Gender, age‐related, and regional differences of the magnetization transfer ratio of the cortical and subcortical brain gray matter

Mascalchi, Mario; Toschi, Nicola; Ginestroni, Andrea; Giannelli, Marco; Nicolai, Emanuele; Aiello, Marco; Soricelli, Andrea; Diciotti, Stefano

doi:10.1002/jmri.24355

Cited by 11 publications

(7 citation statements)

References 34 publications

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“…This is attributed to the higher protein content of myelin sheaths variably covering the neuronal axons of nerve fibers [12, 16–18]. While the higher MT effect explains the predominant applications of MT imaging to evaluate normal development and diseases of the WM [11], several studies have employed MT contrast for studying also normal [17, 19, 20] and disease states [11] of cortical and subcortical GM.…”

Section: Introductionmentioning

confidence: 99%

Handedness Side and Magnetization Transfer Ratio in the Primary Sensorimotor Cortex Central Sulcus

Mascalchi

Ciulli

Bianchi

et al. 2019

BioMed Research International

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Left-handers show lower asymmetry in manual ability when compared to right-handers. Unlike right-handers, left-handers do not show larger deactivation of the ipsilateral primary sensorimotor (SM1) cortex on functional magnetic resonance imaging when moving their dominant than their nondominant hand. However, it should be noted that morphometric MRI studies have reported no differences between right-handers and left-handers in volume, thickness, or surface area of the SM1 cortex. In this regard, magnetization transfer (MT) imaging is a technique with the potential to provide information on microstructural organization and macromolecular content of tissue. In particular, MT ratio index of the brain gray matter is assumed to reflect the variable content of afferent or efferent myelinated fibers, with higher MT ratio values being associated with increased fibers number or degree of myelination. The aim of this study was hence to assess, for the first time, through quantitative MT ratio measurements, potential differences in microstructural organization/characteristics of SM1 cortex between left- and right-handers, which could underlay handedness side. Nine left-handed and 9 right-handed healthy subjects, as determined by the Edinburgh handedness inventory, were examined with T1-weighted and MT-weighted imaging on a 3 T scanner. The hands of subjects were kept still during all acquisitions. Using FreeSurfer suite and the automatic anatomical labeling parcellations defined by the Destrieux atlas, we measured MT ratio, as well as cortical thickness, in three regions of interests corresponding to the precentral gyrus, the central sulcus, and the postcentral gyrus in the bilateral SM1 cortex. No significant difference between left- and right-handers was revealed in the thickness of the three partitions of the SM1 cortex. However, left-handers showed a significantly (p = 0.007) lower MT ratio (31.92% ± 0.96%) in the right SM1 central sulcus (i.e., the hand representation area for left-handers) as compared to right-handers (33.28% ± 0.94%). The results of this preliminary study indicate that quantitative MT imaging, unlike conventional morphometric MRI measurements, can be a useful tool to reveal, in SM1 cortex, potential microstructural correlates of handedness side.

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Section: Introductionmentioning

confidence: 99%

Handedness Side and Magnetization Transfer Ratio in the Primary Sensorimotor Cortex Central Sulcus

Mascalchi

Ciulli

Bianchi

et al. 2019

BioMed Research International

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“…Third, although MTR may be considered sensitive to alteration in the microstructual environment, its ability to reveal specific forms of underlying pathology (e.g., inflammation, edema, Wallerian degeneration, demyelination) requires further investigation, particularly in TBI where multiple forms of pathology may co-occur. MTI-based measures may also be quite sensitive to age-related changes, particularly in cortical and subcortical GM structures (Mascalchi et al 2014; Newbould et al 2014; Callaghan et al 2014). Finally not all studies have found a clear association between MTI-derived metrics and outcome (Bagley et al 2000; Petrie et al 2014), and additional research in this area is warranted.…”

Section: Magnetization Transfer Imagingmentioning

confidence: 99%

Advanced neuroimaging applied to veterans and service personnel with traumatic brain injury: state of the art and potential benefits

