Gastroschisis and young mothers: What makes them different from other mothers of the same age?

Rittler, Mónica; Campaña, Hebe; Ermini, M; Gili, Juan Antonio; Poletta, Fernando A.; Pawluk, Mariela Soledad; Giménez, Lucas Gabriel; Cosentino, Viviana; Castilla, Eduardo E.; López-Camelo, Jorge S.

doi:10.1002/bdra.23374

Cited by 29 publications

(33 citation statements)

References 35 publications

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“…In a previous study (Rittler et al, ), we showed that a history of miscarriages was the main risk factor for gastroschisis. To our knowledge, an association between gastroschisis and pregnancy losses has only been mentioned by Getz et al ().…”

Section: Discussionmentioning

confidence: 71%

“…They found that the risk factor was the short interval and the risk increased if the previous pregnancy ended in a miscarriage. On the contrary, in the study of Rittler et al () the identified risk factor was the miscarriage, regardless of the inter‐pregnancy interval.…”

Section: Discussionmentioning

confidence: 82%

“…Vascular disruption has been suggested to cause certain defects, such as club foot and gastroschisis (Van Allen, ; Lubinsky, ), while Rittler et al () demonstrated an association between miscarriages and gastroschisis and proposed a disruptive mechanism for both.…”

Section: Introductionmentioning

confidence: 99%

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Association between a Maternal History of Miscarriages and Birth Defects

Campaña

Rittler

Gili

et al. 2017

Birth Defects Research

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Results: Control mothers with vs. without previous miscarriages were older, had had more pregnancies, and were less educated. Three risk models for miscarriages were observed: highest risk for gastroschisis, omphalocele, and talipes; only one miscarriage for spina bifida, and only two or more for hypospadias.Conclusion: Based on these three models, the following common factors for each BD/miscarriage association are proposed: infertility therapies for hypospadias, vascular disruption for gastroschisis and talipes, while for spina bifida, the trophoblastic cell residue theory could not be discarded.

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Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 82%

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Association between a Maternal History of Miscarriages and Birth Defects

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Rittler

Gili

et al. 2017

Birth Defects Research

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“…Additionally, among multiparous and multigravida mothers, a change in paternity since the previous pregnancy has been associated with gastroschisis (5). Studies have also indicated possible age-specific associations between gastroschisis and prior pregnancy loss (8), as well as with certain infections (9). The findings in this report are subject to at least three limitations.…”

Section: Discussionmentioning

confidence: 99%

Increasing Prevalence of Gastroschisis — 14 States, 1995–2012

Jones¹,

Isenburg²,

Salemi³

et al. 2016

MMWR Morb. Mortal. Wkly. Rep.

169

142

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with all other racial/ethnic groups included in the total). The gastroschisis case definition was based on the British Pediatric Association Classification of Diseases code (756.71) or the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) code for gastroschisis (756.73, or before 10/1/2009, 756.79, with verification to confirm cases of gastroschisis, because the previous code was shared with omphalocele). Gastroschisis cases included live births, fetal deaths, † and elective terminations. § Data were pooled at CDC, and gastroschisis prevalence was calculated for each year, maternal age group, and race/ethnicity. Prevalence was calculated as number of gastroschisis cases among all birth outcomes divided by the total number of live births. The denominators of total number of live births in the same catchment area as the birth defects surveillance program were reported by states or obtained from public use data files. Poisson exact methods were used to calculate 95% CIs for each prevalence estimate. Prevalence ratios were calculated by dividing the prevalence during 2006-2012 by the prevalence during 1995-2005, and CIs for the prevalence ratios were calculated using Poisson regression.Because the comparison of prevalence between the two study periods involved an artificial breakpoint during the 18-year data span and only examined pooled prevalence within those periods, joinpoint regression analysis was used to identify statistically significant changes in the annual prevalence of gastroschisis over the course of the entire study period (1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012). Joinpoint regression initially models annual trend data by fitting a straight line (i.e., zero joinpoints). Then, joinpoints are added, one at a time, and a Monte Carlo permutation test is used to determine the optimal number of joinpoints. Each joinpoint in the final model corresponds to a significant change in the trend, and an AAPC and its 95% CI are calculated to describe how the rate changes within each time interval (3). The estimated overall percent change was calculated by first converting the AAPC to the projected single year change in prevalence and then exponentiating to the number of years studied minus one to estimate the total increase throughout the 18 years. This gives the magnitude of the increase, which

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“…Although young maternal age has been identified as a risk factor for G, pregnancy loss and Chlamydia exposure in young women (16 -25 years old) seem to be risk factors for G (p < 0.002) [7] [8]. Despite the unknown etiology mechanism of formation of paraumbilical congenital defect in G, some authors suggest that the defect might occur through regression or precocious lesion of one of the omphalomesenteric arteries in the embryonic phase [9] through genetic teratogenic alterations and/or drugs, such as acetylsalicylic acid, pseudoephedrine, and acetaminophen and smoking habit would also be involved in its etiology [10].…”

Section: Introductionmentioning

confidence: 97%

Are Fetuses Affected by Gastroschisis Benefited from Prenatal Maternal Corticosteroid Use and Early Parturition?

Massimo¹,

Kopaz²,

Novo³

et al. 2019

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Introduction: Gastroschisis (G) is a congenital defect of the abdominal walls through which intestinal herniation and permanent exposure to amniotic liquid (AL) and its components are developed at the end of gestation. G affects mostly fetuses from young mothers under 25-29 years old, but it occurs more often in fetuses of mothers' ages between 12-15 years old. Some authors assert that it is not the low weight, nor the low gestational age that influences mortality. In addition to morphological alterations, histological alterations are characterized by disorganization, distribution and the degree of ganglia maturity and myenteric plexuses. The literature describes parturition anticipation of G disease carriers to minimize damages to intestinal loops. There are studies suggesting corticosteroids at the end of gestation in order to avoid morphological and histological damages to the intestinal loop. Objective: Identify if live newborn infants delivery anticipation, that is, gestational date less than 37 weeks and prenatal maternal use of corticosteroid were benefited from early enteral diet, namely, less than 10 post-surgery days. Material and Method: From 33 newborns researched in the period from 2010 to 2014; 28 newborns full records were included in the study with 15.2% mortality rate. These newborns were divided in 3 groups according to maternal age: 6 newborns from mothers' age between 16-20 years old (Group 1); 14 newborns from mothers' age between 21-25 years old (Group 2) and 8 newborns from mothers' age between 26-29 years old (Group 3). Gestational age at birth and prenatal maternal usage of corticosteroid and beginning oral feed

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Gastroschisis and young mothers: What makes them different from other mothers of the same age?

Abstract: A previous pregnancy loss was identified as the main risk factor for gastroschisis, while an increased use of sex hormones, perhaps related to the previous loss, could trigger a disruptive mechanism, due to their thrombophilic effect.

Cited by 29 publications

References 35 publications

Association between a Maternal History of Miscarriages and Birth Defects

Association between a Maternal History of Miscarriages and Birth Defects

Increasing Prevalence of Gastroschisis — 14 States, 1995–2012

Are Fetuses Affected by Gastroschisis Benefited from Prenatal Maternal Corticosteroid Use and Early Parturition?

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