Gastroesophageal Reflux With Protein-Losing Enteropathy and Finger Clubbing

Herbst, John J.; Johnson, Dale G.; Oliveros, Miguel A.

doi:10.1001/archpedi.1976.02120120090017

Cited by 18 publications

(34 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…9 More severe inflammation may cause chronic blood loss with anemia, hematemesis, melena or hypoproteinemia. 10 Chronic inflammation may also result in replacement of distal esophageal mucosa with a metaplastic specialized epithelium known as Barrett's mucosa. 11 Pathophysiological factors implicated in the causation of GER include inappropriate relaxation of the lower esophageal sphincter, reduced lower esophageal sphincter length and pressure, intrathoracic location and abnormal smooth muscle function.…”

Section: Introductionmentioning

confidence: 99%

GERD or not GERD: the fussy infant

Bhatia

Parish

2009

J Perinatol

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

GERD or not GERD: the fussy infant

Bhatia

Parish

2009

J Perinatol

View full text Add to dashboard Cite

“…When esophagitis is treated with acid secretion inhibitors, both symptoms are resolved. [31][32][33] Other joint disorders associated with GER have been reported, showing remission after acid suppression. 34 The results of this study, with sensitivity of 91.7% and specificity of 87.5%, are similar to those reported by James and Ewer (89% sensitivity and 80% specificity).…”

Section: Resultsmentioning

confidence: 99%

pH nasofaríngeo e refluxo gastroesofágico em crianças com doença respiratória crônica

Junqueira

Penna²

2007

J. Pediatr. (Rio J.)

View full text Add to dashboard Cite

Objectives: The aim of this case-control study was to evaluate the nasopharyngeal pH (NasopH) in children with normal or abnormal pH-metry in two groups of patients: 1) children presenting gastroenterological symptoms; and 2) children with chronic respiratory symptoms. Methods:From February 2004 to January 2005, all consecutive patients referred for 24-hour pH-metry and in whom gastroesophageal reflux disease was suspected were enrolled in a prospective study. They were assigned to four groups: gastroenterological symptoms with normal (A) or abnormal (B) pH-metries (GG), and chronic respiratory symptoms with normal (C) or abnormal (D) pH-metries (RG). NasopH was measured for 5 minutes, before the 24-hour test was performed.Results: Thirty-eight pH-metry tests were included (20 in the RG and 18 in the GG). Abnormal pH-metry results were observed in 11 patients in the GG and in 12 in the RG. NasopH means were 6.3273 and 5.6917, respectively (p < 0.0001). Average nasopharyngeal pH was 5.6917 among the 12 RG patients with abnormal pH-metry results and 6.5000 among the remaining eight patients with normal test results (p = 0.0006). Analysis of the RG with a receiver operating characteristic (ROC) curve showed pH of 5.8 as cutoff point (sensitivity of 91.7% and specificity of 87.5%).The area below the ROC curve was 0.870. Conclusions:Nasopharyngeal pH is significantly lower among patients in the RG presenting abnormal pH-metry results. A 5.8 NasopH has good sensitivity and specificity and can be used as a screening test in patients with chronic respiratory diseases to select those for whom conventional 24-hour pH-metry is indicated.J Pediatr (Rio J). 2007;83(3):225-232: Gastroesophageal reflux/complications/diagnosis, child, evaluation studies, nasopharynx, esophageal pH monitoring.

show abstract

“…The association of hypoalbuminaemia and reflux oesophagitis was first described by Herbst et al 4 Fung et al reported that 27/121 patients requiring Nissen fundoplication for the correction of their gastro-oesophageal reflux had low serum albumin concentrations.' They found significant correlation between presence of hypoalbuminaemia, features of Barrett's oesophagus, and the severity of reflux.…”

Section: Discussionmentioning

confidence: 96%