Gas chromatographic methods for analysis of sulfone drugs used in leprosy chemotherapy

Characterization of 4,4'-dichlorodiphenyl sulfone impurities by gas chromatography and mass spectrometry

“…This shortcoming of TLC prompted Gordon and Peters to use microbore column chromatography to determine DDS, 4-amino-4,-acetamidodiphenyl sulfone (MADDS), and 4,4'-diacetamidodiphenyl sulfone (DADDS) in urine (12). Burchfield and coworkers extended the analysis of DDS and MADDS by converting these aminosulfones and their respective meta isomers (added as internal standards) to the corresponding iodo derivatives and determining them by gas chromatography (13). Gas chromatography has also been used by Cates and Meloan to resolve nonisomeric sulfoxides and sulfones (14,15) and by Wallace and Mahon to separate nonisomeric sulfoxides, sulfones, and sulfides (16).…”