GC-MS Analysis of Phytocomponents and Antifungal Activities of Zanthoxylum acanthopodium DC. Collected from Manipur, India

Devi, O. Gangarani; Rao, K.D.P.; Bidalia, Ankita; Wangkheirakpam, Radhapiyari; Singh, O. Tarunkumar

doi:10.9734/ejmp/2015/19353

Cited by 11 publications

(8 citation statements)

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“…These results add to the knowledge of the antimicrobial activity of Z. acanthopodium , previously reported for fruit essential oils, [10,29] fruit methanol extract, [17] and leaf extracts [42] . The present results about ZACL further elucidate the essential oil's role as contributing antibacterial and antifungal agents in the leaves.…”

Section: Resultssupporting

confidence: 81%

Chemical Composition, Antimicrobial, Nitric Oxide Inhibition and Cytotoxic Activity of Essential Oils from Zanthoxylum acanthopodium DC. Leaves and Stems from Vietnam

Diep,

Dung,

Trung

et al. 2023

Chemistry & Biodiversity

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This study was aimed to investigate the chemical composition and biological activities of leaf and stem essential oils of Zanthoxylum acanthopodium DC. from Vietnam. Their chemical composition was analyzed by GC/MS. Antimicrobial activities were evaluated by microdilution broth assay. Anti‐inflammatory activity was evaluated by the ability to inhibit nitric oxide production in macrophage cells. Cytotoxic activity was evaluated using the sulforhodamine B assay on three human cancer cell lines. Forty‐four compounds were identified in the leaf oil, among which dehydroaromadendrane (23.4 %), (E)‐carpacin (17.6 %), 2‐tridecanone (12.2 %), and 9‐methyl‐2‐decanone (11.8 %) were the most abundant. The stem oil contained fifty‐five identified constituents, mainly γ‐gurjunene (51.1 %) and butyl acetate (11.8 %). Both oils exhibited inhibitory effects on three bacterial strains, namely S. aureus, E. coli, P. aeruginosa and a fungal strain C. albican, while showed insignificant effects on B. subtilis, L. fermentum, and S. enterica. Both oils showed weak NO production inhibition in LPS‐induced RAW264.7 cells, but exhibited potent cytotoxic activity against all three tested cell lines SK‐LU‐1, MCF‐7, and HepG2 with the IC50 values ranging from 16.03±0.77 to 35.60±1.62 μg/mL. This is the first report on the antimicrobial, anti‐inflammatory and cytotoxic activities of essential oils from the leaves and stems of Z. acanthopodium.

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Section: Resultssupporting

confidence: 81%

Chemical Composition, Antimicrobial, Nitric Oxide Inhibition and Cytotoxic Activity of Essential Oils from Zanthoxylum acanthopodium DC. Leaves and Stems from Vietnam

Diep,

Dung,

Trung

et al. 2023

Chemistry & Biodiversity

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“…Bioactive compounds from LP and BG were identified using gas chromatography-mass spectrometry (GC/MS) based on the method of Devi et al for LP and Pitakpawasutthi et al for BG with modification [ 20 , 21 ]. The spice extract was dissolved in 70% ethanol at a ratio of 10% w / v , then filtered through a membrane filter.…”

Section: Methodsmentioning

confidence: 99%

Characterization of Lemon Pepper and Black Ginger Extracts and Macroemulsions as Natural Pain Relievers for Spice Stick Balsam Formulation

2023

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Lemon pepper or andaliman (Zanthoxylum acanthopodium) and black ginger (Kaempferia parviflora) are rich in bioactive compounds that possess antioxidant and anti-inflammatory activities. Our recent study demonstrated that andaliman ethanolic extract also exerted anti-arthritic and anti-inflammatory effects in arthritic mice in vivo. Therefore, natural anti-inflammatory and anti-arthritic compounds for alternative natural pain relievers in balsam formulation are needed. This study aimed to produce and characterize lemon pepper and black ginger extracts and their macroemulsion products, followed by formulation, characterization, and stability of spice stick balsam products containing lemon pepper and black ginger macroemulsions. The extraction yields obtained were 24% w/w for lemon pepper and 59% w/w for black ginger. GC/MS results showed that the lemon pepper extract contained limonene and geraniol compounds, and black ginger extract contained gingerol, shogaol, and tetramethoxyflavone compounds. Spice extracts were successfully made in the form of a stable emulsion. The antioxidant activity in both spice extracts and emulsions was relatively high (>50%). The five stick balsam formulas obtained had a pH of 5, 4.5–4.8 cm spread ability, and 30–50 s of adhesion. The stability of products showed no microbial contamination. Based on the organoleptic results, the stick balsam formula of black ginger and black ginger: lemon pepper (1:3) was the most preferred by the panelists. In conclusion, lemon pepper and black ginger extracts and macroemulsions could be used as natural pain relievers in stick balsam products to promote health protection.

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“…The Zanthoxylum armatum DC, known as a tooth pain tree, it was widely distributed in the subtropical Himalayas. [88][89][90][91][92] Different plants have different uses, such as fruit, leaves, and seeds as vegetables, and they have special cilanals, so they are also used as spices. The functions of the plant's plants show different biological activity, and its leaves were known for their antioxidant, insect repellent and anti-inflammatory potential, and was treated with arthritis.…”

Section: Zanthoxylum Armatummentioning

confidence: 99%

“…The Zanthoxylum armatum DC, known as a tooth pain tree, it was widely distributed in the subtropical Himalayas [88–92] . Different plants have different uses, such as fruit, leaves, and seeds as vegetables, and they have special cilanals, so they are also used as spices.…”

Section: Natural Products Reduce Uric Acidmentioning

confidence: 99%

The Inhibitory Activity of Natural Products to Xanthine Oxidase

Zhou

Huang

2023

Chemistry & Biodiversity

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The natural products have a new chemical structure and biological active diversity, so they are favored by scientific researchers. Gout is a high incidence and high-risk disease, and the current treatments are not satisfactory. Xanthine oxidase (XO) is a key enzyme responsible for the development and progression of various metabolic and oxidative stress-related diseases. Excessive activity of XO leads to elevated serum urate levels, which in turn leads to the development of hyperuricemia. This review mainly introduces the recent progress of the new research on the anti-gout activity of natural products that could provide new treatment methods for gout and information for the discovery and development of new antigout drugs.

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GC-MS Analysis of Phytocomponents and Antifungal Activities of Zanthoxylum acanthopodium DC. Collected from Manipur, India

Cited by 11 publications

References 0 publications

Chemical Composition, Antimicrobial, Nitric Oxide Inhibition and Cytotoxic Activity of Essential Oils from Zanthoxylum acanthopodium DC. Leaves and Stems from Vietnam

Chemical Composition, Antimicrobial, Nitric Oxide Inhibition and Cytotoxic Activity of Essential Oils from Zanthoxylum acanthopodium DC. Leaves and Stems from Vietnam

Characterization of Lemon Pepper and Black Ginger Extracts and Macroemulsions as Natural Pain Relievers for Spice Stick Balsam Formulation

The Inhibitory Activity of Natural Products to Xanthine Oxidase

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