2016
DOI: 10.1042/bsr20150281
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Gender difference in plasma fatty-acid-binding protein 4 levels in patients with chronic obstructive pulmonary disease

Abstract: Plasma FABP4 levels were higher in females with COPD compared with both males with COPD and healthy females. FABP4 levels correlated inversely with lung function, and positively with adiponectin and TNFα in COPD.

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Cited by 24 publications
(37 citation statements)
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“…Zhang et al . did not prove a positive link with BMI in individuals with chronic obstructive pulmonary disease [25]. With respect to the relationship with other adipokines, no association was demonstrated in the present study between adiponectin and leptin, other than a significant inverse relationship with RBP-4.…”
Section: Discussioncontrasting
confidence: 86%
See 1 more Smart Citation
“…Zhang et al . did not prove a positive link with BMI in individuals with chronic obstructive pulmonary disease [25]. With respect to the relationship with other adipokines, no association was demonstrated in the present study between adiponectin and leptin, other than a significant inverse relationship with RBP-4.…”
Section: Discussioncontrasting
confidence: 86%
“…also found higher concentrations of the heart isoform of FABP in men as well as an increase with age, but in healthy volunteers [24]. Conversely, FABP4 seems to be more closely related to women and age, but it has not been investigated in relation to psoriasis [18, 25]. FABP4 was not associated with sex in our study group.…”
Section: Discussionmentioning
confidence: 44%
“…These differences may be due to some methodological nuances or other modifying factors within the studied groups. There were no statistical differences in terms of sex in both of our studies, although a significantly elevated level of adipocyte-type FABP was reported in females suffering from chronic obstructive pulmonary disease (COPD) (Zhang, 2016) and type 2 diabetes (Li, 2016).…”
Section: Discussioncontrasting
confidence: 59%
“…Furthermore, statistical correlations of FABP4 with HDL‐cholesterol and LDL‐cholesterol, TAG, BMI, or CRP have been shown in other diseases (Kralisch, ; Li, ; Xu, ). Contrarily, Zhang () did not prove a positive relation with BMI in patients with COPD. Niu, found elevated FABP4 levels in obese individuals newly diagnosed with type 2 diabetes compared to healthy controls and nonobese diabetics or nondiabetic obese patients.…”
Section: Discussionmentioning
confidence: 89%
“…Finally, 13 articles were included for this meta-analysis, containing 1131 COPD patients and 689 controls in total. The subjects of nine studies were stable COPD patients [15][16][17][18][19][20][21][22][23], three studies involved stable COPD patients and AECOPD patients [24][25][26], and one study involved mixed COPD patients [27]. In 12 studies [15][16][17][18][19][20][21][22][23][25][26][27], the control participants were matched for all the main confounders (BMI, age, gender) with the OSA patients.…”
Section: Study Inclusion and Characteristicsmentioning
confidence: 99%