Gel-like carbon dots: A high-performance future photocatalyst

Zhou, Yiqun; ElMetwally, Ahmed E.; Chen, Jiuyan; Shi, Wenquan; Cilingir, Emel Kirbas; Walters, Brian; Mintz, Keenan J.; Märtin, Christian; Ferreira, Braulio C.L.B.; Zhang, Wei; Hettiarachchi, Sajini D.; Serafim, Leonardo F.; Blackwelder, Patricia; Wikramanayake, Athula H.; Peng, Zhili

doi:10.1016/j.jcis.2021.04.121

Cited by 28 publications

(21 citation statements)

References 99 publications

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“…Carbon dots (CDs), a class of zero-dimensional nano materials with sizes generally less than 10 nm, have aroused attention from scientists all over the world ever since their early discovery [1,2]. Thanks to their superior properties, CDs have been successfully applied in many fields, such as in sensing [3,4], drug delivery [5,6], gene therapy [7], biological imaging [8], photocatalysis [9,10], and electrocatalysis [11,12]. Since CDs were first discovered via arc discharge and lately promoted by laser ablation [2], CDs were generally prepared by cracking bulk carbon materials in the early days (top-down synthesis).…”

Section: Introductionmentioning

confidence: 99%

Synthesis Mechanisms, Structural Models, and Photothermal Therapy Applications of Top-Down Carbon Dots from Carbon Powder, Graphite, Graphene, and Carbon Nanotubes

Shi

Han

et al. 2022

IJMS

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In this study, top-down syntheses of carbon dots (CDs) from four different carbon precursors, namely, carbon nano powders, graphite, graphene, and carbon nanotubes, were carried out. Systematic study demonstrated that the optical properties and surface functionalities of the CDs were quite similar and mainly influenced by the synthesis method, while the sizes, morphologies, chemical compositions, and core structures of the CDs were heavily influenced by the carbon precursors. On the basis of these studies, the formation processes and structural models of these four top-down CDs were proposed. The cell cytotoxicity and photothermal conversion efficiency of these CDs were also carefully evaluated, demonstrating their potential applications in photothermal therapy.

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Section: Introductionmentioning

confidence: 99%

Synthesis Mechanisms, Structural Models, and Photothermal Therapy Applications of Top-Down Carbon Dots from Carbon Powder, Graphite, Graphene, and Carbon Nanotubes

Shi

Han

et al. 2022

IJMS

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“…[4][5][6][7] Therefore, the development of highefficiency nano-photocatalysts has attracted the attention of researchers. 8 Among semiconductor photocatalysts, ZnO is a low-cost, non-toxic material, but with high recombination efficiency of photogenerated carriers. 9 However Bi-based materials -BiOX (X = Cl, Br, I), 10 Bi 2 MO 6 (M = Mo, W) 11 and Bi 2 O 2 CO 3 12 have a layered oxide with a special Aurivillius/Sillén structure, composed of alternate layers of (Bi 2 O 2 ) 2+ and X (X = Cl, Br, I, MoO 4 2− , WO 4 2− , CO 3 2− ).…”

Section: Introductionmentioning

confidence: 99%

“…4–7 Therefore, the development of high-efficiency nano-photocatalysts has attracted the attention of researchers. 8…”

Section: Introductionmentioning

confidence: 99%

Insight into the relationship between redox ability and separation efficiency via the case of α-Bi₂O₃/Bi₅NO₃O₇

Liu

Ning

et al. 2022

Inorg. Chem. Front.

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“…The quantum yield (Φ) of as-prepared DFMO CDs was calculated using the standard protocol used in our previous papers. , …”

Section: Methodsmentioning

confidence: 99%

“…The quantum yield (Φ) of asprepared DFMO CDs was calculated using the standard protocol used in our previous papers. 29,30 Cell Culture and Reagents. The MYCN-amplified neuroblastoma cell line SMS-KCNR was provided by the Children's Oncology Group.…”

Section: Synthesis Of Black Cds and Dfmo Conjugate (Bcd-dfmo)mentioning

confidence: 99%

DFMO Carbon Dots for Treatment of Neuroblastoma and Bioimaging

Paudyal

Vallejo

Cilingir

et al. 2022

ACS Appl. Bio Mater.

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Neuroblastoma (NB) is a pediatric malignancy affecting the peripheral nervous system. Despite recent advancements in treatment, many children affected with NB continue to submit to this illness, and new therapeutic strategies are desperately needed. In recent years, studies of carbon dots (CDs) as nanocarriers have mostly focused on the delivery of anticancer agents because of their biocompatibility, good aqueous dissolution, and photostability. Their fluorescence properties, surface functionalities, and surface charges differ on the basis of the type of precursors used and the synthetic approach implemented. At present, most CDs are used as nanocarriers by directly linking them either covalently or electrostatically to drug molecules. Though most modern CDs are synthesized from large carbon macromolecules and conjugated to anticancerous drugs, constructing CDs from the anticancerous drugs and precursors themselves to increase antitumoral activity requires further investigation. Herein, CDs were synthesized using difluoromethylornithine (DFMO), an irreversible ornithine decarboxylase inhibitor commonly used in high-risk neuroblastoma treatment regiments. In this study, NB cell lines, SMS-KCNR and SK-N-AS, were treated with DFMO, the newly synthesized DFMO CDs, and conventional DFMO conjugated to black carbon dots. Bioimaging was done to determine the cellular localization of a fluorescent drug over time. The mobility of DNA mixed with DFMO CDs was evaluated by gel electrophoresis. DFMO CDs were effectively synthesized from DFMO precursor and characterized using spectroscopic methods. The DFMO CDs effectively reduced cell viability with increasing dose. The effects were dramatic in the N-MYC-amplified line SMS-KCNR at 500 μM, which is comparable to high doses of conventional DFMO at a 60-fold lower concentration. In vitro bioimaging as well as DNA electrophoresis showed that synthesized DFMO CDs were able to enter the nucleus of neuroblastoma cells and neuronal cells and interact with DNA. Our new DFMO CDs exhibit a robust advantage over conventional DFMO because they induce comparable reductions in viability at a dramatically lower concentration.

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Gel-like carbon dots: A high-performance future photocatalyst

Cited by 28 publications

References 99 publications

Synthesis Mechanisms, Structural Models, and Photothermal Therapy Applications of Top-Down Carbon Dots from Carbon Powder, Graphite, Graphene, and Carbon Nanotubes

Synthesis Mechanisms, Structural Models, and Photothermal Therapy Applications of Top-Down Carbon Dots from Carbon Powder, Graphite, Graphene, and Carbon Nanotubes

Insight into the relationship between redox ability and separation efficiency via the case of α-Bi₂O₃/Bi₅NO₃O₇

DFMO Carbon Dots for Treatment of Neuroblastoma and Bioimaging

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Gel-like carbon dots: A high-performance future photocatalyst

Cited by 28 publications

References 99 publications

Synthesis Mechanisms, Structural Models, and Photothermal Therapy Applications of Top-Down Carbon Dots from Carbon Powder, Graphite, Graphene, and Carbon Nanotubes

Synthesis Mechanisms, Structural Models, and Photothermal Therapy Applications of Top-Down Carbon Dots from Carbon Powder, Graphite, Graphene, and Carbon Nanotubes

Insight into the relationship between redox ability and separation efficiency via the case of α-Bi2O3/Bi5NO3O7

DFMO Carbon Dots for Treatment of Neuroblastoma and Bioimaging

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Insight into the relationship between redox ability and separation efficiency via the case of α-Bi₂O₃/Bi₅NO₃O₇