Gastric Anisakiasis

Hirosawa, Takanobu; Sakamoto, Tetsu; Shimizu, Taro

doi:10.1016/j.amjms.2020.04.021

Cited by 5 publications

(5 citation statements)

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“…These infections are characterized as a zoonotic disease called anisakiasis or anisakidosis [ 26 ]. Depending on a number of factors, such as the location of the parasites, their subsequent migration through the body, and host’s immune response, anisakidosis can be presented as either intestinal, gastric, or allergic, with different symptoms varying from mild to severe [ 27 , 28 , 29 ]. Reports of such infections have been increasing in frequency [ 25 , 30 ], most likely as a result of the increasing consumption of raw and undercooked fish around the world [ 31 , 32 ], as well as Croatia [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

The Influence of Contracaecum larvae (Nematoda, Anisakidae) Parasitism on the Population of Prussian carp (Carassius gibelio) in Lake Sakadaš, Croatia

et al. 2022

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Contracaecum larvae are geographically widely distributed, utilizing many animal species as hosts; and fish represent an important paratenic host in their life cycle. Their presence in Prussian carp (Carassius gibelio) was studied in Lake Sakadaš (Croatia) in 2017 and 2018. Two gill nets of different sizes submerged during a 12-h period were used to collect the fish. Contracaecum larvae were recorded in the stomach, slightly coiled or elongated on the intestine serosa or encapsulated in a gut wall of 20 individuals. The effect of Contracaecum sp. on the health of their host was determined by estimating the effect of the parasites’ presence, number, and biomass on fish length, weight, and the Fulton’s condition factor (CF). Infected fish showed negative (b < 3; p < 0.05) and uninfected fish positive allometric growth (b > 3; p < 0.05). Fish weight and CF in infected individuals were significantly low in comparison to the uninfected ones (Mann–Whitney U test: U = 1078.00, U = 423.50, respectively; p < 0.004). These results emphasize the importance of evaluating parasitic nematode presence in economically important fish species. Even more, if this endoparasite has a detectable negative impact on a resilient species such as the Prussian carp, it is important to monitor its occurrence in other fish species.

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Section: Introductionmentioning

confidence: 99%

The Influence of Contracaecum larvae (Nematoda, Anisakidae) Parasitism on the Population of Prussian carp (Carassius gibelio) in Lake Sakadaš, Croatia

et al. 2022

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“…Anisakiasis can be confirmed by detecting the morphological characteristics of the whole worm on endoscopy [ 3 , 5 ]. Different from gastric anisakiasis, intestinal anisakiasis is difficult to diagnose because the small intestine is an inaccessible zone for endoscopy.…”

Section: Discussionmentioning

confidence: 99%

“…The clinical imaging findings in intestinal anisakiasis are remarkable, including ascites, enteritis, ileus, eosinophilic granuloma and sometimes perforation [ 5 ]. Patients with intestinal perforations or strangulation normally require surgical therapy, but conservative therapy can be the treatment option in anisakiasis [ 3 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…Patients with intestinal perforations or strangulation normally require surgical therapy, but conservative therapy can be the treatment option in anisakiasis [ 3 , 6 ]. Cases of nongastric anisakiasis are not only rare but also difficult to diagnose because the small intestine is unreachable by a regular endoscope, although detecting the whole worm visually is the hallmark of the diagnostic procedure [ 3 , 5 ]. As a result, patients with intestinal anisakiasis diagnosed as acute abdomen or intestinal obstructions might undergo unnecessary surgical operations.…”

Section: Introductionmentioning

confidence: 99%

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Fifty-millimeter abscess in the ileum caused by perforation from anisakiasis successfully treated with conservative therapy without drainage

Kawanishi¹,

Ikeda²,

Furotani³

et al. 2021

Oxford Medical Case Reports

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Intestinal anisakiasis is not only a rare but also a difficult to diagnose parasitic disease. The symptoms are not specific and are often severe and abrupt; therefore, patients are sometimes diagnosed as having surgical abdomen. The clinical imaging findings are remarkable, including ascites, enteritis, ileus, eosinophilic granuloma and sometimes perforation. We experienced a case of intestinal anisakiasis diagnosed on the basis of the Anisakis-specific immunoglobulin A level from paired sera and treated successfully with conservative therapy, although ileum perforation was complicated by a 50-mm abscess. Even the large abscess could be treated without drainage in thiscase.

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“…FAD012 has a chemical structure where a methyl group is substituted for the methoxy group in the aromatic ring of FA, and FAD012 is more highly fat-soluble and poorly soluble in water than FA, so FAD012 presumably has drawbacks limiting its full efficacy. Our research group has already succeeded in synthesizing FA derivatives other than FAD012 and is finding pharmacological effects on cerebral circulation . Among them, FAD012 is a compound that is of interest for its pharmacological effects, but in view of its administration to animals, its solubility is poor; then, it is thought that a pharmaceutical approach is necessary.…”

Section: Introductionmentioning

confidence: 99%

Improvement of the Solubility and Evaluation of the Physical Properties of an Inclusion Complex Formed by a New Ferulic Acid Derivative and γ-Cyclodextrin

et al. 2020

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Ferulic acid derivative 012 (FAD012) is a ferulic acid (FA) derivative. The current study prepared a solid dispersion of FAD012 and γ-cyclodextrin (γCD) and ground it using a threedimensional ball mill (3DGM) to prepare an inclusion complex. This study also assessed the physicochemical properties such as solubility of that complex. A Job's plot indicated that FAD012 and γCD formed an inclusion complex at a molar ratio of 1:1. Phase solubility diagrams revealed that FAD012 produced a B S diagram. According to PXRD, FAD012 produced a diffraction peak at 2θ = 7.0°and γCD produced a diffraction peak at 2θ = 9.1°. Those two peaks were not produced by the 3DGM, but new peaks (2θ = 7.3 and 16.5°) were evident. DSC patterns revealed an endothermic peak due to the melting of FAD012 at 190 °C, but no endothermic peaks were evident with the 3DGM. NIR spectra of the 3DGM indicated that the methyl group of FAD012 produced a higher peak and that the OH groups of γCD produced a higher peak. 1 H-1 H ROESY NMR spectra (D 2 O) revealed cross peaks for protons of the methyl group of FAD012 and a proton (H-3) in the cavity of γCD, so FAD012 presumably interacts with the wide opening of the γCD torus. A solubility test (25 °C) indicated that solubility improved about 5-fold for the 3DGM in comparison to the solubility of FAD012 alone (about 140 μg/mL). Based on these findings, an FAD012/γCD complex was formed by cogrinding, and its solubility improved. These observations are expected to expand the usefulness of cogrinding of FAD012 with γCD using a 3D ball mill.

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Gastric Anisakiasis

Cited by 5 publications

References 4 publications

The Influence of Contracaecum larvae (Nematoda, Anisakidae) Parasitism on the Population of Prussian carp (Carassius gibelio) in Lake Sakadaš, Croatia

The Influence of Contracaecum larvae (Nematoda, Anisakidae) Parasitism on the Population of Prussian carp (Carassius gibelio) in Lake Sakadaš, Croatia

Fifty-millimeter abscess in the ileum caused by perforation from anisakiasis successfully treated with conservative therapy without drainage

Improvement of the Solubility and Evaluation of the Physical Properties of an Inclusion Complex Formed by a New Ferulic Acid Derivative and γ-Cyclodextrin

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