Garcinia cambogia

Raina, Rajinder; Mondhe, Dilip M.; Malik, Jitendra K.; Gupta, Ramesh C.

doi:10.1016/b978-0-12-802147-7.00048-6

Cited by 9 publications

(6 citation statements)

References 82 publications

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“…Los mecanismos que sustentan su efecto anti-obesidad son múltiples. Por una parte, su participación en la regulación de los niveles de serotonina asociados con la saciedad, favorecen los procesos de oxidación de grasas, la disminución de los procesos de novo lipogénesis y, la inhibición de la ATP-citrato liasa (esencial para la síntesis de grasas) 77 . Por otra parte, la lipólisis se favorece mediante el aumento de la actividad de lipasa hepática y de la expresión del receptor alfa activado por proliferante peroxisómico (PGC1α) 71 .…”

Section: Garcinia Cambogia (Garcinia Gummi-gutta)unclassified

Suplementos dietéticos comerciales para el control de sobrepeso: fuentes naturales de fácil acceso, mecanismos de acción y efectos adversos

Riascos

Trujillo

Mendoza

2022

Rev Esp Nutr Hum Diet

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Introducción: El uso de suplementos dietéticos es una de las estrategias actualmente más implementada por la población para contrarrestar el sobrepeso u obesidad debido a su fácil y rápida adquisición en Internet, pese a que muchos de ellos no cuenten con un respaldo científico que justifiquen su efectividad y seguridad. En esta revisión se describen los mecanismos de acción y efectos adversos de los principales suplementos para el control de sobrepeso de venta online en el mercado colombiano. Material y métodos: En las plataformas de compra online: Amazon, eBay, Walmart, Alibaba, Aliexpress y Mercado libre (Colombia), se identificaron las fuentes naturales de los suplementos dietéticos más destacados (Coffea arábica, Camellia sinensis, Garcinia cambogia, Rubus idaeus, Moringa oleifera, Smallanthus sonchifolius, Cinnamomum verum, Capsicum frutescens L, Cynara scolymus, Zingiber officinale y Hibiscus sabdariffa). Se realizó una revisión siguiendo las recomendaciones propuestas por la declaración PRISMA. Las bases de datos utilizadas para la búsqueda de los artículos entre 2010 y 2020 fueron ScienceDirect, PubMed, SCOPUS, SciELO, Web of Science y el buscador Google académico. Un total de 189 referencias fueron contempladas. Resultados: Los principios bioactivos (aislados o en extractos) identificados en las fuentes naturales fueron: polifenoles, teaflavinas, (-)-epigalocatequina-3-O-galato (EGCG), (-)-3-O-(3-O-metil) galato de epigalocatequina (EGCG3), ácido clorogénico, cinamaldehído y ácido hidroxicítrico (HCA), que han demostrado en cultivos celulares y en animales modelo, su capacidad para regular el metabolismo energético, disminuir la lipogénesis, aumentar la oxidación de ácidos grasos e inhibir su síntesis, regular la ingesta de alimentos, entre otras. La hepatotoxicidad y los problemas gastrointestinales con sintomatología leve o moderada, son los efectos adversos más comunes asociados al consumo de este tipo de fuentes. Conclusiones: El efecto en la pérdida de peso de las fuentes naturales abordadas en esta revisión, está científicamente respaldada con ensayos in vitro e in vivo con animales, pero debido al escaso soporte científico evidenciado a partir de ensayos clínicos controlados aleatorizados, es necesario realizar más estudios para establecer la objetividad de lo observado y evaluar la seguridad del uso de los suplementos dietéticos derivados para el control de sobrepeso.

