Gartanin Compounds from Extract Ethanol Pericarp Mangosteen (Garcinia mangostana Linn.)

Oetari, R.A.; Hasriyani, Hasriyani; Prayitno, Adi; Sahidin, Sahidin

doi:10.3889/oamjms.2019.527

Cited by 8 publications

(7 citation statements)

References 16 publications

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“…Isocolumbin is a natural alkaloids targeting the epidermal growth factor receptor in nonsmall cell lung cancer . Gartanin, which is first identified in the purple mangosteen fruit, is a potent growth inhibitor of various cancer cell lines. , In T. cuspidata, isocolumbin and gartanin are two vascular bundle cell specifically accumulated active compounds (>90%), suggesting their movement between plant tissues.…”

Section: Resultsmentioning

confidence: 99%

“… 40 Gartanin, which is first identified in the purple mangosteen fruit, is a potent growth inhibitor of various cancer cell lines. 41 , 42 In T. cuspidata , isocolumbin and gartanin are two vascular bundle cell specifically accumulated active compounds (>90%), suggesting their movement between plant tissues. Procyanidin B2 is a potent natural antioxidant exhibiting multiprotective roles in response to vitrification stimuli.…”

Section: Resultsmentioning

confidence: 99%

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Mass Spectrometry-Imaging Analysis of Active Ingredients in the Leaves of Taxus cuspidata

Zhan,

Zang,

et al. 2024

ACS Omega

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Background: Taxus cuspidata is an endangered evergreen conifer mainly found in Northeast Asia. In addition to the well-known taxanes, several active ingredients were detected in the leaves of T. cuspidata. However, the precise spatial distribution of active ingredients in the leaves of T. cuspidata is largely unknown. Results: in the present study, timsTOF flex MALDI-2 analysis was used to uncover the accumulation pattern of active ingredients in T. cuspidata leaves. In total, 3084 ion features were obtained, of which 944 were annotated according to the mass spectrometry database. The principal component analysis separated all of the detected metabolites into four typical leaf tissues: mesophyll cells, upper epidermis, lower epidermis, and vascular bundle cells. Imaging analysis identified several leaf tissues that specifically accumulated active ingredients, providing theoretical support for studying the regulation mechanism of compound biosynthesis. Furthermore, the relative accumulation levels of each identified compound were analyzed. Two flavonoid compounds, ligustroflavone and Morin, were identified with high content through quantitative analysis of the ion intensity. Conclusions: our data provides fundamental information for the protective utilization of T. cuspidata.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Mass Spectrometry-Imaging Analysis of Active Ingredients in the Leaves of Taxus cuspidata

Zhan,

Zang,

et al. 2024

ACS Omega

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“…The VLC showed that the yield of each fraction is due to the chemical composition and the equilibrium of the phases (mobile and stationary) [ 33 ]. Although VLC is used to separate extracts from other plants, our study describes the yield of separated fractions for the first time [ 34 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

Antibacterial Potential by Rupture Membrane and Antioxidant Capacity of Purified Phenolic Fractions of Persea americana Leaf Extract

et al. 2021

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The present research focused on evaluating the antibacterial effect and the mechanism of action of partially purified fractions of an extract of Persea americana. Furthermore, both its antioxidant capacity and composition were evaluated. The extract was fractionated by vacuum liquid chromatography. The antimicrobial effect against Staphylococcus aureus (ATCC 6538), Escherichia coli (ATCC 11229), Pseudomonas aeruginosa (ATCC 15442), and Salmonella choleraesuis (ATCC 1070) was analyzed by microdilution and the mechanism of action by the Sytox green method. The antioxidant capacity was determined by DPPH, FRAP, and ABTS techniques and the composition by Rp-HPLC-MS. All fractions showed a concentration-dependent antibacterial effect. Fractions F3, F4, and F5 (1000 µg/mL) showed a better antibacterial effect than the extract against the bacteria mentioned. The F3 fraction showed inhibition of 95.43 ± 3.04% on S. aureus, F4 showed 93.30 ± 0.52% on E. coli, and F5 showed 88.63 ± 1.15% on S. choleraesuis and 86.46 ± 3.20% on P. aeruginosa. The most susceptible strain to the treatment with the extract was S. aureus. Therefore, in this strain, the bacterial membrane damage induced by the extract and fractions was evidenced by light fluorescence microscopy. Furthermore, the extract had better antioxidant action than each fraction. Finally, sinensitin was detected in F3 and cinnamoyl glucose, caffeoyl tartaric acid, and cyanidin 3-O-(6′′-malonyl-3′′-glucosyl-glucoside) were detected in F4; esculin and kaempferide, detected in F5, could be associated with the antibacterial and antioxidant effect.

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“…Gartanin is a xanthone derivative found in the pericarp of the mangosteen fruit and leaves of Garcinia mangostana . It exhibits various pharmacological activities, including antifungal, antioxidant, and anticancer properties against bladder and lung cancers .…”

Section: Introductionmentioning

confidence: 99%

A Comprehensive Multispectroscopic and Computational Analysis of the Interaction between Plant-Based Antiplasmodial Compounds and Bovine Serum Albumin

Azeem,

Abdulhameed,

Hussain

et al. 2024

ACS Omega

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This study was conducted to explore the interaction between two plant-based antiplasmodial compounds, gartanin and friedelin, and bovine serum albumin (BSA). The objectives aimed to elucidate the binding characteristics, structural changes, and thermodynamic parameters associated with the interaction. Various methods were used including UV−vis, fluorescence, and circular dichroism spectroscopy, supported by molecular docking and molecular dynamics simulation. The results showed a concentration-dependent interaction between the antiplasmodial compounds and BSA, revealing changes in protein conformation and stability. The obtained results showed that the plant products bound with BSA through static quenching with moderate binding affinity (10 4 M −1 ) with BSA. Thermodynamic parameters and structural transitions calculated from spectroscopic methods revealed that hydrogen bond and van der Waals forces caused the partial conformational alteration in the secondary structure of BSA as the α-helical content decreased with an increase in β sheets, random coils, and other structures. Computational analysis provided insights into the binding sites and affinities. The study enhances our understanding of the molecular interactions between BSA protein and antiplamodial compounds obtained from plants, supporting the research of choosing, designing, and optimizing molecules for biomedical applications with a focus on selectively targeting their binding sites.

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Gartanin Compounds from Extract Ethanol Pericarp Mangosteen (Garcinia mangostana Linn.)

Cited by 8 publications

References 16 publications

Mass Spectrometry-Imaging Analysis of Active Ingredients in the Leaves of Taxus cuspidata

Mass Spectrometry-Imaging Analysis of Active Ingredients in the Leaves of Taxus cuspidata

Antibacterial Potential by Rupture Membrane and Antioxidant Capacity of Purified Phenolic Fractions of Persea americana Leaf Extract

A Comprehensive Multispectroscopic and Computational Analysis of the Interaction between Plant-Based Antiplasmodial Compounds and Bovine Serum Albumin

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