Gastric emptying rates of solid food in relation to body mass index: an ultrasonographic and scintigraphic study

Brogna, A.; Ferrara, Rosario; Bucceri, A.; Crea, Filippo; Natoli, G; Leocata, Vincenzo

doi:10.1016/s0720-048x(97)00081-8

Cited by 19 publications

(12 citation statements)

References 15 publications

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“…However, in neither of these studies, a relation between the delay in gastric emptying and weight loss could be demonstrated. We also cannot confirm the existence of a relationship between BMI and gastric emptying as reported by others [18,19,23].…”

Section: Discussioncontrasting

confidence: 84%

Weight Loss After Laparoscopic Adjustable Gastric Banding is not Caused by Altered Gastric Emptying

Jong¹,

Ramshorst

Gooszen

et al. 2008

OBES SURG

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Section: Discussioncontrasting

confidence: 84%

Weight Loss After Laparoscopic Adjustable Gastric Banding is not Caused by Altered Gastric Emptying

Jong¹,

Ramshorst

Gooszen

et al. 2008

OBES SURG

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“…Meanwhile, low BMI was not a significant risk factor with delayed gastric emptying among the female patients. Brogna et al [22] showed an inverse linear correlation between BMI and gastric emptying rate in healthy subjects. Interestingly, Xu et al [23] reported that underweight and overweight were statistically significant risk factors among patients with the severity of acid regurgitation symptoms.…”

Section: Discussionmentioning

confidence: 99%

Gender Difference of Gastric Emptying in Healthy Volunteers and Patients with Functional Dyspepsia

Mori¹,

Suzuki

Matsuzaki³

et al. 2017

Digestion

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Background and Aim: Delayed gastric emptying is one of the reasons why functional dyspepsia (FD) occurs. The ¹³C-acetate breath test is widely used to evaluate gastric emptying. Nevertheless, the standard value of ¹³C-acetate breath test has not taken into account the gender difference of gastric emptying among healthy individuals. The main aim of this study was to readjust the standard value of ¹³C-acetate breath test in the light of gender differences. In addition, we clarified the prevalence and clinical characteristics of delayed gastric emptying in patients with FD using the modified standard values of ¹³C-acetate breath test. Methods: Fifty-two healthy individuals and 126 patients with patients with FD were enrolled. Gastric emptying was evaluated by the ¹³C-acetate breath test. The cut-off points of T_max for the diagnosis of delayed gastric emptying were determined on the basis of results from healthy individuals making a distinction of genders. Gastroesophageal reflux symptoms, dyspeptic symptoms, scores of anxiety and depression, age, body mass index (BMI), smoking and alcohol consumption were compared between the delayed gastric emptying group and the non-delayed gastric emptying group. Results: Since gastric emptying was delayed in healthy women compared with that in healthy men (T_max, 53.6 ± 19.3 vs. 42.7 ± 16.9 min, p = 0.04), we set the cut-off points of T_max at 60 min in men and at 75 min in women. In patients with FD, the prevalence of delayed gastric emptying was not different between men and women with the modified standard values of ¹³C-acetate breath test. (31.0 vs. 27.4%, p = 0.68). BMI was lower in the delayed gastric emptying group than in the non-delayed group among the male patients. Reflux symptoms were more severe in delayed gastric emptying group than in the non-delayed group among the female patients. Conclusion: The standard values of ¹³C-acetate breath test should be modified bearing the gender difference in mind. It provides us more appropriate information to understand the mechanisms of FD.

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“…Several physiologic factors that may modify gastric emptying include age [24], gender [25], and body mass index [26]. In addition, some pathological factors, such as Helicobacter pylori infection status [27] and hyperglycemia [28], have been regarded as possible determinants of gastric emptying.…”

Section: Discussionmentioning

confidence: 99%

Dual Effects of Rabeprazole on Solid-Phase Gastric Emptying Assessed by the <sup>13</sup>C-Octanoate Breath Test

Anjiki¹,

Sanaka²,

Kawakami³

2005

Digestion

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Background/Aims: Knowledge is limited regarding the effects of rabeprazole on gastric emptying. This randomized, open, crossover study was undertaken to investigate the effects. Methods: In 24 healthy volunteers (13 men and 11 women, aged 22–53 years), solid emptying was assessed twice using the ¹³C-octanoate breath test. On one occasion, the subjects received 20 mg rabeprazole for the preceding 2 days and 1 h before the test. On another occasion, they underwent no pretreatment. The time course of cumulative recovery of ¹³CO₂ in breath was fitted to z(t) = m(1 – e^–kt)^β^–1, and regression constants of k and β were determined. The half ¹³CO₂ excretion time (t_½b) and the time of maximal excretion (t_max) were calculated. Under the crossover protocol, k and β can describe the emptying features more precisely; a larger (smaller) β indicates a slower (faster) emptying in the early phase, and a larger (smaller) k indicates a faster (slower) emptying in the later phase. Between the two occasions, k, β, t_½b, and t_max were compared. Results: Rabeprazole significantly decreased k and β, significantly prolonged t_½b, but t_max remained unchanged. Conclusion: Rabeprazole has dual effects on solid emptying: an initial acceleration with a subsequent deceleration, resulting in an overall delay.

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Gastric emptying rates of solid food in relation to body mass index: an ultrasonographic and scintigraphic study

Cited by 19 publications

References 15 publications

Weight Loss After Laparoscopic Adjustable Gastric Banding is not Caused by Altered Gastric Emptying

Weight Loss After Laparoscopic Adjustable Gastric Banding is not Caused by Altered Gastric Emptying

Gender Difference of Gastric Emptying in Healthy Volunteers and Patients with Functional Dyspepsia

Dual Effects of Rabeprazole on Solid-Phase Gastric Emptying Assessed by the <sup>13</sup>C-Octanoate Breath Test

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