Gastric calcifying fibrous tumor mimicking GI stromal tumor

Okoronkwo, N. O.; Ghavimi, Shima; Peters, Stephen R.; Ahlawat, Sushil

doi:10.1016/j.gie.2018.04.003

Cited by 6 publications

(5 citation statements)

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“…No randomized controlled trial was included in the review. Finally, 30 full-text articles [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ] were included ( Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…EUS–FNA may be considered in GIST, especially for large ones, but it is not the standard management strategy. Two patients received FNA, but both failed to diagnose CFT [ 5 , 20 ] because it might have provided a small sample for diagnosis. Therefore, we do not suggest performing FNA in suspected CFT.…”

Section: Discussionmentioning

confidence: 99%

“…It is found as a solitary tumor or multiple lesions. The stomach seems to be the most common location of CFT [ 5 ]. The treatment of gastric CFT is simple; excision of the tumor is the choice of treatment with excellent prognosis [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…The stomach seems to be the most common location of CFT [ 5 ]. The treatment of gastric CFT is simple; excision of the tumor is the choice of treatment with excellent prognosis [ 5 ]. However, gastric CFTs are under-recognized because gastroenterologists, surgeons, and pathologists are unfamiliar with them.…”

Section: Introductionmentioning

confidence: 99%

“…Gastric CFTs could be treated with local incision or endoscopic submucosal dissection (ESD). Many cases have undergone open surgery, such as wedge resection or gastrotomy [ 5 ]. The characteristics of gastric CFT seem to be different from GIST.…”

Section: Introductionmentioning

confidence: 99%

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Gastric Calcifying Fibrous Tumor: An Easy Misdiagnosis as Gastrointestinal Stromal Tumor–A Systemic Review

et al. 2020

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Background and Objectives: Calcifying fibrous tumor (CFT) in the stomach is extremely rare and is easily misdiagnosed as a gastrointestinal stromal tumor (GIST). This study aims to determine the best method to differentiate between gastric CFT and GIST after a systemic review and meta-analysis. Materials and Methods: A systematic search of articles using electronic databases (MEDLINE, EMBASE, and LILACS) was conducted and resulted in 162 articles with 272 CFT cases published from January 1988 to September 2019. Results: Of these cases, 272 patients, 60 patients with gastric CFT (32 men and 28 women, mean age 49.2 years) were analyzed. The mean tumor size was 2.4 cm in patients with gastric CFT. Both endoscopic ultrasound (EUS) and computed tomography (CT) findings revealed well-defined (100% vs. 77.8%), heterogeneous (100% vs. 77.8%), iso-hypoechoic (71.4% vs. 33.3%), and calcified (85.7% vs. 77.8%) lesions, respectively. The majority of patients (53.3%) were symptomatic, with the most common symptom being abdominal discomfort (55.6%). None of the patients with gastric CFT showed recurrence after treatment, and most patients received nonendoscopic treatment (56%, n = 28/50). Both age and tumor size were statistically significant in patients with gastric CFT than GIST (49.2 vs. 65.0 years and 2.4 vs. 6.0 cm; both p < 0.001). The ratio of children among patients with CFT (5%) and GIST (0.05%) was also significantly different (p = 0.037). The calcification rates of gastric CFT had significantly higher calcification rates than GIST on images of EUS and CT (85.7% vs. 3.6% and 77.8% vs. 3.6%; both p < 0.001). Conclusions: Compared with patients with GIST, patients with gastric CFT were younger, had smaller tumor size, and were symptomatic. Furthermore, gastric CFT was well-defined, heterogeneous in the third layer, and had high calcification rates on the images.

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