GC-MS analysis, preliminary phytochemical screening, physicochemical analysis and anti-diabetic activity of ethanol extract of &lt;i&gt;Jasminum cuspidatum&lt;/i&gt; leaves

Vinay, S. D.; Karimulla, Shaik; Saravanan, Devarajan

doi:10.3329/bjp.v9i4.20602

Cited by 2 publications

(1 citation statement)

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“…The GC-MS analysis of the plant extracts are becoming a valuable tool for detection of phytochemicals which can be aimed before the process of large scale purification (Vinay et al, 2014). In the present study, the GC-MS analysis of methanol extract of E. bicolor majorly contained phenols, alkanes, terpenoids, alkaloids which might be responsible for various medicinal activities (Sellamuthu et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

GC-MS analysis, evaluation of phytochemicals, anti-oxidant, thrombolytic and anti-inflammatory activities of Exacum bicolor

Ashwini

Puttarudrappa

Ravi

et al. 2015

Bangladesh J Pharmacol

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The aim of the present study was to investigate the GC-MS analysis, phytochemical screening, anti-oxidant, thrombolytic and anti-inflammatory activities of methanol extract of leaves of Exacum bicolor. FTIR analysis confirmed the presence of alcohol, phenols, alkanes, aromatic compounds, aldehyde and ethers. GC-MS analysis revealed the presence of eight phyto-constituents. The total phenol, flavonoid and alkaloid contents were 18.0 ± 0.2 mg/GAE/g, 13.1 ± 0.4 mg QE/g and 108.0 ± 1.2 mg AE/g respectively. The DPPH assay exhibited potent anti-oxidant abilities with IC50 8.8 µg/mL. Significant thrombolytic activity was demonstrated by clot lysis method (45.1 ± 0.8%). The methanol extract showed significant membrane stabilization on human red blood cell with IC50 value of 37.4 µg/mL. There was a significant correlation (R2>0.98) with total phenolic content versus anti-oxidant and anti-inflammatory activity. The above results confirmed that E. bicolor could be a promising anti-oxidant, thrombolytic and anti-inflammatory agent.

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Section: Discussionmentioning

confidence: 99%