Gatifloxacin

Al‐Abdullah, Ebtehal S.

doi:10.1016/b978-0-12-397220-0.00005-2

Cited by 12 publications

(5 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The NMR assignment of gatifloxacin in D 2 O was carried out as reported in the literature [ 70 ]. The proton signal of –CH- linked to the secondary amine of gatifloxacine was shifted from 4.12 ppm to 4.07 ppm after the addition of Cross-PEI-800 ( Figure 6 a,b, full spectra shown in Figures S13–S15 in the Supplementary Materials ).…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Coordination Properties of a Water-Soluble Material by Cross-Linking Low Molecular Weight Polyethyleneimine with Armed Cyclotriveratrilene

Coghi

et al. 2021

Polymers

View full text Add to dashboard Cite

In this study, a full organic and water-soluble material was synthesized by coupling low molecular weight polyethylenimine (PEI-800) with cyclotriveratrilene (CTV). The water-soluble cross-linked polymer contains hydrophobic holes with a high coordination capability towards different organic drug molecules. The coordinating capability towards hydrophilic drugs (doxorubicin, gatifloxacin and sinomenine) and hydrophobic drugs (camptothecin and celastrol) was analyzed in an aqueous medium by using NMR, UV-Vis and emission spectroscopies. The coordination of drug molecules with the armed CTV unit through hydrophobic interactions was observed. In particular, celastrol exhibited more ionic interactions with the PEI moiety of the hosting system. In the case of doxorubicin, the host–guest detachment was induced by the addition of ammonium chloride, suggesting that the intracellular environment can facilitate the release of the drug molecules.

show abstract

Section: Resultsmentioning

confidence: 99%

Synthesis and Coordination Properties of a Water-Soluble Material by Cross-Linking Low Molecular Weight Polyethyleneimine with Armed Cyclotriveratrilene

Coghi

et al. 2021

Polymers

View full text Add to dashboard Cite

show abstract

“…Gatifloxacin was shown to be highly active against both penicillin-susceptible and penicillin-resistant strains of S. pneumoniae , the main pathogen behind the bacterial pneumonia infection. 278 This 8-methylfluoroquinolone derivative has been used to treat lung, sinus, skin, and urinary-tract infections but has also been shown to produce dangerous changes in blood-sugar levels. Although the complete mechanism leading to hypoglycemia is not yet fully understood, experiments have shown that it can stimulate insulin release and block the ATP-sensitive potassium channels of pancreatic cells, which can both lead to hypoglycemia.…”

Section: Fluorine-containing Pharmaceuticals Withdrawn From the Marketmentioning

confidence: 99%

“…Approved for sale and commercialized with the brand name Tequin by Bristol-Myers Squibb in 1999, gatifloxacin 158 (Figure ) is a member of the fourth and latest generation of the fluoroquinolone family of antibiotics. Gatifloxacin was shown to be highly active against both penicillin-susceptible and penicillin-resistant strains of S. pneumoniae , the main pathogen behind the bacterial pneumonia infection . This 8-methylfluoroquinolone derivative has been used to treat lung, sinus, skin, and urinary-tract infections but has also been shown to produce dangerous changes in blood-sugar levels.…”

Section: Fluorine-containing Pharmaceuticals Withdrawn From the Marketmentioning

confidence: 99%

Chemical Aspects of Human and Environmental Overload with Fluorine

et al. 2021

View full text Add to dashboard Cite

Over the last 100–120 years, due to the ever-increasing importance of fluorine-containing compounds in modern technology and daily life, the explosive development of the fluorochemical industry led to an enormous increase of emission of fluoride ions into the biosphere. This made it more and more important to understand the biological activities, metabolism, degradation, and possible environmental hazards of such substances. This comprehensive and critical review focuses on the effects of fluoride ions and organofluorine compounds (mainly pharmaceuticals and agrochemicals) on human health and the environment. To give a better overview, various connected topics are also discussed: reasons and trends of the advance of fluorine-containing pharmaceuticals and agrochemicals, metabolism of fluorinated drugs, withdrawn fluorinated drugs, natural sources of organic and inorganic fluorine compounds in the environment (including the biosphere), sources of fluoride intake, and finally biomarkers of fluoride exposure.

show abstract

“…Fluoroquinolones are considered one of the most effective drug classes for the treatment of ocular bacterial infections, mainly due to their broad spectrum activity and high potency [ 5 ]. Moxifloxacin (MOX) and gatifloxacin (GTX) solutions were introduced in 2003 as two new fourth generation fluoroquinolones for the treatment of BC [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Gatifloxacin Loaded Nano Lipid Carriers for the Management of Bacterial Conjunctivitis

Joshi,

Youssef,

Ghonge

et al. 2023

Antibiotics

View full text Add to dashboard Cite

Bacterial conjunctivitis (BC) entails inflammation of the ocular mucous membrane. Early effective treatment of BC can prevent the spread of the infection to the intraocular tissues, which could lead to bacterial endophthalmitis or serious visual disability. In 2003, gatifloxacin (GTX) eyedrops were introduced as a new broad-spectrum fluoroquinolone to treat BC. Subsequently, GTX use was extended to other ocular bacterial infections. However, due to precorneal loss and poor ocular bioavailability, frequent administration of the commercial eyedrops is necessary, leading to poor patient compliance. Thus, the goal of the current investigation was to formulate GTX in a lipid-based drug delivery system to overcome the challenges with the existing marketed eyedrops and, thus, improve the management of bacterial conjunctivitis. GTX-NLCs and SLNs were formulated with a hot homogenization–probe sonication method. The lead GTX-NLC formulation was characterized and assessed for in vitro drug release, antimicrobial efficacy (against methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa), and ex vivo permeation. The lead formulation exhibited desired physicochemical characteristics, an extended release of GTX over a 12 h period, and was stable over three months at the three storage conditions (refrigerated, room temperature, and accelerated). The transcorneal flux and permeability of GTX from the GTX-NLC formulation were 5.5- and 6.0-fold higher in comparison to the commercial eyedrops and exhibited a similar in vitro antibacterial activity. Therefore, GTX-NLCs could serve as an alternative drug delivery platform to improve treatment outcomes in BC.

show abstract

Gatifloxacin

Cited by 12 publications

References 69 publications

Synthesis and Coordination Properties of a Water-Soluble Material by Cross-Linking Low Molecular Weight Polyethyleneimine with Armed Cyclotriveratrilene

Synthesis and Coordination Properties of a Water-Soluble Material by Cross-Linking Low Molecular Weight Polyethyleneimine with Armed Cyclotriveratrilene

Chemical Aspects of Human and Environmental Overload with Fluorine

Gatifloxacin Loaded Nano Lipid Carriers for the Management of Bacterial Conjunctivitis

Contact Info

Product

Resources

About