Gastroenteritis aguda nosocomial e infección asintomática por rotavirus y astrovirus en niños hospitalizados

Riechmann, Enriqueta Román; Cal, Isabel Wilhelmi de; Pascual, MaL Cilleruelo; Calvo, Cristina; García, MaL García; Sánchez-Fauquier, Alicia

doi:10.1157/13058903

Cited by 14 publications

(13 citation statements)

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“…RotaTeq also contains P[8], a predominant genotype and the most common P-type associated with human RV strains in Europe and worldwide. Studies suggest vaccines containing the serotype P[8] may protect against other G-serotypes, such as G9, which was confirmed for RotaTeq in the REST study. G1, G2, G3, G4 and G9 serotypes account for 98% of RVGE cases in Spain[21].…”

Section: Methodsmentioning

confidence: 65%

“…RVGE is a major reason for hospitalisation, and it is responsible for an important number of nosocomial infections in paediatric wards, which increase the medical resources required for treating these children with RVGE[7,8]. According to Gil et al[3], the annual incidence of hospital admissions attributable to rotavirus is 1.0 per 1000 children ≤5 years, although it can be as high as 2.5 per 1000 children ≤5 years during the winter season.…”

Section: Introductionmentioning

confidence: 99%

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Burden of paediatric Rotavirus Gastroenteritis (RVGE) and potential benefits of a universal Rotavirus vaccination programme with a pentavalent vaccine in Spain

Díez-Domingo¹,

Suriñach

Alcalde

et al. 2010

BMC Public Health

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BackgroundRotavirus is the most common cause of gastroenteritis in young children worldwide. The aim of the study was to assess the health outcomes and the economic impact of a universal rotavirus vaccination programme with RotaTeq, the pentavalent rotavirus vaccine, versus no vaccination programme in Spain.MethodsA birth cohort was followed up to the age of 5 using a cohort model. Epidemiological parameters were taken from the REVEAL study (a prospective epidemiological study conducted in Spain, 2004-2005) and from the literature. Direct and indirect costs were assessed from the national healthcare payer and societal perspectives by combining health care resource utilisation collected in REVEAL study and unit costs from official sources. RotaTeq per protocol efficacy data was taken from a large worldwide rotavirus clinical trial (70,000 children). Health outcomes included home care cases, General Practioner (GP)/Paediatrician, emergency department visits, hospitalisations and nosocomial infections.ResultsThe model estimates that the introduction of a universal rotavirus vaccination programme with RotaTeq (90% coverage rate) would reduce the rotavirus gastroenteritis (RVGE) burden by 75% in Spain; 53,692 home care cases, 35,187 GP/Paediatrician visits, 34,287 emergency department visits, 10,987 hospitalisations and 2,053 nosocomial infections would be avoided. The introduction of RotaTeq would avoid about 76% of RVGE-related costs from both perspectives: €22 million from the national health system perspective and €38 million from the societal perspective.ConclusionsA rotavirus vaccination programme with RotaTeq would reduce significantly the important medical and economic burden of RVGE in Spain.

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Section: Methodsmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Burden of paediatric Rotavirus Gastroenteritis (RVGE) and potential benefits of a universal Rotavirus vaccination programme with a pentavalent vaccine in Spain

Díez-Domingo¹,

Suriñach

Alcalde

et al. 2010

BMC Public Health

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“…Few studies in Spain have assessed the burden of nosocomial rotavirus infection, even though it is considered to be one of the principal hospital-acquired infections in young children [9,11-13]. We describe here the characteristics of hospitalizations associated with rotavirus infection in the autonomous region of Catalonia during the years 2003-2008.…”

Section: Introductionmentioning

confidence: 99%

Hospitalizations due to rotavirus gastroenteritis in Catalonia, Spain, 2003-2008

et al. 2011

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BackgroundRotavirus is the most common cause of severe gastroenteritis among young children in Spain and worldwide. We evaluated hospitalizations due to community and hospital-acquired rotavirus gastroenteritis (RVGE) and estimated related costs in children under 5 years old in Catalonia, Spain.ResultsWe analyzed hospital discharge data from the Catalan Health Services regarding hospital admissions coded as infectious gastroenteritis in children under 5 for the period 2003-2008. In order to estimate admission incidence, we used population estimates for each study year published by the Statistic Institut of Catalonia (Idescat). The costs associated with hospital admissions due to rotavirus diarrhea were estimated for the same years. A decision tree model was used to estimate the threshold cost of rotavirus vaccine to achieve cost savings from the healthcare system perspective in Catalonia. From 2003 through 2008, 10655 children under 5 years old were admitted with infectious gastroenteritis (IGE). Twenty-two percent of these admissions were coded as RVGE, yielding an estimated average annual incidence of 104 RVGE hospitalizations per 100000 children in Catalonia. Eighty seven percent of admissions for RVGE occurred during December through March. The mean hospital stay was 3.7 days, 0.6 days longer than for other IGE. An additional 892 cases of presumed nosocomial RVGE were detected, yielding an incidence of 2.5 cases per 1000 child admissions. Total rotavirus hospitalization costs due to community acquired RVGE for the years 2003 and 2008 were 431,593 and 809,224 €, respectively. According to the estimated incidence and hospitalization costs, immunization would result in health system cost savings if the cost of the vaccine was 1.93 € or less. At a vaccine cost of 187 € the incremental cost per hospitalization prevented is 195,388 € (CI 95% 159,300; 238,400).ConclusionsThe burden of hospitalizations attributable to rotavirus appeared to be lower in Catalonia than in other regions of Spain and Europe. The relatively low incidence of hospitalization due to rotavirus makes rotavirus vaccination less cost-effective in Catalonia than in other areas with higher rotavirus disease burden.

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“…De la misma manera, a pesar de no ser parte de los objetivos del estudio, no se obtuvo información sobre el inicio de los síntomas. Por ello, no pudimos determinar cuántos casos nosocomiales ocurrieron en este período, ya que la existencia de este tipo de infección ha sido descrita en diferentes trabajos publicados 11,12 .…”

Section: Discussionunclassified

Estudio retrospectivo de 10 años de la infección por rotavirus en la provincia de Castellón

Tellez-Castillo

Balaguer

Revuelta

et al. 2008

Anales de Pediatría

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Gastroenteritis aguda nosocomial e infección asintomática por rotavirus y astrovirus en niños hospitalizados

Cited by 14 publications

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Burden of paediatric Rotavirus Gastroenteritis (RVGE) and potential benefits of a universal Rotavirus vaccination programme with a pentavalent vaccine in Spain

Burden of paediatric Rotavirus Gastroenteritis (RVGE) and potential benefits of a universal Rotavirus vaccination programme with a pentavalent vaccine in Spain

Hospitalizations due to rotavirus gastroenteritis in Catalonia, Spain, 2003-2008

Estudio retrospectivo de 10 años de la infección por rotavirus en la provincia de Castellón

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