Wilde

Bouix

Tate

et al. 2015

Brain Imaging and Behavior

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Traumatic brain injury (TBI) remains one of the most prevalent forms of morbidity among Veterans and Service Members, particularly for those engaged in the conflicts in Iraq and Afghanistan. Neuroimaging has been considered a potentially useful diagnostic and prognostic tool across the spectrum of TBI generally, but may have particular importance in military populations where the diagnosis of mild TBI is particularly challenging, given the frequent lack of documentation on the nature of the injuries and mixed etiologies, and highly comorbid with other disorders such as post-traumatic stress disorder, depression, and substance misuse. Imaging has also been employed in attempts to understand better the potential late effects of trauma and to evaluate the effects of promising therapeutic interventions. This review surveys the use of structural and functional neuroimaging techniques utilized in military studies published to date, including the utilization of quantitative fluid attenuated inversion recovery (FLAIR), susceptibility weighted imaging (SWI), volumetric analysis, diffusion tensor imaging (DTI), magnetization transfer imaging (MTI), positron emission tomography (PET), magnetoencephalography (MEG), task-based and resting state functional MRI (fMRI), arterial spin labeling (ASL), and magnetic resonance spectroscopy (MRS). The importance of quality assurance testing in current and future research is also highlighted. Current challenges and limitations of each technique are outlined, and future directions are discussed.

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“…Entretanto, estudos que abordam a retrogênese indicam uma maior carga de fatores intrínsecos na expressão das perdas durante o envelhecimento, especialmente relacionada a aspectos neurológicos (BORGES et al, 2010;R ATHI et al, 2014;MASCALCHI et al, 2014). A morte de neurônios, diminuição do comprimento e número de dendritos, desmielinização das grandes fibras, redução da quantidade de neurotransmissores e acúmulo de substâncias anômalas no meio extracelular são algumas alterações neurológicas comuns ao processo da retrogênese, e tem como consequência um decréscimo nas respostas motoras (FJELL et al, 2013;LOCKHART;DE CARLI, 2014).…”

Section: Introductionunclassified

Desenvolvimento Motor De Idosos: Estudo Comparativo De Sexo E Faixa Etária

Andreis¹,

Guidarini²,

Garcia³

et al. 2018

Cad. Bras. Ter. Ocup.

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Resumo: Introdução: No desenvolvimento motor, o envelhecimento é representado pela retrogênese, processo que se refere às perdas gradativas nos componentes motores. Fatores intrínsecos e extrínsecos podem influenciar este processo. Objetivo: Avaliar e comparar o desenvolvimento motor de idosos considerando o sexo e a faixa etária. Método: Foram avaliados 218 idosos hígidos com idade entre 60 e 79 anos estratificados por sexo e faixa etária, constituindo quatro grupos: G1(n=64)-sexo feminino, 60-69 anos; G2 (n=45)-sexo feminino, 70-79 anos; G3 (n=66)-sexo masculino, 60-69 anos; G4 (n=43)-sexo masculino, 70-79 anos. O instrumento utilizado para coleta dos dados foi a Escala Motora para Terceira Idade (EMTI). Na análise estatística, empregou-se teste H de Kruskal Wallis e post hoc Dunn. Resultados: Observou-se que a maioria dos idosos apresentou desenvolvimento motor dentro da normalidade. O grupo do sexo feminino, 70-79 anos, foi o que apresentou valores médios inferiores (͞ x=87,7; DP=12,4), sendo diferente estatisticamente quando comparado os grupos. Nas áreas motoras, diferenças estatísticas significantes foram encontradas entre os grupos na Coordenação Global (p=0,001), Equilíbrio (p=0,001) e Esquema Corporal (p=0,012); nesta análise, as mulheres alcançaram pontuações inferiores aos homens na maioria das áreas avaliadas. Conclusão: As mulheres idosas com idade mais avançada apresentaram maior comprometimento no desenvolvimento motor quando comparadas aos homens idosos e mulheres idosas mais jovens.

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Gender, age‐related, and regional differences of the magnetization transfer ratio of the cortical and subcortical brain gray matter

Abstract: MTR of the cortical and subcortical brain GM structures decreases quadratically after midlife and shows significant regional differences.

Cited by 11 publications

References 34 publications

Handedness Side and Magnetization Transfer Ratio in the Primary Sensorimotor Cortex Central Sulcus

Handedness Side and Magnetization Transfer Ratio in the Primary Sensorimotor Cortex Central Sulcus

Advanced neuroimaging applied to veterans and service personnel with traumatic brain injury: state of the art and potential benefits

Desenvolvimento Motor De Idosos: Estudo Comparativo De Sexo E Faixa Etária

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