Gastric angiomyolipoma: a previously undescribed cause of upper GI hemorrhage

Helwig, K.

doi:10.1016/s0002-9270(98)00181-6

Cited by 3 publications

(8 citation statements)

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“…To our knowledge, only 3 cases have been reported in the literature. Because of the vascular nature of the tumor, GAML has a predilection to present with upper GI bleeding 6. This was seen in our case and also described previously 2 , 7.…”

Section: Discussionsupporting

confidence: 85%

“…As many as 20% of symptomatic patients present with shock. Diagnosis with endoscopy can be difficult because of nonspecific mucosal features and inadequate depth on routine biopsy specimens 6. Two of the previously reported cases of GAML were polypoidal on EGD with central ulceration located in the gastric body and the pylorus, respectively 2 , 7.…”

Section: Discussionmentioning

confidence: 99%

“…Two of the previously reported cases of GAML were polypoidal on EGD with central ulceration located in the gastric body and the pylorus, respectively 2 , 7. Another case reported a mass with ulceration in the antrum 6. Endoscopic ultrasound (EUS) is preferred over EGD for evaluation of submucosal lesions because it differentiates the 5 layers of the gastric wall, which helps in identifying the layer of origin of the lesion and yields information about the echotexture of mass.…”

Section: Discussionmentioning

confidence: 99%

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Gastric Angiomyolipoma Masquerading as Gastric Malignancy

Ail

Paulose

Kalitha

et al. 2018

ACG Case Reports Journal

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Gastric angiomyolipoma (AML) is extremely rare, with only 3 cases reported in English literature, all of which presented with upper gastrointestinal bleed, either in the form of hematemesis or melena. A 42-year-old man presented with upper gastrointestinal bleed, the source of which was found to be a large mass in the stomach, which was shown histologically to be gastric AML. This is the fourth but largest tumor (9 × 6 × 5 cm) to be reported to date.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Gastric Angiomyolipoma Masquerading as Gastric Malignancy

Ail

Paulose

Kalitha

et al. 2018

ACG Case Reports Journal

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“…The two most commonly affected organs are kidney and liver accounting > 90% of the cases [ 3 ]. In the gastrointestinal tract, other than in liver, it was reported in duodenum, appendix, pancreas and stomach [ 3 - 5 ]. Gastric angiomyolipoma (GAML) is extremely rare and was reported only twice in the literature [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…In the gastrointestinal tract, other than in liver, it was reported in duodenum, appendix, pancreas and stomach [ 3 - 5 ]. Gastric angiomyolipoma (GAML) is extremely rare and was reported only twice in the literature [ 4 , 5 ]. Here, we report the third case of GAML with typical histopathological features.…”

Section: Introductionmentioning

confidence: 99%

Gastric Angiomyolipoma, a Very Rare Cause of Upper Gastrointestinal Bleeding: A Case Report and a Brief Review of Literature

Veera

Bemalgi

2012

Gastroenterology Research

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Angiomyolipoma (AML) is a tumor composed of variable proportions of adipose tissue, spindle and epithelioid smooth muscle-like cells and abnormal thick-walled blood vessels which are usually benign. AML is relatively common in kidney and liver. Gastric angiomyolipoma (GAML) is extremely rare and only 2 cases were reported in the literature. Diagnosis of AML is difficult owing to its rarity and varied immunohistochemical patterns. Here, we report a case of GAML in a 65-year-old male who presented with an episode of hematemesis and intermittent melena for one week. Endoscopy showed a partially obstructing mass arising from gastric antrum with central ulceration. Mass was removed by wedge resection after laparoscopic anterior gastrectomy. Excised specimen showed a benign 6 × 3 × 3 cm homogenous fatty mass with adipose tissue, smooth muscles and prominent vascularity. Immunohistochemistry stains were positive for desmin, smooth muscle actin (SMA), CD34 and negative for human melanoma black (HMB)-45 antigen and CD117. This case reports the largest and HMB-45 negative GAML so far, which can be a very rare cause of upper gastrointestinal bleeding.

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Synchronous cutaneous malignant peripheral nerve sheath tumor and jejunal gastrointestinal stromal tumor and submucosal angiomyolipoma in type 1 neurofibromatosis: A case report and literature review

Kim

Rao

et al. 2023

Medicine

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Rationale: Type 1 neurofibromatosis (NF1) is one of the most prevalent genetic conditions. NF1 is characterized by cutaneous plexiform neurofibromas and café au lait skin pigmentation, and is inherited in an autosomal dominant trait with mutation in the neurofibromin 1 gene on chromosome 17. Neurofibromin is involved in Ras proto-oncogene regulation. Accordingly, NF1 may lead to malignancies, with a lifetime cancer risk of 60%. Malignant peripheral nerve sheath tumor (MPNST) is the leading cause of mortality due to NF1. The relevance of gastrointestinal stromal tumor (GIST) in NF1 is increasingly being reported in the literature and NF1-associated GIST has been identified to have an alternative molecular pathogenesis.Patient concerns: A 62-years-old female had a 7 × 5 cm growing back mass in the background of various sized cutaneous neurofibromas with café au lait spots. Computed tomography performed in the workup revealed a 4.1 cm enhancing mass near the ileal mesentery.Diagnoses: NF1 affected by cutaneous MPNST of the back, and synchronous GIST and submucosal angiomyolipoma (AML) of the jejunum. Interventions:The patient underwent laparoscopic jejunal mass excision, and excision and flap coverage for the back mass owing to the suspicion of multiple MPNSTs. However, the abdominal masses were diagnosed as GIST and AML following confirmation of the immunohistochemical profiles. Accordingly, the patient was administered adjuvant radiotherapy to the MPNST after surgery.Outcomes: Symptomatic improvements were achieved, and no subsequent relapses were observed.Lessons: Although MPNST and GIST are not rare neoplasm in NF1, only 2 case reports have been published on the synchronous occurrence of these tumors. Moreover, no case report has been published on AML in NF1, except 1 renal AML in segmental neurofibromatosis. Identifying the clinical and pathologic significances of the NF1 is important to achieve improved diagnostic accuracy.

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Gastric angiomyolipoma: a previously undescribed cause of upper GI hemorrhage

Abstract: Angiomyolipomas are rare lesions often arising in the kidney. We describe the first documented case of symptomatic gastric angiomyolipoma.

Cited by 3 publications

References 0 publications

Gastric Angiomyolipoma Masquerading as Gastric Malignancy

Gastric Angiomyolipoma Masquerading as Gastric Malignancy

Gastric Angiomyolipoma, a Very Rare Cause of Upper Gastrointestinal Bleeding: A Case Report and a Brief Review of Literature

Synchronous cutaneous malignant peripheral nerve sheath tumor and jejunal gastrointestinal stromal tumor and submucosal angiomyolipoma in type 1 neurofibromatosis: A case report and literature review

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