Gastroduodenal Mucosal Injury Profile in Long-Term Low-Dose Aspirin Users and Its Influencing Factors

Abstract

Background: Low-dose aspirin is the most common drug used for prevention of cardiovascular and cerebrovascular events. Long-term aspirin therapy can induce gastroduodenal mucosal injury, even in a very low dose (10 mg daily). The frequency of gastroduodenal injuries among long-term low-dose aspirin users in (OR = 3.3;). However, proton pump inhibitor (PPI) decreased the risk of mucosal injury (OR = 0,2; 95% CI: 0,60

Effects of Hyperbaric Oxygen Therapy on the Expression of FGF, MMP-9 and Occludin in the Repair of Gastric Mucosal Erosions

“…8 Based on studies with long-term LDA therapy, it was found that gastroduodenal mucosal damage occurred in patients (51.6%). 9 The side effects of NSAIDs therapy can be even more severe, namely the occurrence of gastrointestinal bleeding. [10][11][12][13] Pharmacognosy Journal, Vol 14, Issue 3, May-June, 2022 COX-1 is inhibited it results in tissue ischemia.…”