Gastrointestinal Digestion and Absorption

Bhagavan, N.V.; Ha, Chung-Eun

doi:10.1016/b978-0-12-416687-5.00011-7

Cited by 5 publications

(5 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With the exception of four proteins for which no expression data was available, we found that all detected host proteins are present in pancreatic juice, small intestine, colon, rectum and stomach, with particularly high numbers expressed in human pancreatic juice, and the colon ( table 1 ). Pancreatic juice neutralizes stomach acid as it passes from the stomach into the small intestine, and contains multiple digestive enzymes [ 51 ]. The detection of proteins expressed in the stomach, pancreatic juice, and the small intestine was therefore consistent with a digestive proteome, while proteins expressed in the colon and rectum were expected in a faecal proteome and supported a host origin.…”

Section: Resultsmentioning

confidence: 99%

Palaeoproteomic analyses of dog palaeofaeces reveal a preserved dietary and host digestive proteome

et al. 2021

View full text Add to dashboard Cite

The domestic dog has inhabited the anthropogenic niche for at least 15 000 years, but despite their impact on human strategies, the lives of dogs and their interactions with humans have only recently become a subject of interest to archaeologists. In the Arctic, dogs rely exclusively on humans for food during the winter, and while stable isotope analyses have revealed dietary similarities at some sites, deciphering the details of provisioning strategies have been challenging. In this study, we apply zooarchaeology by mass spectrometry (ZooMS) and liquid chromatography tandem mass spectrometry to dog palaeofaeces to investigate protein preservation in this highly degradable material and obtain information about the diet of domestic dogs at the Nunalleq site, Alaska. We identify a suite of digestive and metabolic proteins from the host species, demonstrating the utility of this material as a novel and viable substrate for the recovery of gastrointestinal proteomes. The recovered proteins revealed that the Nunalleq dogs consumed a range of Pacific salmon species (coho, chum, chinook and sockeye) and that the consumed tissues derived from muscle and bone tissues as well as roe and guts. Overall, the study demonstrated the viability of permafrost-preserved palaeofaeces as a unique source of host and dietary proteomes.

show abstract

Section: Resultsmentioning

confidence: 99%

Palaeoproteomic analyses of dog palaeofaeces reveal a preserved dietary and host digestive proteome

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The gastric transit time may vary, but it is estimated in average to take around 1 to 2 h before the gastric content is released into the duodenum of the small intestine, which provides a neutral environment with a pH of around 6.5 (Marciani et al, 2001). In the duodenum, the dietary proteins are subjected to the endopeptidases trypsin, chymotrypsin and elastase, and the exopeptidases carboxypeptidase A and B, produced by the pancreas (Bhagavan & Ha, 2015). The brush border also plays an important role in the digestion of dietary proteins, where neutral endopeptidases are anchored into the apical side of the epithelial cells as integral membrane proteins with their active site projecting into the lumen.…”

Section: Gastrointestinal Protein Digestionmentioning

confidence: 99%

Intestinal protein uptake and IgE-mediated food allergy

Ballegaard¹,

Bøgh²

2023

Food Research International

View full text Add to dashboard Cite

“…The first step in proteins’ degradation occurs in the mouth [ 25 ]. Once the denaturized proteins reach the small intestine they are subjected to both endopeptidase and exopeptidase activity [ 26 ] in the epithelial brush border [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Dietary Intervention during Weaning and Development of Food Allergy: What Is the State of the Art?

Gravina,

Olivero,

Brindisi

et al. 2024

IJMS

View full text Add to dashboard Cite

Food allergy (FA) affects approximately 6–8% of children worldwide causing a significant impact on the quality of life of children and their families. In past years, the possible role of weaning in the development of FA has been studied. According to recent studies, this is still controversial and influenced by several factors, such as the type of food, the age at food introduction and family history. In this narrative review, we aimed to collect the most recent evidence about weaning and its role in FA development, organizing the gathered data based on both the type of study and the food. As shown in most of the studies included in this review, early food introduction did not show a potential protective role against FA development, and we conclude that further evidence is needed from future clinical trials.

show abstract

Gastrointestinal Digestion and Absorption

Cited by 5 publications

References 29 publications

Palaeoproteomic analyses of dog palaeofaeces reveal a preserved dietary and host digestive proteome

Palaeoproteomic analyses of dog palaeofaeces reveal a preserved dietary and host digestive proteome

Intestinal protein uptake and IgE-mediated food allergy

Dietary Intervention during Weaning and Development of Food Allergy: What Is the State of the Art?

Contact Info

Product

Resources

About