Gelatin nanoparticles: a potential candidate for medical applications

Yasmin, Rehana; Shah, Mohsin; Khan, Saeed; Ali, Roshan

doi:10.1515/nano.0034.00109

Cited by 16 publications

(20 citation statements)

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“…Like collagen, gelatin has received much attention in the biomedical field due to its biocompatibility and high abundance. Gelatin contains a triple helical structure, similar to collagen, made of repeating amino acids: alanine, glycine, and proline [ 55 ]. Depending on the production process, gelatin can be classified as type A or type B and consist of varying molecular weights.…”

Section: Categories Of Protein Materialsmentioning

confidence: 99%

“…Gelatin nanoparticles are extensively used as successful anticancer drug carriers [ 59 ] and gene delivery vehicles [ 60 ]. Gelatin nanoparticles are able to deliver drugs across the blood brain barrier, which is a semipermeable barrier that is highly studied for drug delivery systems [ 55 ]. Gelatin nanoparticles have also safely and efficiently carried NS2 , a recombinant gene from the hepatitis C virus, without negatively impacting the function of the gene [ 61 ].…”

Section: Categories Of Protein Materialsmentioning

confidence: 99%

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Protein Polymer-Based Nanoparticles: Fabrication and Medical Applications

DeFrates

Markiewicz

Gallo

et al. 2018

IJMS

182

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Nanoparticles are particles that range in size from about 1–1000 nanometers in diameter, about one thousand times smaller than the average cell in a human body. Their small size, flexible fabrication, and high surface-area-to-volume ratio make them ideal systems for drug delivery. Nanoparticles can be made from a variety of materials including metals, polysaccharides, and proteins. Biological protein-based nanoparticles such as silk, keratin, collagen, elastin, corn zein, and soy protein-based nanoparticles are advantageous in having biodegradability, bioavailability, and relatively low cost. Many protein nanoparticles are easy to process and can be modified to achieve desired specifications such as size, morphology, and weight. Protein nanoparticles are used in a variety of settings and are replacing many materials that are not biocompatible and have a negative impact on the environment. Here we attempt to review the literature pertaining to protein-based nanoparticles with a focus on their application in drug delivery and biomedical fields. Additional detail on governing nanoparticle parameters, specific protein nanoparticle applications, and fabrication methods are also provided.

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Section: Categories Of Protein Materialsmentioning

confidence: 99%

Section: Categories Of Protein Materialsmentioning

confidence: 99%

Protein Polymer-Based Nanoparticles: Fabrication and Medical Applications

DeFrates

Markiewicz

Gallo

et al. 2018

IJMS

182

View full text Add to dashboard Cite

show abstract

“…Amphotericin B (AmB) is a polyene antibiotic which is used for the treatment of visceral leishmaniasis. AmB loaded functionalized gelatin nanoparticles reduce the cytotoxicity and enhance the uptake by macrophages [ 82 ]. In vitro and in vivo 1,2-diacyl-sn-glycero-3-phospho-1-serine coated gelatin nanoparticles loaded AmB shows high accumulation of AmB in liver and spleen which enhance antileishmanial activity [ 83 ].…”

Section: Biomedical Application Of Protein Nanoparticlesmentioning

confidence: 99%

Protein Based Nanostructures for Drug Delivery

Verma

Gulati

Kaul

et al. 2018

Journal of Pharmaceutics

139

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The key role of protein based nanostructures has recently revolutionized the nanomedicine era. Protein nanoparticles have turned out to be the major grounds for the transformation of different properties of many conventional materials by virtue of their size and greater surface area which instigates them to be more reactive to some other molecules. Protein nanoparticles have better biocompatibilities and biodegradability and also have the possibilities for surface modifications. These nanostructures can be synthesized by using protein like albumin, gelatin, whey protein, gliadin, legumin, elastin, zein, soy protein, and milk protein. The techniques for their fabrication include emulsification, desolvation, complex coacervation, and electrospray. The characterization parameters of protein nanoparticles comprise particle size, particle morphology, surface charge, drug loading, determination of drug entrapment, and particle structure and in vitro drug release. A plethora of protein nanoparticles applications via different routes of administration are explored and reported by eminent researchers which are highlighted in the present review along with the patents granted for protein nanoparticles as drug delivery carriers.

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“…Moreover, the ease of modification and crosslinking make gelatin a favorable candidate of drug delivery with improved stability and physicochemical characteristics. 85 …”

Section: Nanoparticles As Atherosclerosis Prevention and Treatment Dementioning

confidence: 99%

Combating atherosclerosis with targeted nanomedicines: recent advances and future prospective

Nakhlband¹,

Eskandani²,

Omidi³

et al. 2018

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Introduction: Cardiovascular diseases (CVDs) is recognized as the leading cause of mortality worldwide. The increasing prevalence of such disease demands novel therapeutic and diagnostic approaches to overcome associated clinical/social issues. Recent advances in nanotechnology and biological sciences have provided intriguing insights to employ targeted Nanomachines to the desired location as imaging, diagnosis, and therapeutic modalities. Nanomedicines as novel tools for enhanced drug delivery, imaging, and diagnosis strategies have shown great promise to combat cardiovascular diseases. Methods: In the current study, we intend to review the most recent studies on the nano-based strategies for improved management of CVDs. Results: A cascade of events results in the formation of atheromatous plaque and arterial stenosis. Furthermore, recent studies have shown that nanomedicines have displayed unique functionalities and provided de novo applications in the diagnosis and treatment of atherosclerosis. Conclusion: Despite some limitations, nanomedicines hold considerable potential in the prevention, diagnosis, and treatment of various ailments including atherosclerosis. Fewer side effects, amenable physicochemical properties and multi-potential application of such nano-systems are recognized through various investigations. Therefore, it is strongly believed that with targeted drug delivery to atherosclerotic lesions and plaque, management of onset and progression of disease would be more efficient than classical treatment modalities.

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Gelatin nanoparticles: a potential candidate for medical applications

Cited by 16 publications

References 0 publications

Protein Polymer-Based Nanoparticles: Fabrication and Medical Applications

Protein Polymer-Based Nanoparticles: Fabrication and Medical Applications

Protein Based Nanostructures for Drug Delivery

Combating atherosclerosis with targeted nanomedicines: recent advances and future prospective

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