“…Fifty-six studies (76.7%) had a high risk of bias in patient selection (11-13, 17, 25-27, 29-31, 34, 36-39, 41-44, 46, 47, 50-54, 57, 58, 60-72, 74-79, 81, 83-86, 88-91), mostly due to the case-control study design (n = 54, 74%) (11-13, 17, 25-27, 29-31, 34, 36-39, 41-44, 46, 47, 50-54, 57, 58, 60-64, 66-72, 75-79, 81, 83-86, 88-91). Two studies had low risk of bias for patient selection because of random participant sampling, and due to appropriate exclusion of participants (55,87), while 15 studies (20.5%) did not provide sufficient information for risk classification (10,14,28,32,33,35,40,45,48,49,56,59,73,80,10.3389/fmed.2022.1018937 (10,17,(87)(88)(89)(90)(91). Of these, 31 studies (86.1%) conducted external validation and were included in the meta-analysis (10,17,.…”