Gastric H+, K+-ATPase inhibition by catechins

Murakami, Shigeru; Murata, Makoto; Otomo, Susumu

doi:10.1111/j.2042-7158.1992.tb03238.x

Cited by 44 publications

(26 citation statements)

References 18 publications

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“…In vitro, tea catechins can inhibit carbohydrate digestive enzymes, such as salivary a-amylase, intestinal sucrase, a-glucosidase, and gastric H + ,K + -ATPase [124][125][126]. Using a rat everted sac, Kobayashi et al [127] showed that green tea polyphenols, especially ECG and EGCG, inhibited the sodium-dependent GLUT (Na bit intestinal brush-border membrane vesicles to demonstrate that 1 mM of ECG or EGCG reduced the glucose uptake by 53 and 35%, respectively, whereas no effect was observed after C and EGC treatments.…”

Section: Modulation Of Carbohydrate-related Enzymes and Transportersmentioning

confidence: 99%

Tea, obesity, and diabetes

Kao¹,

Chang

Lee

et al. 2006

Molecular Nutrition Food Res

294

204

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Tea has been found to possess widespread biological functions based on a variety of laboratory data. The effects of tea on obesity and diabetes have received increasing attention. This paper reviews the evidence for the connections among tea catechins, and obesity and diabetes. Tea catechins, especially (-)-epigallocatechin gallate (EGCG), appear to have antiobesity and antidiabetic effects. While few epidemiological and clinical studies show the health benefits of EGCG on obesity and diabetes, the mechanisms of its actions are emerging based on the various laboratory data. These mechanisms may be related to certain pathways, such as through the modulations of energy balance, endocrine systems, food intake, lipid and carbohydrate metabolism, the redox status, and activities of different types of cells (i. e., fat, liver, muscle, and beta-pancreatic cells). Because the EGCG receptor, the so-called 67-kDa laminin receptor (LR), has been discovered with colocalization of other types of LR and cytoskeleton in both cancer cells and normal cells, this may explain that EGCG possesses numerous actions. The mechanistic results of this review may possibly be utilized in the treatment of obesity, diabetes, and other related diseases using tea- and EGCG-based folk medicines.

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Section: Modulation Of Carbohydrate-related Enzymes and Transportersmentioning

confidence: 99%

Tea, obesity, and diabetes

Kao¹,

Chang

Lee

et al. 2006

Molecular Nutrition Food Res

294

204

View full text Add to dashboard Cite

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“…Several recent reviews have highlighted this activity. Detailed studies [62][63][64] have revealed that quercetin exerted a dose-dependent inhibition of growth and colony formation. The flavonoids, kaempferol, catechin, toxifolin and fisetin, also suppressed cell growth 65,66 .…”

Section: Antineoplastic Activitymentioning

confidence: 99%

Flavonoids as Nutraceuticals: A Review

Tapas¹,

Sakarkar²,

Kakde³

2008

Trop. J. Pharm Res

674

380

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“…The intensity of inhibitor activity parallels the number of phenolic hydroxy groups in the molecule. These findings suggest that the anti-secretory and anti-ulcerogenic effects of catechins are due to their inhibitory activity on gastric H+, K(+)-ATPase (14).…”

Section: Discussionmentioning

confidence: 76%

The effect of epigallocatechin gallate on intestinal motility in mice

Ceregrzyn

Kuwahara

2003

Environ Health Prev Med

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Objectives: The epigallocatechin-3-gallate (EGCg) that is present in human diet originates mainly from tea leaves. Catechins have a number of possible application as medicines, however, there is no consistent evidence showing their influence on the gastrointestinal tract. Thus, the aim of the present study was to investigate the effect of EGCg on the motility of the murine isolated intestine.Methods: Segments of jejunum submerged in Krebs buffer were exposed to EGCg and the response was recorded under isometric conditions.Results: EGCg induced a dose-dependent inhibition of spontaneous activity in the jejunum. EGCg induced a decrease in the amplitude and frequency of jejunal contractions. Moreover, the rythmicity of spontaneous activity was altered in the presence of EGCg. A significant effect of EGCg was observed in the presence of 10 −4 M. The effect of EGCg was in part inhibited by pretreatment with methylene blue (guanylate cyclase inhibitor), while tetrodotoxin, (sodium channel blocker), L-nitro arginine methyl ester (nitric oxide synthase inhibitor), and N-ethylmaleimide (adenylate cyclase inhibitor) showed no effect.Conclusions: The results of the present study suggest that EGCg inhibits the motility of the jejunum by direct action on smooth muscle cells where a guanylate cyclase-dependent mechanism may be partly involved.

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Gastric H+, K+-ATPase inhibition by catechins

Cited by 44 publications

References 18 publications

Tea, obesity, and diabetes

Tea, obesity, and diabetes

Flavonoids as Nutraceuticals: A Review

The effect of epigallocatechin gallate on intestinal motility in mice

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