeJA treatment leads to metabolic rearrangement that inhibited the normal glucose metabolism, energy supply, and protein synthesis of cells but promoted secondary metabolites, including GAs. In conclusion, our proteomics and metabolomics data further confirm the promoting effect of MeJA on the biosynthesis of GAs in G. lucidum and will provide a valuable resource for further investigation of the molecular mechanisms of MeJA signal response and GA biosynthesis in G. lucidum and other related species.

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Ganoderic Acid and Lucidenic Acid (Triterpenoid)

Cited by 32 publications

References 100 publications

Ganoderic acid hinders renal fibrosis via suppressing the TGF-β/Smad and MAPK signaling pathways

Ganoderic acid hinders renal fibrosis via suppressing the TGF-β/Smad and MAPK signaling pathways

Antiviral Potential of Mushrooms in the Light of their Biological Active Compounds

Integrated Proteomics and Metabolomics Analysis Provides Insights into Ganoderic Acid Biosynthesis in Response to Methyl Jasmonate in Ganoderma Lucidum

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