2023
DOI: 10.1093/pnasnexus/pgad480
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GASZ self-interaction clusters mitochondria into the intermitochondrial cement for proper germ cell development

Junru Miao,
Chuanyun Wang,
Wei Chen
et al.

Abstract: Mitochondrial features and activities vary in a cell type- and developmental stage-dependent manner to critically impact cell function and lineage development. Particularly in male germ cells, mitochondria are uniquely clustered into intermitochondrial cement (IMC), an electron-dense granule in the cytoplasm to support proper spermatogenesis. But it remains puzzling how mitochondria assemble into such a stable structure as IMC without limiting membrane during development. Here, we showed that GASZ, a mitochond… Show more

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