Gastric cancer detection based on blood plasma surface-enhanced Raman spectroscopy excited by polarized laser light

Feng, Shouhua; Chen, Rong; Lin, Juqiang; Pan, Jianji; Wu, Yanan; Li, Yongzeng; Chen, Jiesi; Zeng, Haishan

doi:10.1016/j.bios.2010.12.020

Cited by 199 publications

(145 citation statements)

References 39 publications

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“…Furthermore, NPC is located near to the oral cavity, where metabolites, including DNA, RNA or proteins, may be drained to the saliva. Feng et al reported results similar to the findings demonstrated in the present study (18,39).…”

Section: Discussionsupporting

confidence: 92%

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Non-invasive detection of nasopharyngeal carcinoma using saliva surface-enhanced Raman spectroscopy

Qiu

Huang

et al. 2015

Oncology Letters

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Abstract. The present study evaluated the use of saliva surface-enhanced Raman spectroscopy (SERS) for the detection of non-invasive nasopharyngeal carcinoma (NPC). SERS measurements were taken from 62 saliva samples, of which 32 were from NPC patients and 30 from healthy volunteers. Notable biochemical Raman bands in the SERS spectra were tentatively assigned to various saliva components. The saliva SERS spectra obtained from the NPC patients and the healthy volunteers were also analyzed by multivariate statistical techniques based on principal component analysis and linear discriminant analysis (PCA-LDA). Significant differences were observed between the saliva SERS spectral intensities for NPC patients and healthy volunteers, particularly at 447, 496, 635, 729, 1134, 1270 and 1448 cm -1 , which primarily contained signals associated with proteins, nucleic acids, fatty acids, glycogen and collagen. The classification results based on the PCA-LDA method provided a relatively high diagnostic sensitivity of 86.7%, specificity of 81.3% and diagnostic accuracy of 83.9% for NPC identification. The results from the present study demonstrate that saliva SERS analysis used in conjunction with PCA-LDA diagnostic algorithms possesses a promising clinical application for the non-invasive detection of NPC.

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Section: Discussionsupporting

confidence: 92%

“…Therefore, in the present study, the SERS band at 1,448 cm -1 , which originates from the CH 2 bending mode of collagen, demonstrated an increased signal in NPC patient saliva compared with the saliva of healthy volunteers. This peak was also observed in other studies (18,39).…”

Section: Discussionsupporting

confidence: 89%

Non-invasive detection of nasopharyngeal carcinoma using saliva surface-enhanced Raman spectroscopy

Qiu

Huang

et al. 2015

Oncology Letters

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“…Reported studies applied to blood serum [77] for the detection of gastric [78,79], colorectal [80], pancreatic [81] and naso-pharyngeal cancers [82] highlight the interest and potential of such approaches. However, the use of nano-particles or appropriate metallic based substrates [83] is required, and while the approach is promising, reproducibility in the data collected remains a challenge [84].…”

Section: Discussionmentioning

confidence: 99%

Improved protocols for vibrational spectroscopic analysis of body fluids

Bonnier¹,

Petitjean

Baker

et al. 2013

Journal of Biophotonics

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The applications of vibrational spectroscopy to the examination of human blood serum are explored. Although FTIR spectra can be recorded in aqueous solutions at (gelatin) concentrations as low as 100 mg/L, the high-wavenumber region remains obscured by water absorption. Using Raman spectroscopy, high quality spectra of gelatine solutions as low as 10 mg/L can be achieved, also covering the high-wavenumber regions. In human serum, spectral profiles are weak and partially obscured by water features. Dried deposits are shown to be physically and chemically inhomogeneous resulting in reduced measurement reproducibility. Concentration of the serum using commercially available centrifugal filter devices results in an improvement in the spectral intensity and quality. Additionally, in Raman spectroscopy, reduced background and significantly enhanced signal collection is achievable by measurement in an inverted geometry. The improved protocols for spectroscopic measurement of human serum are applicable to a range of bodily fluids and should accelerate potential clinical applications

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“…Feng et al [89] exploited different polarity laser light and demonstrated that left-handed circularly polarized laser excitation has great promise of becoming a clinically useful diagnostic tool for non-invasive gastric cancer detection. Tang et al [90] introduced gold nanoparticles into live human osteosarcoma cells by endocytosis and adding them to the growth medium.…”

Section: Detection Of Other Malignanciesmentioning

confidence: 99%

Application of nanoparticles in cancer detection by Raman scattering based techniques

Ravanshad

Zadeh

Amani

et al. 2017

Nano Reviews & Experiments

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In vitro detection technique Raman spectroscopy (Rs), in one number times another Rs based expert ways of art and so on, are useful instruments for cancer discovery. top gave greater value to Raman spectroscopy sers is a relatively new careful way for in vitro and in vivo discovery that takes away bad points of simple Raman spectroscopy (Rs). Raman spectroscopy (RS) and in particular, multiple RS-based techniques are useful for cancer detection. Surface enhanced Raman spectroscopy (SERS) is a relatively new method for both in vitro and in vivo detection, which eliminates the drawbacks of simple RS. Using nanoparticles has elevated the sensitivity and specificity of SERS. SERS has the potential to increase sensitivity, specificity and spatial resolution in cancer detection, especially in cooperation with other diagnostic imaging tools such as magnetic resonance imaging (MRI) and PET-scan polyethylene terephthalate. Developing a hand held instrument for detecting cancer or other illnesses may also be feasible by using SERS. Frequently, novel nanoparticles are used in SERS. With a focus on nanoparticle utilization, we review the benefits of RS in cancer detection and related biomarkers. With a focus on nanoparticles utilizations, the benefits of RS in cancer detection and related biomarkers were reviewed. In addition, Raman applications to detect some of prevalent were discussed. Also more investigated cancers such as breast and colorectal cancer, multiple nanostructures and their possible special biomarkers, especially as SERS nano-tag have been reviewed. The main purpose of this article is introducing of most popular nanotechnological approaches in cancer detection by using Raman techniques. Moreover, have been caught up on detection and reviewed some of the most prevalent and also more investigated cancers such as breast, colorectal cancer, multiple intriguing nanostructures, especially as SERS nano-tag, special cancer biomarkers and related approaches. The main purpose of this article is to introduce the most popular nanotechnological approaches in cancer detection by using Raman techniques.

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Gastric cancer detection based on blood plasma surface-enhanced Raman spectroscopy excited by polarized laser light

Cited by 199 publications

References 39 publications

Non-invasive detection of nasopharyngeal carcinoma using saliva surface-enhanced Raman spectroscopy

Non-invasive detection of nasopharyngeal carcinoma using saliva surface-enhanced Raman spectroscopy

Improved protocols for vibrational spectroscopic analysis of body fluids

Application of nanoparticles in cancer detection by Raman scattering based techniques

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