Garlic Inhibits Microsomal Triglyceride Transfer Protein Gene Expression in Human Liver and Intestinal Cell Lines and in Rat Intestine

Lin, Marie C.; Wang, Erjia; Lee, Catherine; Chin, Koo-Bok; Liu, Depei; Chiu, Jen‐Fu; Kung, Hsiang-Fu

doi:10.1093/jn/132.6.1165

Cited by 52 publications

(32 citation statements)

References 33 publications

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“…42 Various garlic extracts have been shown to decrease the activities of NADPH-producing enzymes and of fatty acid synthetase in vitro and in vivo. 17,18,43 It has also been postulated that the plasma TG lowering effect may also be, in part, due to decreases in intestinal microsomal TG transfer protein mRNA 44 and apolipoprotein B100 secretion. 14 Over-production of apolipoprotein B100 containing lipoproteins can lead to atherosclerosis and coronary heart disease and also induces hyperlipidaemia.…”

Section: Discussionmentioning

confidence: 99%

Consumption of raw brown onions variably modulate plasma lipid profile and lipoprotein oxidation in pigs fed a high‐fat diet

Gabler

Ostrowska²,

Sterling³

et al. 2004

J Sci Food Agric

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This study was undertaken to determine the effects of two commercially available brown onion varieties, 'Cavalier' and 'Destiny', supplemented at two different levels, on blood lipid and oxidative status using the pig as a model. Twenty-five female cross-bred pigs were allocated to one of five dietary treatments that consisted of a high-fat control diet with no onion added, a low onion dose of 10 g onion MJ −1 DE and a high dose of 25 g onion MJ −1 DE for each variety of onion. Supplementation with 'Destiny' onion resulted in a 21% (p < 0.05) reduction in the averaged fasted and postprandial plasma triacylglyceride (TG) measurements taken over the six-week period in comparison with the control pigs. The average fasting and postprandial plasma cholesterol concentrations were significantly reduced by 5.5 and 12.4% in pigs that consumed the low and high dose of 'Destiny' onion, respectively (p < 0.010), while 'Cavalier' was only effective at lowering cholesterol levels by 10% at the lower dose of supplementation. Inhibition in the rate of serum lipoprotein oxidation, measured as lag time, was increased by 23% (p < 0.05) in plasma obtained from pigs that consumed 'Cavalier' compared with the control and 'Destiny' onion diets. These data indicate that onion consumption level may provide a dietary means of manipulating some of the risk indices associated with coronary heart disease, but the responses varied with type and dose of onion.

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Section: Discussionmentioning

confidence: 99%

Consumption of raw brown onions variably modulate plasma lipid profile and lipoprotein oxidation in pigs fed a high‐fat diet

Gabler

Ostrowska²,

Sterling³

et al. 2004

J Sci Food Agric

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“…It is an edible wild plant that belongs to family Portulaceae. The leaves of purslane are commonly used as food staff, since they contain high ratio of ascorbic acid [162]. Purslane extract in the form of ethanolic formulation is rich in polyphenols, flavonoids and anthocyanin, ω-3 fatty acids, and melatonin.…”

Section: Purslanementioning

confidence: 99%

Obesity and Clinical Riskiness Relationship: Therapeutic Management by Dietary Antioxidant Supplementation—a Review

Hassan

El-Gharib

2015

Appl Biochem Biotechnol

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Obesity is a global health problem affecting all age groups, leading to many complications such as type 2 diabetes, systemic hypertension, cardiovascular disease, dyslipidemia, atherosclerosis, and stroke. Physiologically, obesity arises from metabolic changes in the tissues and organs of the human body; these changes result in an imbalance between energy intake and energy expenditure, which in turn results in increased fat accumulation in adipose tissue. Such fat accumulation predisposes individuals to development of several health problems. Two different obesity treatment drugs are currently on the market; Orlistat, which reduces intestinal fat absorption via inhibiting pancreatic lipase, and Sibutramine, an anorectic or appetite suppressant. Both drugs have hazardous side effects, including increased blood pressure, dry mouth, constipation, headache, and insomnia. For this reason, a wide variety of natural materials have been explored for their obesity treatment potential. Therefore, the present review focuses on the safety and efficacy of some herbal medicines in the management of obesity through covering their beneficial effects and mechanism of action.

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“…Saponin fractions from garlic lowered plasma total and LDL cholesterol concentrations without changing HDL cholesterol levels in a hypercholesterolaemic animal model (Matsuura 2001 ). In-vivo studies in rats suggested that long-term dietary supplementation of fresh garlic may exert a lipid-lowering effect partly through reducing intestinal MTP mRNA gene expression, thus, suppressing the assembly and secretion of chylomicrons from the intestine to the blood circulation (Lin et al 2002 ). In-vitro, fresh garlic extract reduced MTP mRNA levels in both the human hepatoma HepG2 and intestinal carcinoma Caco-2 cells in a dosedependent fashion.…”

Section: Animal Studiesmentioning

confidence: 99%

Allium sativum

Lim¹

2014

Edible Medicinal and Non Medicinal Plants

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Garlic Inhibits Microsomal Triglyceride Transfer Protein Gene Expression in Human Liver and Intestinal Cell Lines and in Rat Intestine

Cited by 52 publications

References 33 publications

Consumption of raw brown onions variably modulate plasma lipid profile and lipoprotein oxidation in pigs fed a high‐fat diet

Consumption of raw brown onions variably modulate plasma lipid profile and lipoprotein oxidation in pigs fed a high‐fat diet

Obesity and Clinical Riskiness Relationship: Therapeutic Management by Dietary Antioxidant Supplementation—a Review

Allium sativum

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