Gardner–Diamond syndrome

Autoerythrocyte sensitization syndrome is a psychologically induced painful bruising condition. Two female, 19 and 30-year-old presented with recurrent episodes of painful ecchymotic bruising over accessible areas of body. In the younger female, episodes were since 3 years and were precipitated by stress and trivial trauma. The elder female presented with similar lesions since 3 months which were spontaneous in presentation. There were no obvious psychiatric manifestations in either. Clinically, ecchymotic changes in various stages of development were seen. Routine hemogram and coagulation profile were normal. Histopathology showed extravasated erythrocytes, perivascular neutrophils and fibrinoid deposition. Intradermal injection of autologous whole blood produced a painful ecchymotic reaction after 2 h similar to the presenting lesions. Psychiatric evaluation revealed mild mixed depression – anxiety disorder in the younger female while the latter revealed no abnormalities. The diagnosis of autoerythrocyte sensitization syndrome was made based on clinical history and findings, positive autoerythrocyte sensitization test, psychiatric evaluation and absence of any other clinical or laboratory pathology.

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Perplexing purpura in two females: Rare case of autoerythrocyte sensitization syndrome

Tainwala

Phiske

Raghuwanshi

et al. 2013

Indian Dermatol Online J

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Gardner-Diamond syndrome: case report

Öztürk¹,

Akman²,

Sayar³

2012

Gaziantep Med J

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ÖzetGardner-Diamond Sendromu (otoeritrosit sensitizasyon sendromu) genellikle genç kadınlarda tekrarlayan, ağrılı ekimotik plaklarla karakterize bir hastalıktır. Ekimozlar, özellikle emosyonel stres veya hafif travma sonrasında spontan olarak ortaya çıkar. En sık tutulan bölgeler ekstremitelerdir. Burada Gardner-Diamond Sendromu ile birlikte yaygın anksiyete ve depresyon tanısı alan 25 yaşındaki olgu sunularak, nadir görülen bu hastalığın psikiyatrik bozukluklarla bağlantısına dikkat çekildi ve literatür gözden geçirildi. Anahtar kelimeler: Anksiyete; Depresyon; Gardner-Diamond Abstract Gardner-Diamond syndrome is characterized with recurrent, painful, ecchymotic plaques usually seen in young women. Ecchymosis spontaneously occurs after emotional stress and mild trauma. The lesions mostly seen in extremities. In this case, 25 year old patient diagnosed with Gardner-Diamond syndrome with depression and anxiety is presented. Attention has been drawn to this disease in connection with psychiatric disorders and also the literature was reviewed.

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Gardner–Diamond syndrome

Cited by 2 publications

References 7 publications

Perplexing purpura in two females: Rare case of autoerythrocyte sensitization syndrome

Perplexing purpura in two females: Rare case of autoerythrocyte sensitization syndrome

Gardner-Diamond syndrome: case report

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