Gel Based Formulations in Oral Controlled Release Drug Delivery

Biswas, Gopa Roy; Mishra, Swetalina; Sufian, Abu

doi:10.52711/0974-360x.2022.00392

Cited by 3 publications

(2 citation statements)

References 64 publications

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“…They are less greasy and easier to remove from the skin. [13] On the other hand, a few disadvantages are also associated with oleogel formulation as they must have a suitable partition coefficient; otherwise, they might not be skin-permeable. Drugs that chafe or sensitize the skin should not be administered through this method.…”

Section: Review Articlementioning

confidence: 99%

Untitled

2023

IJGP

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The scientific community faces a new challenge as a result of rising concerns about the consumption of unhealthy transfats and saturated fats in the diet: Developing effective replacements for bad fats without compromising the sensory characteristics of the food product. Oleogels are said to be a cutting-edge structured fat system employed for industrial application due to their nutritional and ecological advantages among various strategies aimed to reduce/replace transfats and saturated fats in foods. The oleogel's mechanical strength, constitution, and gelator type are all elements that could influence how much and how quickly the material is being liquefied. These in turn have an impact on how lipid-soluble molecules are delivered by the oleogel. The formulation considerations of oleogels will be the main focus of this review, along with their recent food applications, particularly in the delivery of bioactives and as nutraceuticals. There will be a discussion about an understanding of oleogelators.

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Section: Review Articlementioning

confidence: 99%

Untitled

2023

IJGP

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“…In the last years, many studies have been directed towards the formulation of gels (hydrogels, nanogels, microgels) based on polymers due to their application potential in various fields, such as cosmetics [ 1 ], pharmaceuticals [ 2 ], biomedical [ 3 ], food [ 4 ], biotechnology [ 5 ], etc. Polysaccharides-based hydrogels characterized by biocompatibility, biodegradability, and non-toxicity can be applied in various biomedical interface applications.…”

Section: Introductionmentioning

confidence: 99%

Advances in the Design of Phenylboronic Acid-Based Glucose-Sensitive Hydrogels

Morariu¹

2023

Polymers

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Diabetes, characterized by an uncontrolled blood glucose level, is the main cause of blindness, heart attack, stroke, and lower limb amputation. Glucose-sensitive hydrogels able to release hypoglycemic drugs (such as insulin) as a response to the increase of the glucose level are of interest for researchers, considering the large number of diabetes patients in the world (537 million in 2021, reported by the International Diabetes Federation). Considering the current growth, it is estimated that, up to 2045, the number of people with diabetes will increase to 783 million. The present work reviews the recent developments on the hydrogels based on phenylboronic acid and its derivatives, with sensitivity to glucose, which can be suitable candidates for the design of insulin delivery systems. After a brief presentation of the dynamic covalent bonds, the design of glucose-responsive hydrogels, the mechanism by which the hypoglycemic drug release is achieved, and their self-healing capacity are presented and discussed. Finally, the conclusions and the main aspects that should be addressed in future research are shown.

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A Review on Oleogels and its Role in Pharmaceutical Field

Prusty,

Sudha

2023

RJPT

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Gel-based products called oleogels due to their required rheological, physical, and chemical stabilities in semisolid formulations not only have wide applications in the cosmetic industry, and nutraceutical industries but also they are used largely in various pharmaceutical field for formulating various topical drug delivery system and also as oil-based gels as versatile drug delivery systems for paediatric purpose. Oleogels are semisolid non-crystalline, thermo-reversible viscoelastic systems which consist of a lipophilic liquid phase (mineral or vegetable oils, isopropyl myristate) gelled with a suitable gelling agent referred as organogelators which can improve drug penetration through the stratum corneum because of their lipophilic nature. The polar phase gets trapped inside the three-dimensional networked structure present in the oleogels system, which is formed due to physical interactions among the self-assembled structures of organogelators. As these systems are resistant to the effects of moisture and do not require the addition of stabilizers or preservatives and hence they are preferred in drug delivery systems over conventional gels. The present article focuses on components, formulation aspects, and recent role of oleogels products showing its pharmaceutical applications.

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Gel Based Formulations in Oral Controlled Release Drug Delivery

Cited by 3 publications

References 64 publications

Untitled

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Advances in the Design of Phenylboronic Acid-Based Glucose-Sensitive Hydrogels

A Review on Oleogels and its Role in Pharmaceutical Field

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