Gastric side effects and the stomach dosimetric analysis in left-sided breast cancer radiotherapy in free-breathing and deep inspiration breath-hold technique

Abstract

Background Adjuvant radiotherapy following surgery reduces the local recurrence and improves the prognosis. However, a considerable part of patients developed digestive reaction in daily treatment. In order to explore the correlation between breast radiotherapy and gastric toxicity, we investigated the clinic symptoms and stomach dose during DIBH or FB mode while left-sided breast cancer patients (LSBCP) receiving radiotherapy. Methods In the study, 124 LSBCP received adjuvant radiotherapy after surgery at our department were analyzed clinical characteristics and enquired about gastrointestinal side effects after treatment. Moreover, dosimetric parameters were assessed. Results There was no statistically significant difference between the two groups in age, T staging, N staging, hormone receptors, human epidermal receptor-2 (HER2), surgical methods, fractionated regimen, and chemotherapy conditions. However, larger stomach volumes and higher fractionated dose (Dmax/F) were associated with a statistically significantly greater risk for acute radiotherapy toxicity. In addition, the use of the DIBH gating technique (FB/DIBH) reduced the incidence of digestive reactions. Conclusion In order to cut down gastric side effects after breast radiotherapy, large meals should be avoided before treatment. DIBH treatment should be implemented in centers where conditions are satisfied to reduce radiotherapy side effects. Furthermore, dose limitation in stomach should be considered when the radiotherapy plan was formulated, especially for the patients treated with hypofractionated radiotherapy.

needs of patients receiving brain radiotherapy at Fayoum oncology center

“…Also, in accordance with the present studyPruijssen, et al, (2022) reported that in patients receiving head and neck radiotherapy fatigue was highly prevalent: 51.7% experienced severe fatigue (subjective fatigue score ≥ 35). On the same way, the study ofYang, et al, (2022) reported that, of all the patients receiving radiotherapy, 12.1% (15/124) patients developed gastric symptoms including loss of appetite and nausea.In the same way, Iglseder, et al, (2022) reported that, 20% of the patients receiving radiotherapy experienced acute Neurological side effects as headache due to increased intracranial pressure. This finding in agreement with the results of the study done bySourati, et al, (2017) about Acute side effects of radiation therapy in cancer patients revealed that the most frequently reported side effects were fatigue, headache, anorexia or nausea, and vomiting.…”

SGRT-based DIBH radiotherapy practice for right breast cancer combined with RNI: A retrospective study on dosimetry and treatment accuracy

“…Colossal amounts of studies have shown that amid left breast cancer radiotherapy, DIBH technology can separate the heart from mammary gland position, so as to signi cantly shrink the high dose volume and mean dose of the heart, and reduce heart disease risks associated [18][19][20] . Meanwhile, coupled with DIBH technology, it can also increase the lung volume, reduce the lung tissue density, which lowers the irradiation dose in the lung 13 , and slump the irradiation dose of the contralateral breast, stomach and liver to varying degrees 21,22 . Although DIBH technique is widely used in left-sided breast cancer, there are few reports on the clinical application of DIBH technique in right-sided breast cancer.…”

64-Slice Spiral Computerized Tomography under Algebraic Reconstruction Algorithm in the Surgical Treatment of Acquired Immune Deficiency Syndrome Complicated with Gastric Cancer

“…In the equation, p i represented the sampling value obtained by compressed sensing with the number of n. R was the observation base composed of a set of observation vectors (ϕ i ) n i�1 . e key to construct a signal was to find the sparse representation of the signal in a certain variation domain ∀, which could be solved by means of the L0 norm optimization in (2). min ‖∀ε‖ 0 zt, p � ϕ ε.…”

“…e ability to resist infection and tumor defense in patients with acquired immune de ciency syndrome (AIDS) decreased due to immunode ciency. It is very easy to complicate with various tumors, and the probability of su ering from tumors is about 50 times of the normal population [1][2][3].…”