Gaucher disease with jawbone involvement: a case report

Ahmadieh, Azadeh; Farnad, Fariborz; Sedghizadeh, Parish P.

doi:10.1186/1752-1947-8-360

Cited by 13 publications

(23 citation statements)

References 13 publications

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“…Clinically, it presents bilaterally and symmetrically in long bones. Gaucher's disease, the most common lysosomal storage disease, can also affect the gnathic bones [22]. In Gaucher's disease, a genetic mutation causes lipids to accumulate in different organs, including bones.…”

Section: Discussionmentioning

confidence: 99%

“…In Gaucher's disease, a genetic mutation causes lipids to accumulate in different organs, including bones. The histopathologic exam demonstrates vacuolated lipid-laden reticuloendothelial cells (Gaucher's cells) infiltrating the connective tissue with enlarged granular cytoplasm and round displaced nuclei [22]. Furthermore, systemic metabolic and lipid diseases (i.e.…”

Section: Discussionmentioning

confidence: 99%

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Primary Xanthoma of the Mandible: Report of a Rare Case

Morel

Kelsch

Nolan

2015

Head and Neck Pathol

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Xanthoma is a lesion most commonly seen in soft tissues such as the skin, subcutis, or tendon sheaths. Xanthoma formation is often associated with primary or secondary hyperlipidemia. Primary bone xanthomas are extremely rare benign bone lesions not associated with hyperlipidemia, histopathologically characterized by histiocytes, abundant lipid containing macrophages (foam cells), and multinucleated giant cells. Cholesterol clefts can be found in the medullary bone. Less than ten cases of xanthoma in the mandible have been reported. We present a rare primary intrabony xanthoma in a normolipidemic patient.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Primary Xanthoma of the Mandible: Report of a Rare Case

Morel

Kelsch

Nolan

2015

Head and Neck Pathol

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“…A biópsia pode ser necessária em alguns casos, para o diagnóstico definitivo das lesões dolorosas dos maxilares e a fim de descartar outras condições odontogênicas ou não, no diagnóstico diferencial. 22 Adicionalmente, no grupo de doenças inusuais, Mohammed et al 23 apresentou um caso de osteoma osteóide, que é um tumor ósseo benigno, cuja dor inexplicavelmente foi aliviada pela ingestão de analgésicos. O dilema diagnóstico no caso em questão foi agravado por sua associação incomum com os dentes.…”

Section: Discussionunclassified

Odontalgia não odontogênica: levantamento e revisão da literatura atual

Arruda¹,

Silva²,

Moreno³

et al. 2018

Arch Health Invest

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ResumoIntrodução: Apesar da maior compreensão acerca da dor orofacial nos últimos anos, o diagnóstico preciso da dor ainda é um desafio na odontologia contemporânea. Muitos distúrbios na região de cabeça e pescoço são reconhecidos para se referir à dor de estruturas dentárias ou que simulam a odontalgia. Objetivo: O objetivo desse estudo foi realizar uma revisão de literatura atual de séries e/ou relatos de casos de pacientes portadores de odontalgia de natureza não odontogênica a fim de contribuir na elucidação dos diagnósticos diferenciais e discutir os principais achados clínicos. Material e Método: A revisão da literatura foi elaborada em Agosto de 2017 com base em artigos publicados na língua inglesa, do banco de dados Medline (PubMed). Foram utilizadas pesquisas do período compreendido entre 1968 e 2016 para determinar o mapeamento dos casos dos pacientes. Os dados foram arquivados em ano da publicação, idade, gênero, número de casos, localização anatômica e diagnóstico diferencial. Resultados: Vinte e quatro artigos foram analisados. Diferentes diagnósticos e condutas foram tomadas nas odontalgias não odontogênicas. Conclusão: É pertinente concluir que o diagnóstico diferencial entre a odontalgia e as doenças de natureza não odontogênica é imprescindível a fim de promover aos pacientes tratamentos conservadores, quando possíveis e melhores prognósticos evitando sobremaneira a mutilação dos dentes, tratamentos endodônticos desnecessários e terapêuticas tardias nos casos de neoplasias malignas. Descritores: Odontalgia; Dor facial; Diagnóstico. AbstractIntroduction: Despite the increased understanding about orofacial pain in recent years, the accurate diagnosis of pain is still a challenge in contemporary dentistry. Many disturbances in head and neck region are recognized to refer to pain of dental structures or that simulate the toothache. Objective: The aim of this study was to conduct a review of current literature series and/or case reports of patients with toothache of non-odontogenic in order to contribute to the elucidation of the differential diagnoses and discuss the main clinical features. Material and Method: The literature review was realized in November 2016 based on articles published in the English language of database Medline (PubMed). Research used the period between 1968 and 2016 to determine the mapping of cases of patients. The data were archived in the publication year, age, gender, number of cases, anatomical location and differential diagnosis. Results: Twenty-four articles were analyzed. Differential diagnosis and conduct were taken in toothache of non-odontogenic. Conclusion: It is pertinent to conclude that the differential diagnosis between the toothache and non-odontogenic diseases is essential in order to promote conservative treatments to patients, when possible and better prognoses avoiding the teeth mutilation, endodontic treatments and unnecessary late therapeutic in cases of malignant neoplasms.

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“…The mandible is more commonly affected than the maxilla [16]. Various radiographic features in the jaw have been reported, but the most frequent presentations are pseudo-cystic or honeycombed radiolucent lesions, mostly in premolars regions [1,41]. Osteopaenia and loss of trabecularity are commonly observed.…”

Section: Gaucher's Diseasementioning

confidence: 99%

Manifestations of lysosomal storage diseases in the stomatognathic system – a literature review

Machut¹,

Zółtowska²

2019

jos

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The stomatognathic system comprises the mouth, teeth, jaws, pharynx, and related structures associated with mastication, swallowing, and speech. Lysosomal storage diseases (LSDs) are metabolic disorders, which cause an increase of systemic complication and are even life-threatening. They may also lead to a change in the socioeconomic conditions of people suffering from these diseases, and their families. LSDs are inherited in an autosomal recessive pattern. Many syndromes of lysosomal diseases represent anomalies of the craniofacial region and in the oral cavity. For the vast majority, treatment is not required, but for some of them it is necessary to reconstruct the morphology or the proper function. The appearance of the face can have a negative impact on the quality of the patient's life. Breathing, chewing, speaking, smiling, and mimic movements are the consequences of facial deformities. Irregularities of the sensory organs can sometimes be observed-especially of hearing, smell, and sight. The most frequent manifestations of lysosomal diseases in the oral cavity are malocclusion, macroglossia, tooth eruption, and development disorders as well as periodontal disorders, for instance hypertrophy of the gingiva. The population of people suffering from lysosomal diseases often have specific oral health needs compared to the population of generally healthy people.

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Gaucher disease with jawbone involvement: a case report

Cited by 13 publications

References 13 publications

Primary Xanthoma of the Mandible: Report of a Rare Case

Primary Xanthoma of the Mandible: Report of a Rare Case

Odontalgia não odontogênica: levantamento e revisão da literatura atual

Manifestations of lysosomal storage diseases in the stomatognathic system – a literature review

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