Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticles

Hillyer, Julián F.; Albrecht, Ralph M.

doi:10.1002/jps.1143

Cited by 606 publications

(230 citation statements)

References 28 publications

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“…Furthermore, the presence of nospherical nanoparticles might influence the penetration ability of the sample as well as its cytotoxicity. Large sizes (15 nm), as expected, with low penetration into cells exhibited no cytotoxicity even at high concentrations (6.3 mM) [45]. A similar behavior wasobserved with other very small 1-2 nm AuNPs that were highly toxic in all healthy or cancer cells.…”

Section: Particle Size Effectsupporting

confidence: 83%

“…The high penetration ability of small nanoparticles into cells, the considerable penetration and accumulation of AuNPs, for example, in the different animal or human organs (liver, spleen, lungs,..) and their slow elimination areall connected with their high toxicity. The 4-nmgold nanoparticles were reported toenter via the digestive tract and distribute among several organs [45]. The penetration into various tissues via the digestive tract considerably decreased with an increase in the particle size (10,28 and 58nm).…”

Section: Particle Size Effectmentioning

confidence: 99%

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On Biodecorated Gold Nanoparticles Distributed within Tissues and Cells

Capek¹

2015

JNMR

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Vocabulary EndocytosisIt is an energy-using process by which cells absorb molecules (such as proteins) by engulfing them. It is used by all cells of the body because most substances important to them are large polar molecules that cannot pass through the hydrophobic plasma or cell membrane. The opposite process is exocytosis. Lactate dehydrogenase (LDH)It is of medical significance because it is found extensively in body tissues, such as blood cells and heart muscle. Because it is released during tissue damage, it is a marker of common injuries and disease. The MTT assayIt is a colorimetric assay for assessing cell viability. WSTs (water soluble tetrazolium salts)These are a series of other water soluble dyes for MTT assays, developed to give different absorption spectra of the formed formazans. WST-1 is advantageous over MTT in that it is reduced outside cells. WST assays (1) can be read directly (unlike MTT that needs a solubilization step), give a more effective signal than MTT, and decrease toxicity to cells (unlike cell-permeable MTT, and its insoluble formazan that accumulate inside cells). BiotinIt also known as vitamin H or coenzyme R, is a water-soluble B-vitamin (vitamin B7). Biotin has an unusual structure, with two rings fused together via one of their sides. The two rings are ureido and thiophene moieties. Biotin is a heterocyclic, S-containing monocarboxylic acid.

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Section: Particle Size Effectsupporting

confidence: 83%

Section: Particle Size Effectmentioning

confidence: 99%

On Biodecorated Gold Nanoparticles Distributed within Tissues and Cells

Capek¹

2015

JNMR

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“…The orally ingested particulates that have been reported in peripheral blood and urine, range in size up to 150 µm in diameter [For more details, see the review of Volkheimer,40,41]. Persorbed particulates have been found in various tissues, such as blood, bile, urine, lymph nodes, spleen, lung, kidney and brain [16,44]. Persorption is observed in a wide range of animal species including both fishes and mammals [27,42].…”

mentioning

confidence: 99%

Persorption Mechanisms of Luminal Antigenic Particulates via Apoptotic Epithelial Cells of Intestinal Villi into Systemic Blood Circulation in Orally Immunized Rats

Yuji

Fujimoto

Miyata

et al. 2007

The Journal of Veterinary Medical Science

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ABSTRACT. The possibility of persorption of prefixed bovine serum albumin-coated sheep erythrocytes (BSA-SEs) from mucous epithelial cells and its mechanisms were investigated in rats orally immunized by BSA for 14 consecutive days. On the day after the final oral immunization, the rats were duodenally perfused by BSA-SEs or non-coated SEs. BSA-SEs were also duodenally perfused in nonimmunized rats. Thirty min after perfusion, BSA-SEs were significantly more engulfed by late-apoptotic-stage villous columnar epithelial cells in the orally immunized rats than those in other experiments. The specific antibody (SpAb) was detected on the surfaces of BSA-SEs in rats with oral immunization. In Peyer's patches of all animals, no SEs reached the follicle-associated epithelium, because of the close attachment of follicle-associated intestinal villi and the thick mucous layer. BSA-SEs were more frequently persorbed into portal blood in the orally immunized rats than in other rats. Small numbers of BSA-SEs or SEs were detected in the systemic blood of all animals. BSA-SEs were also histologically found in the blood vessels of the liver, but not in mesenteric lymph nodes. These findings suggest that sensitized antigenic particulates are taken up by late-apoptotic-stage villous columnar epithelial cells in the small intestine and are finally persorbed into the systemic blood circulation. The uptake of antigenic particulates might be mediated by its luminal SpAb.

