Gastrointestinal functionality in animal nutrition and health: New opportunities for sustainable animal production

Celi, Pietro; Cowieson, A. J.; Fru-Nji, F.; Steinert, Robert E.; Kluenter, Anna-Maria; Verlhac, Viviane

doi:10.1016/j.anifeedsci.2017.09.012

Cited by 308 publications

(262 citation statements)

References 119 publications

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“…Intestinal morphology, including villus height, crypt depth and the VH/CD ratio, is an important indicator of intestinal health, recovery and functionality and plays a P-values represent the main effect of the diet, the main effect of NE challenged, and the interaction between the dietary treatments and NE challenged P-values represent the main effect of the diet, the main effect of the NE challenge, and the interaction between the dietary treatments and NE challenge significant role in nutrient digestion and absorption [52].…”

Section: Discussionmentioning

confidence: 99%

Dietary encapsulated essential oils and organic acids mixture improves gut health in broiler chickens challenged with necrotic enteritis

Pham

Kan

Huang³

et al. 2020

J Animal Sci Biotechnol

105

101

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Background: The poultry industry is in need of effective antibiotic alternatives to control outbreaks of necrotic enteritis (NE) due to Clostridium perfringens. In the present study, we investigated the effects of dietary supplementation with a blend of encapsulated essential oils and organic acids (BLJ) on growth performance and gut health using a coinfection model of NE in broiler chickens. Methods: Two hundred and eighty-eight one-day-old male Arbor Acres broiler chicks were randomly assigned using a 2 × 2 factorial design into two groups fed either 0 or 500 mg/kg dietary BLJ and co-challenged (or not challenged for the control) with Eimeria spp./C. perfringens. Results: Infected birds fed the BLJ-supplemented diet exhibited an improved feed conversion ratio throughout the trial (P < 0.01), a higher villus height and villus height/crypt depth ratio, and reduced intestinal C. perfringens counts, liver C. perfringens carriage, gut lesion scores and serum fluorescein isothiocyanate dextran (FITC-D) concentrations at 7 d postinfection compared with those of birds without BLJ supplementation (P < 0.05). NE-infected birds fed BLJ exhibited significantly upregulated claudin-1 and IGF-2 mRNA levels (P < 0.05), increased A20 mRNA expression and significantly downregulated TRAF-6, TNFSF15 and TOLLIP mRNA levels in the jejunum at 7 d post-infection compared with those in birds without BLJ supplementation (P < 0.05). Compared with the uninfected and untreated birds, the uninfected birds fed BLJ displayed increased relative abundances of Lactobacillus and Coprococcus but reduced Rikenellaceae levels. Compared with the unsupplemented NE-challenged birds, infected birds fed BLJ showed an increased relative abundance of Unclassified_ Lachnospiraceae and a significantly decreased relative abundance of Erysipelotrichaceae. Conclusion: BLJ supplementation improved growth performance and gut health in NE-infected broiler chickens by strengthening the intestinal barrier function, positively modulating the gut microbiota community and differentially regulating intestinal immune responses. Our results also suggested that adding BLJ effectively controlled NE infections after experimental Eimeria and Clostridium perfringens coinfection.

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Section: Discussionmentioning

confidence: 99%

Dietary encapsulated essential oils and organic acids mixture improves gut health in broiler chickens challenged with necrotic enteritis

Pham

Kan

Huang³

et al. 2020

J Animal Sci Biotechnol

105

101

View full text Add to dashboard Cite

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“…The features of healthy GIT are hard to explain, especially because they depend on a multitude of covariates related to diet, digestion and absorption processes, plasticity and resilience of the gastroenteric immunity, morpho-physiological integrity of the gastrointestinal (GI) barrier, and microbiota stability. Nonetheless, Celi and colleagues [4] were able to thoroughly describe the gut health concept emphasizing the importance of microbiome-gut balanced symbiotic relationship and the relevant influence of intestinal functionality towards animal health and productiveness.…”

Section: Introductionmentioning

confidence: 99%

Effects of Alternative Administration Programs of a Synbiotic Supplement on Broiler Performance, Foot Pad Dermatitis, Caecal Microbiota, and Blood Metabolites

