Gastric carcinoma: Insights into risk factors, methods of diagnosis, possible lines of management, and the role of primary care

Marghalani, Aliyah M.; Salman, Thekra O Bin; Faqeeh, Fawaz J; Asiri, Mohammed K; Kabel, Ahmed M.

doi:10.4103/jfmpc.jfmpc_527_20

Cited by 23 publications

(13 citation statements)

References 42 publications

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“…Pseudomonas aeruginosa is a common multidrug-resistant pathogen, characterized by its capsule, Gram-negative nature, and aerobic or facultatively anaerobic growth, causing diseases in plants and animals, including humans ( Diggle and Whiteley, 2020 ). Helicobacter pylori is a Gram-negative, flagellated spiral bacterium, classified as a class I carcinogen, responsible for approximately 89% of gastric cancer cases and associated with 5.5% of cancer cases worldwide ( Violeta Filip et al, 2018 ; de Brito et al, 2019 ; Marghalani et al, 2020 ). In general, hosts within the same clustering branch are relatively homogeneous.…”

Section: Resultsmentioning

confidence: 99%

Identification and classification of the genomes of novel microviruses in poultry slaughterhouse

Xie,

Lin,

Sun

et al. 2024

Front. Microbiol.

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Microviridae is a family of phages with circular ssDNA genomes and they are widely found in various environments and organisms. In this study, virome techniques were employed to explore potential members of Microviridae in a poultry slaughterhouse, leading to the identification of 98 novel and complete microvirus genomes. Using a similarity clustering network classification approach, these viruses were found to belong to at least 6 new subfamilies within Microviridae and 3 higher-level taxonomic units. Genome size, GC content and genome structure of these new taxa showed evident regularities, validating the rationality of our classification method. Our method can divide microviruses into about 45 additional detailed clusters, which may serve as a new standard for classifying Microviridae members. Furthermore, by addressing the scarcity of host information for microviruses, the current study significantly broadened their host range and discovered over 20 possible new hosts, including important pathogenic bacteria such as Helicobacter pylori and Vibrio cholerae, as well as different taxa demonstrated different host specificities. The findings of this study effectively expand the diversity of the Microviridae family, providing new insights for their classification and identification. Additionally, it offers a novel perspective for monitoring and controlling pathogenic microorganisms in poultry slaughterhouse environments.

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Section: Resultsmentioning

confidence: 99%

Identification and classification of the genomes of novel microviruses in poultry slaughterhouse

Xie,

Lin,

Sun

et al. 2024

Front. Microbiol.

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show abstract

“…Pseudomonas aeruginosa is a common multidrug-resistant pathogen, characterized by its capsule, Gram-negative nature, and aerobic or facultatively anaerobic growth, causing diseases in plants and animals, including humans (48). Helicobacter pylori is a Gram-negative, flagellated spiral bacterium, classified as a class I carcinogen, responsible for approximately 89% of gastric cancer cases and associated with 5.5% of cancer cases worldwide (49)(50)(51). In general, hosts within the same clustering branch are relatively homogeneous.…”

Section: Phylogenetic Analysis Based On Cap Sequencesmentioning

confidence: 99%

Identification and classification of the genomes of novel Microviruses in poultry slaughterhouse

Xie,

Lin,

Zhu

et al. 2024

Preprint

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Microviridae is a family of phages with circular ssDNA genomes that are widely found in various environments and organisms. In this study, Virome techniques were employed to explore potential members of Microviridae in poultry slaughterhouse, leading to the identification of 98 novel and complete microvirus genomes. Using a similarity clustering network classification approach, these viruses were found to belong to at least 6 new subfamilies within Microviridae and 3 higher-level taxonomic units. Analysis of their genomes found that the genome size, GC content and genomic structure of these new taxa showed obvious regularities, validating the rationality of our classification method. Compared with the 19 families classified by previous researchers for microviruses dataset, our method can divide microviruses into about 45 more detailed clusters, which may serve as a new standard for classifying Microviridae members. Furthermore, addressing the scarcity of host information for microviruses, this study significantly broadened their host range and discovered over 20 possible new hosts, including important pathogenic bacteria such as Helicobacter pylori and Vibrio cholerae, as well as different taxa demonstrated distinct host specificity. The findings of this study effectively expand the diversity of the Microviridae, providing new insights for their classification and identification. Additionally, it offers a fresh perspective for monitoring and controlling pathogenic microorganisms in poultry slaughterhouse environments.

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“…In spite of the continuous improvement in the diagnosis and medical treatments of GC, surgical treatment remains its standard treatment strategy ( Sitarz et al, 2018 ). However, surgical treatment is still clinically limited in GC patients, because most of them are diagnosed at an advanced stage ( Marghalani et al, 2020 ). In fact, chemotherapy is still an essential mean for the treatment of GC ( Wagner et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

MFAP2 enhances cisplatin resistance in gastric cancer cells by regulating autophagy

Meng

Zhang

2023

PeerJ

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Background Cisplatin (CDDP) is of importance in cancer treatment and widely used in advanced gastric cancer (GC). However, its clinical usage is limited due to its resistance, and the regulatory mechanism of CDDP resistance in GC has not yet been fully elucidated. In this study, we first conducted a comprehensive study to investigate the role of MFAP2 through bioinformatics analysis. Methods The Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases were applied to downloadgene expression data and clinicopathologic data, and the differentially expressed genes (DEGs) were further analyzed. Then, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis and survival analysis were conducted. Furthermore, according to the clinicopathological characteristics of TCGA, clinical correlation analysis was conducted, and a receiver operating characteristic curve (ROC) was plotted. Results We revealed that FAP, INHBA and MFAP2 were good diagnostic factors of GC. However, the mechanism of MFAP2 in GC remains elusive, especially in the aspect of chemotherapy resistance. We developed the CDDP-resistant cell line, and found that MFAP2 was upregulated in CDDP-resistant cells, and MFAP2-knockdown improved CDDP sensitivity. Finally, we found that MFAP2 enhanced CDDP resistance by inducing autophagy in drug-resistant cell lines. Conclusions The above results suggested that MFAP2 could affect the chemotherapy resistance by altering the level of autophagy in GC patients as a potential therapeutic target.

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Gastric carcinoma: Insights into risk factors, methods of diagnosis, possible lines of management, and the role of primary care

Cited by 23 publications

References 42 publications

Identification and classification of the genomes of novel microviruses in poultry slaughterhouse

Identification and classification of the genomes of novel microviruses in poultry slaughterhouse

Identification and classification of the genomes of novel Microviruses in poultry slaughterhouse

MFAP2 enhances cisplatin resistance in gastric cancer cells by regulating autophagy

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