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“…A number of studies have reported the use of microscopy or spectroscopy combined with fluo rescent or reflective microparticles to monitor intestinal closure, transport and translocation in animals [88][89][90][91][92][93] . In general, the protocols used in these investigations first involved feeding animals a dose of a contrast agent such as fluo rescein isothiocyanate (FITC)-labelled dextran 88,89 , fluores cently tagged polystyrene microspheres 90,91 , colloidal gold nanoparticles 92 or iron oxide nano particles 93 . The uptake of contrast agent from the intestine into the blood, or into specific cells or tissues, was then assessed using spectroscopy or microscopy.…”

Section: Microbiota Changesmentioning

confidence: 99%

The potential role of optical biopsy in the study and diagnosis of environmental enteric dysfunction

Thompson

Hughes

Anastasova

et al. 2017

Nat Rev Gastroenterol Hepatol

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| Environmental enteric dysfunction (EED) is a disease of the small intestine affecting children and adults in low and middle income countries. Arising as a consequence of repeated infections, gut inflammation results in impaired intestinal absorptive and barrier function, leading to poor nutrient uptake and ultimately to stunting and other developmental limitations. Progress towards new biomarkers and interventions for EED is hampered by the practical and ethical difficulties of cross-validation with the gold standard of biopsy and histology. Optical biopsy techniques -which can provide minimally invasive or noninvasive alternatives to biopsy -could offer other routes to validation and could potentially be used as point-of-care tests among the general population. This Consensus Statement identifies and reviews the most promising candidate optical biopsy technologies for applications in EED, critically assesses them against criteria identified for successful deployment in developing world settings, and proposes further lines of enquiry. Importantly, many of the techniques discussed could also be adapted to monitor the impaired intestinal barrier in other settings such as IBD, autoimmune enteropathies, coeliac disease, graft-versus-host disease, small intestinal transplantation or critical care. Members of the board and experts met to discuss the horizon scan in London, UK, in November 2015 and San Francisco, USA, in February 2016. Literature searches were performed using Web of Science, as well as through the advice of the advisory board and experts. The results of the horizon scan are presented in this Consensus Statement, which entails a review of EED, a discussion of technologies deemed relevant to EED (based on literature searches and the opinions of the advisory board and experts), and a series of recommendations for the future application of the rele vant technologies to the study and diagnosis of EED. In the Recommendations section, each technology has been assessed according to its suitability for application to EED and this assessment includes an evaluation of the cost, invasiveness and appropriateness for developing countries of each device and/or technique. This assessment was performed in a qualitative manner based on currently available information (for example, the present cost and size of the devices) and the opinions of the authors as to feasible future develop ment. Technique suitability for use in developing countries was determined in a qualitative manner after consideration of the need for advanced infrastructure and high levels of training for either system use or data analysis. Probable deployment time scales have also been assigned to each technique based on the current states of development and the degree of valid ation work that will be required before application to EED. These timescales have been tentatively defined as short-term (suitable for deployment immediately or within ~1 year), mediumterm (suit able for deployment within ~1-3 years) and long-term (suitable for deployme...

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Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticles

Cited by 606 publications

References 28 publications

On Biodecorated Gold Nanoparticles Distributed within Tissues and Cells

On Biodecorated Gold Nanoparticles Distributed within Tissues and Cells

Persorption Mechanisms of Luminal Antigenic Particulates via Apoptotic Epithelial Cells of Intestinal Villi into Systemic Blood Circulation in Orally Immunized Rats

The potential role of optical biopsy in the study and diagnosis of environmental enteric dysfunction

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