Garcinone E induces apoptosis and inhibits migration and invasion in ovarian cancer cells

Xu, Xiao‐Huang; Liu, Qian Yu; Li, Ting; Liu, Jianlin; Chen, Xin; Huang, Li; Qiang, Wenan; Chen, Xiuping; Wang, Ying; Li, Lin; Lu, Jin‐Jian

doi:10.1038/s41598-017-11417-4

Cited by 41 publications

(29 citation statements)

References 55 publications

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“…Another two bioactive xanthones from mangosteen are garcinone E and gartanin. Garcinone E has the ability to inhibit ovarian cancer cells and its action involved endoplasmic reticulum-induced stress through protective inositol-requiring kinase (IRE)-1α pathway (Xu et al, 2017). Both invasion and migration properties of the cancer cells were also significantly suppressed when treated with the compound, suggesting its potential use for anti-cancer drug (Xu et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…Garcinone E has the ability to inhibit ovarian cancer cells and its action involved endoplasmic reticulum-induced stress through protective inositol-requiring kinase (IRE)-1α pathway (Xu et al, 2017). Both invasion and migration properties of the cancer cells were also significantly suppressed when treated with the compound, suggesting its potential use for anti-cancer drug (Xu et al, 2017). Furthermore, garcinone E also showed potential anti-cancer activity against cervical, hepatoma, gastric (Ying et al, 2017), breast, colorectal, and hepatocellular (Mohamed et al, 2017) cancer cell lines.…”

Section: Introductionmentioning

confidence: 99%

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Recent updates on metabolite composition and medicinal benefits of mangosteen plant

Aizat¹,

Jamil²,

Ahmad-Hashim³

et al. 2019

PeerJ

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Background Mangosteen (Garcinia mangostana L.) fruit has a unique sweet-sour taste and rich in beneficial compounds such as xanthones. Mangosteen has been originally used in various folk medicines to treat diarrhea, wound, and fever. More recently, it has been used as a major component in health supplement products for weight loss and promoting general health. This is perhaps due to its known medicinal benefits including as anti-oxidant and anti-inflammation. Interestingly, the publications related to mangosteen has surged in recent years suggesting its popularity and usefulness in research laboratories. However, there is still no updated reviews (up to 2018) in this booming research area, particularly on its metabolite composition and medicinal benefits. Method In this review, we have covered recent articles within the year of 2016 to 2018, which focuses on several aspects including the latest findings on compound composition from mangosteen fruit as well as its medicinal usages. Result Mangosteen has been vastly used in medicinal areas including as anti-cancer, anti-microbial, and anti-diabetes treatments. Furthermore, we have also described the benefits of mangosteen extract in protecting various human organs such as liver, skin, joint, eye, neuron, bowel, and cardiovascular tissues against disorders and diseases. Conclusion All in all, this review describes the numerous manipulations of mangosteen extracted compounds in medicinal areas and highlights the current trend of its research. This will be important for future directed research and may allow researchers to tackle the next big challenge in mangosteen study; drug development and human applications.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Recent updates on metabolite composition and medicinal benefits of mangosteen plant

Aizat¹,

Jamil²,

Ahmad-Hashim³

et al. 2019

PeerJ

View full text Add to dashboard Cite

show abstract

“…(Ho et al, 2002). Recent study indicates that Garcinone E could induce apoptotsis and inhibit invasion in cervical cancer cell progression (Xu et al, 2017). No study has been conducted to exploit the effect of Garcinone E on oral cancer cells.…”

Section: Antimetastatic Potential Of Garcinone E In Human Oral Cancermentioning

confidence: 99%

Antimetastatic Potential of Garcinone E in Human Oral Cancer Cells

Sheeja

Lakshmi

2019

Asian Pac J Cancer Prev

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Objective: Oral cancer presents as a devastating type of malignancy. It is predominant in populations with high use of alcohol and various forms of tobacco as well as poor diets with low intake of fruits and vegetables. The present study focused on the potential of Garcinone E to inhibit HSC-4 oral cancer cell proliferation, migration and invasion. Methods: MTT and colony forming assays were performed to study antiproliferative effects of Garcinone E. Hoechst staining was used to determine levels of apoptosis, with cell invasion and scratch assays conducted for migration and invasion characteristics. The levels of MMPs and cytokines were quantified in Garcinone E treated cells by ELISA. Results: Garcinone E inhibited the proliferation and colony forming potential of HSC-4 cells. It also suppressed migration and invasion with inhibition of MMP-2 and MMP-9 expression. Moreover, it elevated IL-2 and reduced IL-6 expression in HSC-4 cells. Conclusion: Our results demonstrate for the first time that Garcinone E might inhibit metastasis of an oral cancer cell line by blocking invasion, migration and MMP production.

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“…Garcinone E has the ability to inhibit ovarian cancer cells and its action involved endoplasmic reticulum induced stress through protective inositol-requiring kinase (IRE)-1α pathway (Xu et al 2017). Both invasion and migration properties of the cancer cells were also significantly suppressed when treated with the compound, suggesting its potential use for anti-cancer drug (Xu et al 2017).…”

Section: Medicinal Usages Of Mangosteenmentioning

confidence: 99%

Peer Review #2 of "Recent updates on metabolite composition and medicinal benefits of mangosteen plant (v0.2)"

2019

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Background. Mangosteen (Garcinia mangostana L.) fruit has unique sweet-sour taste and rich in beneficial compounds such as xanthones. Mangosteen has been originally used in various folk medicines to treat diarrhea, wound and fever. More recently, it has been used as a major component in health supplement products for weight loss and promoting general health. This is perhaps due to its known medicinal benefits including as anti-oxidant and anti-inflammation. Interestingly, the publications related to mangosteen has surged in recent years suggesting its popularity and usefulness in research laboratories. However, there is still no updated reviews (up to 2018) in this booming research area, particularly on its metabolite composition and medicinal benefits. Method. In this review, we have covered recent articles within the year of 2016 to 2018, which focuses on several aspects including the latest findings on compound composition from mangosteen fruit as well as its medicinal usages. Result. Mangosteen has been vastly used in medicinal area including as anti-cancer, anti-microbial and anti-diabetes treatments. Furthermore, we have also described the benefits of mangosteen extract in protecting various human organs such as liver, skin, joint, eye, neuron, bowel and cardiovascular tissues against disorders and diseases. Conclusion. All in all, this review describes the numerous manipulations of mangosteen extracted compounds in medicinal areas and highlights the current trend of its research. This will be important for future directed research and may allow researchers to tackle the next big challenge in mangosteen study; drug development and human applications.

show abstract

Garcinone E induces apoptosis and inhibits migration and invasion in ovarian cancer cells

Cited by 41 publications

References 55 publications

Recent updates on metabolite composition and medicinal benefits of mangosteen plant

Recent updates on metabolite composition and medicinal benefits of mangosteen plant

Antimetastatic Potential of Garcinone E in Human Oral Cancer Cells

Peer Review #2 of "Recent updates on metabolite composition and medicinal benefits of mangosteen plant (v0.2)"

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