Gelation time and degradation rate of chitosan-based injectable hydrogel

Ganji, Fariba; Abdekhodaie, Mohammad J.; Ramazani, Ahmad

doi:10.1007/s10971-006-9007-1

Cited by 146 publications

(101 citation statements)

References 30 publications

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“…89,93 The kinetics of degradation of chitosan by cell-secreted lysozyme can be controlled through hydrogel properties such as crystallinity and through chitosan's degree of acetylation. 90,92 Chitosan has been modified to increase biochemical similarity to cartilage 85,88,94,112 and to prepare injectable scaffolds. [84][85][86]91,95 Chondrocytes encapsulated in injectable chitosan hydrogels repaired non-weightbearing defects in sheep, with good integration with the surrounding tissue.…”

Section: Type Of Polymermentioning

confidence: 99%

Hydrogels for the Repair of Articular Cartilage Defects

Spiller

Maher

Lowman

2011

Tissue Engineering Part B: Reviews

404

312

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Section: Type Of Polymermentioning

confidence: 99%

Hydrogels for the Repair of Articular Cartilage Defects

Spiller

Maher

Lowman

2011

Tissue Engineering Part B: Reviews

404

312

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“…C/GP solution composed of 1.4-2.2% (w/v) chitosan and 6-12% (w/v) β-GP was gelled at 37°C with different gelation times. The increase of chitosan and β-GP concentrations could both reduce gelation time which might be related to the increase of intermolecular interactions and entanglements (31,32). The pH values of different formulations were around 6.9 in the tumor pH range.…”

Section: Results and Discussion Preparation Of The C/gp Solutionmentioning

confidence: 98%

Efficacy, Pharmacokinetics, and Biodistribution of Thermosensitive Chitosan/β-Glycerophosphate Hydrogel Loaded with Docetaxel

Ren

Dai

et al. 2014

AAPS PharmSciTech

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Abstract. Docetaxel (DTX) is a widely used anticancer drug for various solid tumors. However, its poor solubility in water and lack of specification are two limitations for clinical use. The aim of the study was to develop a thermosensitive chitosan/β-glycerophosphate (C/GP) hydrogel loaded with DTX for intratumoral delivery. The in vitro release profiles, in vivo antitumor efficacy, pharmacokinetics, and biodistribution of DTX-loaded C/GP hydrogel (DTX-C/GP) were evaluated. The results of in vitro release study demonstrated that DTX-C/GP had the property of controlled delivery for a reasonable time span of 3 weeks and the release period was substantially affected by initial DTX strength. The antitumor efficacy of DTX-C/GP was observed at 20 mg/kg in H22 tumor-bearing mice. It was found that the tumor volume was definitely minimized by intratumoral injection of DTX-C/GP. Compared with saline group, the tumor inhibition rate of blank gel, intravenous DTX solution, intratumoral DTX solution, and DTX-C/GP was 2.3%, 29.8%, 41.9%, and 58.1%, respectively. Further, the in vivo pharmacokinetic characteristics of DTX-C/GP correlated well with the in vitro release. DTX-C/GP significantly prolonged the DTX retention and maintained a high DTX concentration in tumor. The amount of DTX distributed to the normal tissues was minimized so that the toxicity was effectively reduced. In conclusion, DTX-C/GP demonstrated controlled release and significant efficacy and exhibited potential for further clinical development.

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“…On the other hand, for the preparations of physically crosslinked hydrogels, several techniques have been implied such as hydrogen bonding, [37,38] crystallization, [39] protein interaction, [40] ionic interaction, [41][42][43] and by hydrophobic interaction. [44,45] Stimuli responsive hydrogels are nowadays gaining a wide interest in the field of drug delivery system and have numerous potential applications.…”

Section: Introductionmentioning

confidence: 99%

Insight into hydrogels

Khan

Ullah

et al. 2016

Designed Monomers and Polymers

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The development and introduction of injectable biomaterials and the identification of methods through which materials may form in situ are currently the topics of interest in materials science, specifically in the field of biomaterials. Over the last few decades, hydrogels which refers to the swellable polymeric matrices have gained wide attention due to their excellent characteristics such as swelling in different media, pH and temperature sensitivity, and sensitivity to other stimuli. Nowadays, injectable hydrogels have widely been studied due to their excellent insitu gelation at body temperature. These injectable insitu gels serve as depot system which ensures the local and systemic drug and gene delivery. These insitu gels also protect the proteins and peptide drugs invivo from environmental effect. The current review is made to report latest extensive literature regarding hydrogels, their classification, synthesis methods, structure of hydrogel network, methods of crosslinking, environment-sensitive hydrogel system, drug loading, and release, hydrogels as biosensors and applications of hydrogels.

show abstract

Gelation time and degradation rate of chitosan-based injectable hydrogel

Cited by 146 publications

References 30 publications

Hydrogels for the Repair of Articular Cartilage Defects

Hydrogels for the Repair of Articular Cartilage Defects

Efficacy, Pharmacokinetics, and Biodistribution of Thermosensitive Chitosan/β-Glycerophosphate Hydrogel Loaded with Docetaxel

Insight into hydrogels

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