Brugaletta

Cesare

Zampiga

et al. 2020

Animals

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This research investigated the effects of different synbiotic administration programs on broiler productive performance and foot pad dermatitis (FPD). Molecular insights on caecal microbiota and plasma metabolomics were also performed. - A total of 1000 one-day-old male chicks were grouped by the synbiotic treatment. The synbiotic was either sprayed as gel droplets onto newly hatched chicks at the hatchery (100 g/10,000 birds) or supplemented in-feed during the entire rearing period (1000, 500, and 250 g/ton according to feeding phase), or both. Only the treatments’ combination produced significant results in comparison with the control group (untreated), improving feed conversion ratio from 14 to 29 d and in the overall period of the trial (1.570 vs. 1.509 and 1.643 vs. 1.596, respectively; p < 0.05) while lowering FPD occurrence at slaughter (17% vs. 5%; p < 0.05). These findings can be related to significant variations of caecal microbiota, like higher Firmicutes to Bacteroidetes ratio (with favorable implications for host’s energy-harvesting potential from the diet) and more beneficial microbial consortium presumably sustaining eubiosis. Overall, these results indicate that administering synbiotics through gel droplets at the hatchery combined to in-feed supplementation for the whole growing cycle positively affects broiler feed efficiency and welfare.

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“…In the digestive tract, fermentation of fibre causes reduction in luminal pH, creating a hostile environment for harmful microorganisms, reducing the pathogenic load of fish and potentiating the immune system, similarly to prebiotics (Burr, Gatlin, & Ricke, ; Merrifield & Ringø, ; Nayak, ; Radecki & Yokoyama, ). This fermentation also produces short‐chain fatty acids (SCFA), which are used as energy source in various metabolic pathways, reflecting on higher animal performance (Celi et al, ; Ferreira, ; Ríos‐Covián et al, ).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of immune response and performance of silver catfish fed functional linseed fibres in response to hypoxia stress

et al. 2019

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This study was conducted to evaluate the immunostimulating activity and growth promoting of diets supplemented with different rations of soluble and insoluble linseed fibre to Rhamdia quelen under hypoxia-induced acute stress. For this reason, soluble and insoluble fractions of linseed fibre were concentrated separately and combined into four ratios (1:0.5; 1:1; 1:2 and 1:4), which were added to the diets of silver catfish (6.43 ± 0.12 g) and evaluated in a biological assay, along with a control diet (without addition of linseed fibre). After being fed the experimental diets for 45 days, specimens of silver catfish were submitted to hypoxia-induced acute stress.They were kept out of water for 60 s. Immediately afterwards, blood and cutaneous mucus were collected for subsequent determination of immunological indicators and stress. After stress, the fish were weighed and measured for performance parameter calculation. The experimental design was completely randomized with five treatments and four replications. The data underwent analysis of variance and the means were compared by Tukey's test (p < .05). The fish fed diets containing the 1:2 and 1:4 soluble:insoluble fibre ratios, showed higher total protein content, globulin, plasma alkaline phosphatase activity, and performance in addition to higher mucoprotein content in the cutaneous mucus of the fish. Regardless of their ratio in the diet, linseed fibre provided higher plasma levels of total immunoglobulins and reduction in cortisol levels. The 1:1, 1:2 and 1:4 diets led to higher levels of total immunoglobulins and alkaline phosphatase activity in cutaneous mucus. The results indicate that linseed fibre has a stress-reduction, immunostimulant and a growth promoter effect on silver catfish. The 1:2 or 1:4 soluble: insoluble fibre ratios provided greater stimulation of the target immunological indicators and performance. K E Y W O R D S dietary fibre, immunostimulant, Rhamdia quelen, stress | 3061 ADORIAN et Al.

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Gastrointestinal functionality in animal nutrition and health: New opportunities for sustainable animal production

Cited by 308 publications

References 119 publications

Dietary encapsulated essential oils and organic acids mixture improves gut health in broiler chickens challenged with necrotic enteritis

Dietary encapsulated essential oils and organic acids mixture improves gut health in broiler chickens challenged with necrotic enteritis

Effects of Alternative Administration Programs of a Synbiotic Supplement on Broiler Performance, Foot Pad Dermatitis, Caecal Microbiota, and Blood Metabolites

Evaluation of immune response and performance of silver catfish fed functional linseed fibres in response to hypoxia stress

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