Ganoderma lucidum: Insight into antimicrobial and antioxidant properties with development of secondary metabolites

Ahmad, Md Faruque; A. Alsayegh, Abdulrahman; Ahmad, Fakhruddin Ali; Akhtar, Md Sayeed; Alavudeen, Sirajudeen S.; Bantun, Farkad; Wahab, Shadma; Ahmed, Awais; Ali, M.; Elbendary, Ehab Y.; Raposo, António; Kambal, Nahla; H. Abdelrahman, Mohamed

doi:10.1016/j.heliyon.2024.e25607

Cited by 16 publications

(1 citation statement)

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“…Ganoderma spp. have a diverse variety of phytochemicals, including alkaloids, amino acids, fatty acids, phenolic compounds, proteins and polysaccharides, steroids, and terpenoids, with advantages in food and medicine, including antifungal, antibacterial, antiviral, antidiabetic, antioxidant, immunomodulatory, anti-inflammatory, anti-adipogenic [ 21 ], and anticancer properties [ 22 , 23 , 24 , 25 , 26 ]. This has led to a great deal of curiosity regarding in-depth analysis of this mushroom.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Analysis of Bioactive Compounds in Wild Ganoderma applanatum Mushroom from Kerala, South India: Insights into Dietary Nutritional, Mineral, Antimicrobial, and Antioxidant Activities

Rijia,

Krishnamoorthi,

Rasmi

et al. 2024

Pharmaceuticals

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The present study focused on the mushroom Ganoderma, which has been used in Eastern countries for centuries as a food and medicinal source. Specifically, the fruiting bodies of Ganoderma applanatum from the Kerala Forest Research Institute in Thirussur, Kerala, India, were analyzed for their nutritional and medicinal properties. The methanolic extracts of G. applanatum were used to examine secondary metabolites and proximate profiles, revealing the presence of various phytochemicals such as terpenoids, phenolics, glycosides, alkaloids, flavonoids, and saponins. Further analysis revealed the presence of significant amounts of calcium, sodium, phosphorus, and manganese. The compounds were characterized using chromatographic analysis, FTIR, and GC-MS, which revealed potential therapeutic compounds with C-H and C-O bonds in the amide group, β-glycosides, and C-C/C-O vibrations of phenolic substances. Mushroom extract at a concentration of 100 µg mL−1 exhibited potent antimicrobial activity against various pathogens. This study suggests that G. applanatum has a rich biochemical composition and pharmacological potential, making it a promising candidate for drug development and traditional medicine, and contributes valuable insights into its diverse therapeutic applications.

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