Ganoderma atrum polysaccharide attenuates oxidative stress induced by d-galactose in mouse brain

Li, Wenjuan; Nie, Shaoping; Xie, Mingyong; Yu, Qiang; Chen, Yi; He, Ming

doi:10.1016/j.lfs.2011.02.010

Cited by 40 publications

(33 citation statements)

References 43 publications

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“…In addition, PSG-1 has been shown to possess anti-aging and anticancer activities. Our results showed that it suppressed the growth of Sarcoma-180 tumour cells possibly by boosting the host immune system (Li et al, 2011;Zhang et al, 2013). Furthermore, it considerably stimulated RAW264.7 cells and resulted in the secretion of cytokines and chemokines (Yu et al, 2013).…”

Section: Introductionmentioning

confidence: 58%

Sulfated modification of the polysaccharides from Ganoderma atrum and their antioxidant and immunomodulating activities

et al. 2015

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Section: Introductionmentioning

confidence: 58%

Sulfated modification of the polysaccharides from Ganoderma atrum and their antioxidant and immunomodulating activities

et al. 2015

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“…(Yu-Hong et al, 2002;Zhang et al, 2003;Sun et al, 2004;Zhao et al, 2004;Chen et al, 2008;Jia et al, 2009;Li et al, 2009;Li et al, 2010;Li et al, 2011;Li et al, 2012a).…”

Section: Ganoderma Glycopeptidesunclassified

Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities

et al. 2015

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This review aims to contribute to the growing knowledge on bioactive (antioxidant, antitumor and antimicrobial) properties of polysaccharides, glycoproteins and polysaccharidic extracts obtained from Ganoderma species. The chemical features were analyzed and related to correspondent bioactivities. ____________________________________________________________________ 2 Research highlightsChemical features of Ganoderma bioactive polysaccharides were discussed.Methods for extraction, isolation and identification were evaluated.Bioactivity of polysaccharidic extracts and purified compounds were discussed.Integration of data allowed deduction of structure-activity relationships.

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“…Although some researchers have challenged the D-gal-induced aging model, 2,3 some other researchers indicate that D-gal-treated animals showed some hallmarks of aging, such as a shortened lifespan, 4 cognitive dysfunction, 5 presbycusis, 6 increased oxidative stress, 4,7 decreased antioxidant enzyme activity, 8 diminished immune responses, 9 increased advanced glycation endproducts, 10 accumulation of mitochondrial DNA mutations, 11 and mitochondrial dysfunction. 5,12 Mitochondria are not only the major sites of intracellular reactive oxygen species (ROS) production, but also targets of ROS.…”

Section: Introduction Dmentioning

confidence: 99%

D-Galactose Induces a Mitochondrial Complex I Deficiency in Mouse Skeletal Muscle: Potential Benefits of Nutrient Combination in Ameliorating Muscle Impairment

ChangLiao

LiuXin

LiuJing

et al. 2014

Journal of Medicinal Food

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Accumulating research has shown that chronic D-galactose (D-gal) exposure induces symptoms similar to natural aging in animals. Therefore, rodents chronically exposed to D-gal are increasingly used as a model for aging and delay-of-aging pharmacological research. Mitochondrial dysfunction is thought to play a vital role in aging and age-related diseases; however, whether mitochondrial dysfunction plays a significant role in mice exposed to D-gal remains unknown. In the present study, we investigated cognitive dysfunction, locomotor activity, and mitochondrial dysfunction involved in D-gal exposure in mice. We found that D-gal exposure (125 mg/kg/day, 8 weeks) resulted in a serious impairment in grip strength in mice, whereas spatial memory and locomotor coordination remained intact. Interestingly, muscular mitochondrial complex I deficiency occurred in the skeletal muscle of mice exposed to D-gal. Mitochondrial ultrastructure abnormality was implicated as a contributing factor in D-gal-induced muscular impairment. Moreover, three combinations (A, B, and C) of nutrients applied in this study effectively reversed D-gal-induced muscular impairment. Nutrient formulas B and C were especially effective in reversing complex I dysfunction in both skeletal muscle and heart muscle. These findings suggest the following: (1) chronic exposure to D-gal first results in specific muscular impairment in mice, rather than causing general, premature aging; (2) poor skeletal muscle strength induced by D-gal might be due to the mitochondrial dysfunction caused by complex I deficiency; and (3) the nutrient complexes applied in the study attenuated the skeletal muscle impairment, most likely by improving mitochondrial function.

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Ganoderma atrum polysaccharide attenuates oxidative stress induced by d-galactose in mouse brain

Cited by 40 publications

References 43 publications

Sulfated modification of the polysaccharides from Ganoderma atrum and their antioxidant and immunomodulating activities

Sulfated modification of the polysaccharides from Ganoderma atrum and their antioxidant and immunomodulating activities

Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities

D-Galactose Induces a Mitochondrial Complex I Deficiency in Mouse Skeletal Muscle: Potential Benefits of Nutrient Combination in Ameliorating Muscle Impairment

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