“…In malformations of the CNS, significance is given to the age of the mother, as the frequency is in the form of a U-shaped curve, with the highest frequencies at a very young age - under 18 yr and over 38 yr ( 1 ). In addition to the age of the mother, interfamilial marriage, the season of conception, variations in amniotic fluid and the sex of the fetus are etiopathogenetic factors associated with malformations from the group of NTDs ( 2 , 3 ).…”