Gastric ulcers differ from duodenal ulcers evaluation of basal acid output

Abstract

Patients with pyloric channel and prepyloric gastric ulcers are often considered to have an ulcer diathesis similar to patients with duodenal ulcers, while patients with more proximal gastric ulcers (ie, fundus, body, antrum) are excluded. To evaluate possible differences in basal acid outputs with regard to gastric ulcer location, basal acid outputs were determined by nasogastric suction in 80 patients with endoscopically documented benign active gastric ulcers. The results were compared to 65 normal subjects and 155 patients with endoscopically documented duodenal ulcers. There were no significant differences in basal acid outputs among the 80 patients with gastric ulcers with regard to location (ie, fundus-body, antrum, prepyloric, channel), and no significant differences compared to the 65 normal subjects. However, basal acid output for the 155 patients with duodenal ulcers was significantly different from the 80 patients with gastric ulcers (P < 0.05) and the 65 normal subjects (P < 0.05). Basal acid outputs tended to be higher and there was more gastric acid hypersecretion when gastric ulcers were located near the pylorus. However, irrespective of gastric ulcer location, basal acid outputs were higher in patients with duodenal ulcers. Seventy-one of the 80 patients with gastric ulcers were treated for eight weeks with standard doses of antisecretory medications, and endoscopic healing or nonhealing was documented. In 60 patients their gastric ulcers completely healed, while 11 patients had nonhealed gastric ulcers. There were no significant differences between the two groups with regard to gender, mean age, or basal acid output.(ABSTRACT TRUNCATED AT 250 WORDS)

Gastrin release and gastric acid secretion in the rat infected with either Helicobacter felis or Helicobacter heilmannii

“…Duodenal ulcer patients that are infected with H. pylori also experience a rise in acid output, which is probably the result of previous h y p e r g a~t r i n a e m i a .~~,~~*~~,~~-~~>~~~~ Gastric ulcer patients usually have a normal or slightly decreased level of acid output, which differs depending on the location of the ulcer. 42 If the gastric ulcer is closer to the pylorus, basal acid output tends to be higher. Very few studies have shown that H. pybri influences gastric acid in asymptomatic patients.…”