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Section: Garcinia Cambogia (Garcinia Gummi-gutta)unclassified

Suplementos dietéticos comerciales para el control de sobrepeso: fuentes naturales de fácil acceso, mecanismos de acción y efectos adversos

Riascos

Trujillo

Mendoza

2022

Rev Esp Nutr Hum Diet

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“… 9 Nevertheless, several side effects were reported including ocular complications 30 and hepatic toxicity 31 either upon consumption of G . cambogia with multiple ingredients 32 − 34 or due to its concurrent use with other drugs 35 or its administration beyond the recommended doses. 30 …”

Section: Introductionmentioning

confidence: 99%

“… 36 Other health benefits revealed for Garcinia include, e.g ., anti-ulcerogenic, antiseptic, 37 anti-inflammatory, hepatoprotective, antioxidant, erythropoietic, and cytotoxic effect, though most are based on animal studies and less explored in humans to be conclusive compared to the slimming effect reported before. 35 These effects are likely attributed to garcinol, the polyisoprenylated benzophenone that exhibits anti-ulcer, anti-inflammatory, antimicrobial, and anticarcinogenic activities, 5 while the hypolipidemic effect of its flavonoid fraction (10 mg/kg BW/day) in rats exceeded that of Myristica fragrance , Cocos nucifera , and Saraka asoka without exerting any toxic effects. 38 …”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Garcinia cambogia Nutraceuticals in Relation to Its Hydroxy Citric Acid Level. A Comprehensive Review of Its Bioactive Production, Formulation, and Analysis with Future Perspectives

2022

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Garcinia cambogia (Gaertn.) Desr. (known as Malabar tamarind) is a popular traditional herbal medicine and is one of the well-known folk medicines reported for the treatment of obesity and incorporated in several nutraceuticals worldwide. These effects are mediated by a myriad of bioactive compounds with most effects attributed to its hydroxy citric acid (HCA) content. This review aims to present a holistic overview on novel trends in the production of G . cambogia bioactive components and how extraction optimization is important to ensure best product quality with its reported nanoformulations with particular emphasis on HCA content. Further, an overview of the different analytical approaches used for quality control assessment of G . cambogia plant and its nutraceuticals is presented highlighting both advantages and limitations. Moreover, analytical approaches for detecting G . cambogia metabolites in biological fluids with emphasis on HCA level to determine its pharmacokinetics and proof of efficacy are presented for the first time.

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“…The fruit is known to be rich in hydroxycitric acid, with a content up to 30% by weight in the dried and cured pericarp (T. et al, 2017). These rinds are applied in local culinary purposes and are assigned to make more filling meals (Raina et al, 2016). Having no brain accessibility, using hydroxycitric acid appears to be highly acceptable as it causes no CNS side effects.…”

Section: Introductionmentioning

confidence: 99%

Detection and quantification of active pharmaceutical ingredients as adulterants in Garcinia cambogia slimming preparations using NIR spectroscopy combined with chemometrics

Selim

Shawky

El-khair

2020

Records of Pharmaceutical and Biomedical Sciences

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A rapid, simple and efficient method with minimal sample treatment was developed for authentication of Garcinia cambogia fruit peel powder, along with determining undeclared active pharmaceutical ingredients (APIs) in its herbal slimming dietary supplements using near infrared spectroscopy combined with chemometrics. Five featured adulterants, including sibutramine, metformin, orlistat, ephedrine, and theophylline are selected as target compounds. The Near infrared spectral data matrix of authentic Garcinia cambogia fruit peel and specimens degraded by intentional contamination with the five selected APIs was subjected to hierarchical clustering analysis to investigate their bundling figure. SIMCA models were established to ensure the genuiness of Garcinia cambogia fruit peel which resulted in perfect classification of all tested specimens. Adulterated samples were utilized for construction of PLSR models based on different APIs contents at minute levels of fraud practices (LOQ < 0.2% w/w).The suggested approach can be applied to enhance and guarantee the safety and quality of Garcinia fruit peel powder as raw material and in dietary supplements.

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Garcinia cambogia

Cited by 9 publications

References 82 publications

Suplementos dietéticos comerciales para el control de sobrepeso: fuentes naturales de fácil acceso, mecanismos de acción y efectos adversos

Suplementos dietéticos comerciales para el control de sobrepeso: fuentes naturales de fácil acceso, mecanismos de acción y efectos adversos

Recent Advances in Garcinia cambogia Nutraceuticals in Relation to Its Hydroxy Citric Acid Level. A Comprehensive Review of Its Bioactive Production, Formulation, and Analysis with Future Perspectives

Detection and quantification of active pharmaceutical ingredients as adulterants in Garcinia cambogia slimming preparations using NIR spectroscopy combined with chemometrics

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