GATA Regulation and Function During the Ovarian Life Cycle

The Ovulatory Signal Precipitates LRH-1 Transcriptional Switching Mediated by Differential Chromatin Accessibility

“…For instance, GATA transcription factors have been shown to cooperate as pioneer factors with other nuclear receptors, such as AR and ERa, to initiate specific transcriptional programs (Zaret and Carroll, 2011). Multiple GATA factors are expressed in granulosa cells, and it has been shown that these have redundant functions, since their simultaneous gene inactivation is necessary to cause infertility (Bennett-Toomey and Stocco, 2018). GATA-4 and GATA-6 granulosa double KO female mice fail to ovulate due to a lack of follicular development (Bennett et al, 2012).…”

Screening of targeted panel genes in Brazilian patients with primary ovarian insufficiency

“…In addition, GATA4 and GATA6 play a pivotal role in follicle assembly, granulosa cell differentiation, postnatal follicle growth, and luteinization. Conditional knockdown of these factors has led to female infertility at any stage of ovarian development [ 23 ]. Moreover, GATA factors have been associated with ovarian development in different species including mammals, fish, birds, and fruit fly [ 23 ].…”

“…Conditional knockdown of these factors has led to female infertility at any stage of ovarian development [ 23 ]. Moreover, GATA factors have been associated with ovarian development in different species including mammals, fish, birds, and fruit fly [ 23 ]. Some in vitro studies have shown that steroidogenic enzymes implicated in the synthesis of progesterone, androgens, and estrogens may be regulated by GATA4 and GATA6.…”

“…Some in vitro studies have shown that steroidogenic enzymes implicated in the synthesis of progesterone, androgens, and estrogens may be regulated by GATA4 and GATA6. In the absence of GATA4 and GATA6 expression, estradiol synthesis is impaired, and its inactivation is also stimulated by high expression of CYP1B1 [ 23 ]. Furthermore, GATA4 interacts with SF1/ NR5A1 and LRH1/ NR5A2 to activate the promoter of 3βHSD2 , AMH , inhibin-α , and CYP19A1 , indicating GATA4 as a partner of these proteins in the regulation of ovarian steroidogeneses [ 23 ].…”

“…In the absence of GATA4 and GATA6 expression, estradiol synthesis is impaired, and its inactivation is also stimulated by high expression of CYP1B1 [ 23 ]. Furthermore, GATA4 interacts with SF1/ NR5A1 and LRH1/ NR5A2 to activate the promoter of 3βHSD2 , AMH , inhibin-α , and CYP19A1 , indicating GATA4 as a partner of these proteins in the regulation of ovarian steroidogeneses [ 23 ]. Interestingly, no pathogenic variants in GATA4 have been reported in the POI phenotype, although heterozygous missense variants in this gene are associated with 46, XY DSD with or without congenital heart defects [ 51 , 52 ].…”