Gelatinolytic activity in gingival crevicular fluid and saliva of growing patients with Marfan syndrome: a case-control study

Laganà, Giuseppina; Fasciglione, Giovanni Francesco; Biondi, Andrea; Coletta, Massimo; Ruvolo, Giovanni; Cozza, Paola

doi:10.1186/s12903-019-0854-x

Cited by 6 publications

(4 citation statements)

References 30 publications

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“…Besides, fibrillin-1 has been suggested to be essential for normal tissue structure and gene expression of the periodontal ligament [ 30 ]. What is more, a recent study revealed higher MMP-13 activity in the crevicular fluid of MFS patients compared to healthy individuals, which could lead to significant degradation of the periodontal matrix and an altered response in case of periodontal inflammation [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Periodontitis among Patients Diagnosed with Marfan Syndrome: A Cross-Sectional Study Comparing Samples of Healthy Patients

Galletti

Toledano‐Serrabona

Camps‐Font

et al. 2022

BioMed Research International

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Periodontitis is an inflammatory condition caused by a bacterial plaque and characterized by progressive destruction of the tooth-supporting apparatus. Patients with Marfan syndrome (MFS) exhibit a connective tissue disorder, which can also affect oral soft and hard tissue. Thus, the aims of this cross-sectional study were to assess the association between periodontitis and MFS and secondly, to compare periodontal parameters and prevalence of disease with a control group (CG) without MFS. 152 patients ( MFS = 76 , CG = 76 ) were recruited to evaluate the following periodontal parameters: probing depth, gingival margin, clinical attachment level, plaque index, and bleeding on probing. The 2017 World Workshop guideline was followed for the diagnosis of the periodontal status. A multivariate analysis was performed using a multinomial logistic regression adjusted for age, gender, and smoking. The level of significance required was p < 0.05 . Patients with MFS did not show a higher prevalence of periodontitis compared to the CG. However, patients with MFS did have higher values in probing depth, gingival recession, clinical attachment level, and plaque index compared to the CG patients ( p < 0.05 ). In conclusion, although similar prevalence of periodontitis was found among the studied groups, MFS patients showed worse periodontal parameters.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Periodontitis among Patients Diagnosed with Marfan Syndrome: A Cross-Sectional Study Comparing Samples of Healthy Patients

Galletti

Toledano‐Serrabona

Camps‐Font

et al. 2022

BioMed Research International

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“…Gelatin substrate zymography was used for the evaluation of saliva MMP gelatinolytic activities in the salivary samples [ 16 ]. Briefly, 1.8 μg of saliva proteome were loaded in each lane.…”

Section: Methodsmentioning

confidence: 99%

Saliva Analysis of pH and Antioxidant Capacity in Adult Obstructive Sleep Apnea Patients

Venza

Alloisio

Gioia

et al. 2022

IJERPH

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Background: Obstructive sleep apnea syndrome (OSAS) may be associated with and activates the stress response system, and variation in the physiological antioxidant capacity of body fluids. Our aim was to evaluate the variation of pH and antioxidant capacity on the saliva of obstructive sleep apnea subjects (OG) compared to a control group (CG). Method: Fifty subjects with moderate/severe OSAS were recruited in Tor Vergata Hospital and compared with 20 healthy subjects CG. The buffer and the antioxidant capacity of the samples were quantified measuring the pH and the percentage of total salivary antioxidant capacity (%TAC), which refers to the reduced glutathione salivary concentration (GSH). Moreover, the protein concentration and the gelatinolytic activity of metalloproteinases were quantified. Results: The data showed that the pH value is slightly more alkaline in OSAS subjects; however, it is not directly related to the severity of OSAS. The %TAC was found to be significantly reduced by 86.2% in the OG. Proteins of saliva from the OG were found 1.5 times more concentrated than in the healthy sample. The gelatinolytic activity of metalloproteinases of healthy and OSA did not show statistically significant changes. Conclusions: The salivary samples from OSAS compared to CG show an alteration of the oxidative state, the pH buffering power, and protein concentrations, inducing conditions that can easily evolve chronic gingivitis. Further investigations are necessary to evaluate the feasibility of using salivary fluid for the early diagnosis of oral or systemic problems in OSAS subjects.

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“…Table 1 [8,9,[17][18][19][20][21][22][23][24] lists the most important aspects of the studies that were considered. Peer-reviewed journals were used to publish all of the investigations.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Peer-reviewed journals were used to publish all of the investigations. A total of 3 of the 10 studies were carried out in Germany [8,17,20] and Italy [18,19,21], 2 in Japan [22,23], and 2 in Belgium [9,24]. The measurement of gingival and periodontal clinical parameters was the most employed method in the studies.…”

Section: Study Characteristicsmentioning

confidence: 99%

Oral Health Status in Marfan Syndrome: A Systematic Review and Meta-Analysis of 353 Cases

Alam

Alfawzan

Shrivastava

et al. 2022

IJERPH

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This meta-analysis aimed to compare Marfan syndrome (MFS) patients with non-MFS populations based on orofacial health status to combine publicly available scientific information while also improving the validity of primary study findings. A comprehensive search was performed in the following databases: PubMed, Google Scholar, Scopus, Medline, and Web of Science, for articles published between 1 January 2000 and 17 February 2022. PRISMA guidelines were followed to carry out this systematic review. We used the PECO system to classify people with MFS based on whether or not they had distinctive oral health characteristics compared to the non-MFS population. The following are some examples of how PECO is used: P denotes someone who has MFS; E stands for a medical or genetic assessment of MFS; C stands for people who do not have MFS; and O stands for the orofacial characteristics of MFS. Using the Newcastle–Ottawa Quality Assessment Scale, independent reviewers assessed the articles’ methodological quality and extracted data. Four case-control studies were analyzed for meta-analysis. Due to the wide range of variability, we were only able to include data from at least three previous studies. There was a statistically significant difference in bleeding on probing and pocket depth between MFS and non-MFS subjects. MFS patients are more prone to periodontal tissue inflammation due to the activity of FBN1 and MMPs. Early orthodontic treatment is beneficial for the correction of a narrow upper jaw and a high palate, as well as a skeletal class II with retrognathism of the lower jaw and crowding of teeth.

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Gelatinolytic activity in gingival crevicular fluid and saliva of growing patients with Marfan syndrome: a case-control study

Cited by 6 publications

References 30 publications

Prevalence of Periodontitis among Patients Diagnosed with Marfan Syndrome: A Cross-Sectional Study Comparing Samples of Healthy Patients

Prevalence of Periodontitis among Patients Diagnosed with Marfan Syndrome: A Cross-Sectional Study Comparing Samples of Healthy Patients

Saliva Analysis of pH and Antioxidant Capacity in Adult Obstructive Sleep Apnea Patients

Oral Health Status in Marfan Syndrome: A Systematic Review and Meta-Analysis of 353 Cases

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