Gastric and small bowel ileus after severe burn in rats: The effect of cyclooxygenase-2 inhibitors

Oliveira, Hermes M.; Sallam, Hanaa S.; Espana-Tenorio, Jonathan M.; Chinkes, David L.; Chung, Dai H.; Chen, Jiande D.Z.; Herndon, David N.

doi:10.1016/j.burns.2009.02.022

Cited by 22 publications

(34 citation statements)

References 27 publications

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“…Nevertheless, the Walker-Mason scald burn murine model has been well recognized [6,17]; plus our data on hematocrit confirm significant plasma loss and associated hemo-concentration consistent with the published data on this model. Opioids may have acted as a confounding factor in the current study.…”

Section: Discussionsupporting

confidence: 94%

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Gastric Emptying and Intestinal Transit of Various Enteral Feedings Following Severe Burn Injury

2011

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Section: Discussionsupporting

confidence: 94%

“…In the methylcellulose-treated rats, gastric emptying was severely delayed at 1 and 6 h after burn, in agreement with our previous studies [6,17]. This data show that burninduced gastric inhibition occurs early post-burn and persists over time.…”

Section: Discussionsupporting

confidence: 93%

Gastric Emptying and Intestinal Transit of Various Enteral Feedings Following Severe Burn Injury

2011

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“…The guinea pigs were subjected to a 24-hour fast with free access to water before the experiments. [13][14][15] The animals assigned as the control group were administered anesthesia only. The sham group underwent laparotomy under anesthesia without manipulation of the cecum.…”

Section: Preparation and Handling Of Different Groups Of Animalsmentioning

confidence: 99%

Inflammation, Impaired Motility, and Permeability in a Guinea Pig Model of Postoperative Ileus

Lee

Hussain

Huh

et al. 2018

J Neurogastroenterol Motil

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Background/AimsPostoperative ileus (POI) is characterized by impaired propulsive function of the gastrointestinal tract after surgery. Although inflammation is considered to be an important pathogenesis of POI, significant data are lacking. We aim to correlate the recovery time of postoperative dysmotility with that of inflammation and mucosal permeability. MethodsAn experimental POI model of guinea pig was used. Contractile activity of the circular muscle of the stomach, jejunum, ileum, and proximal colon was measured through a tissue bath study. Inflammatory cells were counted, and the expression of calprotectin and tryptase were analyzed. The expression of protease-activated receptor 2 (PAR-2), claudin-1, and claudin-2 were analyzed with immunofluorescence. ResultsThe small bowel and colon showed decreased contractile amplitude in the POI groups compared to control. In contrast to the colon, the contractile amplitude of the small bowel significantly recovered in the POI group at 6 hours after the operation compared to the control group. Inflammation was highly significant in the POI groups compared to the control and sham groups, especially in the colon. Immunofluorescence showed increased PAR-2 expression in the POI groups compared to sham. The decreased claudin-1 expression and increased claudin-2 expression may suggest increased mucosal permeability of the small bowel and colon in the POI groups. ConclusionsIncreased inflammation and mucosal permeability may play an important role in the differential recovery stages in POI. These data may provide further insights into the pathophysiology and potential new therapeutic prospects of POI. (J Neurogastroenterol Motil 2018;24:147-158)

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“…More than half of the studies used this therapy, indicating the importance of this procedure for experiments with later evaluation -this related to third degree burns and burns of large surface areas -as was the case when a 60% burn area was produced, generating great hemodynamic instability as in clinical conditions [33][34][35] .…”

Section: Post-burn Time Intervalmentioning

confidence: 99%

Rat an experimental model for burns: A systematic review

Mitsunaga

Gragnani

Ramos³

et al. 2012

Acta Cir. Bras.

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PURPOSE:To revise and systematize scientific knowledge of the experimental model for cutaneous burns in rats. METHODS:A bibliographical review from 2008 up to January 2011 in PubMed, EMBASE and LILACS was undertaken. Were used the keywords: animal models, burns and rats. 221 studies were identified, and 116 were selected. RESULTS:It was found that: 54/86 (62.7%) had third degree burns; 55/73 (75.3%) studied the back; 45/78 (57.6%) used heated water and 27/78 (35.9%) incandescent instruments; 39/78 (50%) studied systemic effects; 22/71 (31%) used ketamine associated with xylazine; 61/64 (95.3%) performed depilation with appropriate equipment; 36/72 (50%) used microscopy; more than 50% did not describe analgesia or antibiotics during the postoperative period; in 42/116 (36.2%) postoperative fluid therapy was performed; and the time interval after the burn, up to the beginning of the results analysis varied from 7s up to four weeks. Legislation issues on burn experiments are discussed. CONCLUSION:The hot water was the main method to induce burns those of third degree on the back, with anesthesia using ketamine and xylazine, after depilation. These were evaluated microscopically, without using analgesia or an antibiotic during the postoperative period. The studies were not very reproducible. CONCLUSÃO: Líquido aquecido foi o principal método para induzir queimadura de terceiro grau no dorso do animal, com anestesia usando quetamina e xilazina, após depilação, avaliados por microscopia, sem uso de analgesia ou antibióticos. Os estudos não são reprodutíveis.Descritores: Modelos Animais. Queimaduras. Pele. Revisão. Ratos.Mitsunaga Jr JK et al.

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Gastric and small bowel ileus after severe burn in rats: The effect of cyclooxygenase-2 inhibitors

Cited by 22 publications

References 27 publications

Gastric Emptying and Intestinal Transit of Various Enteral Feedings Following Severe Burn Injury

Gastric Emptying and Intestinal Transit of Various Enteral Feedings Following Severe Burn Injury

Inflammation, Impaired Motility, and Permeability in a Guinea Pig Model of Postoperative Ileus

Rat an experimental model for burns: A systematic review

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