Gel immersion endoscopic mucosal resection for early gastric neoplasms: a multicenter case series study

Abstract

Several cases that suggest the efficacy of gel immersion endoscopic mucosal resection (GI-EMR) for gastric neoplasms have been reported. However, no study has evaluated the treatment outcomes of GI-EMR for gastric neoplasms. This study aimed to investigate the efficacy and safety of GI-EMR for early gastric neoplasms. Nine patients (17 lesions) undergoing gastric GI-EMR were included, with a median lesion size of 10 mm (interquartile range [IQR]: 5–13 mm). All lesions were protruding or flat elevated. The median procedure time was 3 min (IQR: 2–5), achieving en bloc resection in all cases. Among 15 neoplastic lesions, the R0 resection rate was 86.7% (13/15 lesions). Adverse events included immediate bleeding requiring hemostasis in two cases, which were controlled endoscopically. No delayed bleeding or perforation occurred. In conclusion, GI-EMR might be a safe and effective treatment for small early gastric neoplasms. However, due to the small sample, further investigation is required regarding the indication of this technique.