Gastrointestinal Motility Disorders: An Update

Abstract

Gastrointestinal motility disorders encompass a wide array of signs and symptoms that can occur anywhere throughout the luminal gastrointestinal tract. Motility disorders are often chronic in nature and dramatically affect patients’ quality of life. These prevalent disorders cause a tremendous impact both to the individual patient and to society as a whole. Significant progress has been made over the last 5 years in understanding the etiology and pathophysiology of gastrointestinal motility disorders. This clinical update will focus on seven of the most common gastrointestinal motility disorders (achalasia, non-achalasia esophageal motility disorders, dyspepsia, gastroparesis, chronic intestinal pseudo-obstruction, irritable bowel syndrome, and chronic constipation) with an emphasis on current treatment options and new therapeutic modalities.

Domperidone Treatment for Gastroparesis: Demographic and Pharmacogenetic Characterization of Clinical Efficacy and Side-Effects

“…Domperidone is considered to have a good safety profile when administered orally [38,39]. An early study of oral domperidone in 287 adults with gastroparesis did not identify any ECG changes after 4 weeks of treatment or in the subsequent 4 week double-blind phase [40].…”

Nationwide survey on adult type chronic intestinal pseudo-obstruction in surgical institutions in Japan

“…4 Effectiveness of surgical treatment and the types of the diseased bowel L-type, the large bowel type; S-type, the small bowel type; L ? S-type, the large and small bowel type idiopathic megacolon or chronic constipation with colonic dilatation; however, the diagnostic criteria of these entities per se have not been determined yet [7,8]. More comprehensive discussion will be needed to clarify this issue.…”

Effects of Gamisoyo-San Decoction, a Traditional Chinese Medicine, on Gastrointestinal Motility

“…GI motility disorders can occur anywhere in the lumen of the GI tract and produce an extensive array of symptoms [10]. Patients with GI motility disorders have a reduced quality of life [11][12][13].…”